eMEDICAL BOOKS

Bone Toxicology (Molecular and Integrative Toxicology) 1st ed. 2017 Edition

October 10, 2017

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The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

About the Author

Susan Y. Smith is a consultant who specializes in nonclinical muscoloskeletal research. She provides guidance for the conduct of pharmacology, efficacy or safety studies, or help with data interpretation to unravel the mysteries of skeletal evaluations. She received a Master of Science in Pharmacology at McGill University and later joined Charles River Laboratories for almost 18 years and where she became Senior Scientific Director of Musculoskeletal Research. She has over 30 years of experience in preclinical safety assessments and toxicology and over 20 years of expertise in bone research.

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Diagnostic Clusters in Shoulder Conditions 1st ed. 2017 Edition

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This book serves as a definitive guide to diagnosing shoulder conditions for trainees, general practitioners, physiotherapists, orthopaedic surgeons and radiologists with an interest in shoulder pathology. It comes at a time when the knowledge regarding shoulder conditions has vastly improved, with the shoulder sub-speciality growing at a rapid pace in terms of practitioner numbers, procedures and evidence base.

It is unclear, in most circumstances, which single clinical test or indeed radiological investigation is the best for diagnosing a particular condition. In fact, the diagnosis of a particular shoulder condition rests on the four sub-components of clinical history, conventional examination, special tests and radiological investigations. It is often the case that all these sub-components are to be used in conjunction with each other as “clusters” rather than in isolation. This forms the basis of the cluster approach, which is the key concept for the title and content of this book. This book presents a practical guide for diagnosis, written by a select group of surgeons and physiotherapists with a special interest in shoulder pathologies, who have painstakingly extracted these relevant clusters for each shoulder conditions from clinical experience and published work.

About the Author

Puneet Monga is a UK-based Consultant Orthopaedic Shoulder Surgeon at the Wrightington Hospital, and a Honorary Senior Lecturer at the University of Salford and Edge Hill University.

Lennard Funk is a UK-based Consultant Orthopaedic Shoulder Surgeon at the Wrightington hospital, and a Honorary Professor at the University of Salford.

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Career Skills for Surgeons 1st ed. 2017 Edition

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This book presents various skills to help surgeons improve their day-to-day performance and development including professionalism, communication, situation awareness, decision making, leadership, and technical dexterity. It also offers advice on how to organise a surgical theatre list, improve theatre efficiency, prepare for surgical interviews and participate in surgical research and audit. Furthermore, it emphasises the need to strive for safety in surgery and to learn from things going wrong. The complex world of emotions that surgeons may encounter is also discussed. The guidance presented here may be of value to any aspiring surgeon, whatever their surgical specialty, and wherever they choose to practise.

The skills highlighted in this book reflect the author’s initial experiences as a surgical trainee, the teachings of his senior trainers, as well as his subsequent involvement in supervising multiple junior surgeons as a Consultant in Trauma and Orthopaedics. Much of the material presented is supported by an extensive literature review. This book complements the previously published book “Career Skills for Doctors” by the same author.

About the Author

Bambos (short for Charalambos) studied Medicine at the University of Manchester, UK and completed his postgraduate surgical and orthopaedic training in the North West of England. He is currently a consultant in trauma and orthopaedics at Blackpool Teaching Hospitals NHS Foundation Trust, UK, where he leads and manages his team, providing a busy clinical service.

Bambos is an Honorary Professor at the University of Central Lancashire School of Medicine and has a keen interest in medical education, acting as clinical and educational supervisor, as well as mentor to multiple junior surgeons at various levels of training. He is an enthusiast in clinical research and audit and has published extensively in these areas.

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General Surgery

Obstetrics Essentials: A Question-Based Review 1st ed. 2017 Edition

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This book is a compact question-based review of the most critical topics an obstetrician will come across in practice. Each chapter includes 10-30 multiple-choice questions designed to test the readers understanding surrounding one obstetric topic. Based on all 45 obstetric based practice bulletins by ACOG, this text is designed to keep practitioners up-to-date with the latest evidence based medicine. Sample topics include: anemia in pregnancy, screening for fetal chromosomal abnormalities, and vaginal birth after previous cesarean delivery. This is an ideal tool for attendings and clerkship directors who frequently test residents and medical students during rounds and in the classroom. This review also proves useful for practicing physicians and physicians-in-training who want to self-evaluate their comprehension and study for board examinations.

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Obstetrics & Gynecology

Cardiac Arrhythmias, Pacing and Sudden Death (Cardiovascular Medicine) 1st ed. 2017 Edition

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This book provides up-to-date, user-friendly and comprehensive guidance on the evaluation, diagnosis, and medical and surgical treatment of cardiac arrhythmias. This ensures that that this title aids every trainee and practicising cardiologist, cardiac electrophysiologist, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients.

Cardiovascular Medicine: Cardiac Arrhythmias, Pacing and Sudden Death covers every aspect of cardiac arrhythmias, from cardiac signs and symptoms through imaging and the genetic basis for disease to surgery, interventions, treatment and preventive cardiology. This coverage is presented with consistent chapter organization, clear design, and engaging text that includes user-friendly features such as tables, lists and treatment boxes.

About the Author

Peter R. Kowey, MD, is Professor of Medicine and Clinical Pharmacology at Jefferson Medical College. He is also Chief of the Division of Cardiovascular Diseases at the Lankenau Hospital Main Line Health System and President of the Main Line Health Heart Center and is the William Wikoff Smith Chair in Cardiovascular Research.

After Dr Kowey’s training at Penn State University and Harvard University School of Public Health he joined the faculty at the Medical College of Pennsylvania as Director of the CCU and Arrhythmia Program, where he rose to the rank of full Professor.

Dr Kowey is a Fellow of several professional organizations including the Clinical Council of the American Heart Association, the American College of Cardiology, the American College of Physicians, the College of Physicians of Philadelphia, the American College of Chest Physicians, and the American College of Clinical Pharmacology. He spent 9 years as a member of the Cardiorenal Drug Advisory Committee, 4 years on the Cardiovascular Devices Committee of the Food and Drug Administration, and was on the Expert Advisory Panel of the US Pharmacopeial convention. Dr Kowey’s principal area of interest has been cardiac rhythm disturbances.

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Phosphodiesterases: CNS Functions and Diseases (Advances in Neurobiology) 1st ed. 2017 Edition

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PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer’s Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

About the Author

Dr. Han-Ting Zhang received his M.D. from Southern Medical University (formerly the First Military Medical University) in Guangzhou and M.S. and Ph.D. of Pharmacology from Beijing Institute of Pharmacology & Toxicology, the Military Academy of Medical Sciences, China in 1995. He worked as a postdoctoral fellow at Louisiana State University Health Sciences Center in 1998 and then at University of Tennessee Health Science Center in 2000. In 2005 Dr. Zhang joined the Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology as a faculty at West Virginia University School of Medicine, Morgantown, WV, USA. He has been a tenured Associate Professor there since 2012. Dr. Zhang is also a “Taishan Scholars” Overseas Distinguished Expert and Professor of Pharmacology at Taishan Medical University (adjunct), China.

Dr. Zhang’s major research interests focus on intracellular signaling in the mediation of neurodegenerative and psychiatric disorders. More specifically, he is interested in exploring the roles of phosphodiesterase (PDE)-mediated cyclic nucleotide (cAMP, cGMP) signaling in depression, anxiety, alcohol dependence, drug abuse, and cognition deficits associated with neurodegenerative disorders such as Alzheimer disease. Development of novel drugs for treating these disorders is also one of his research foci.

Dr. Zhang has published nearly 80 research papers and review articles and 18 book chapters, most of which focusing on PDEs, in particular the PDE4 enzyme family. He has been awarded the NARSAD Young Investigator Award twice (2006 and 2008). Dr. Zhang has been served as the Guest Chief Editor of Current Pharmaceutical Design and currently serves as the Deputy Chief Editor/Associate Editor for Metabolic Brain Disease, Frontiers in Pharmacology, Frontiers in Aging Neuroscience, Translational Neuroscience Review, Austin Psychiatry, and Editorial Board member for Scientific Reports and several other international journals.

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Science of Ashwagandha: Preventive and Therapeutic Potentials 1st ed. 2017 Edition

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Rapidly increasing aging population and environmental stressors are the two main global concerns of increasing incidence of a variety of pathologies in the modern society. The complex etiologies and pathologies cause major challenges to disease treatment. On the other hand, several herbs are known for their health-caring and disease-curing activities. Ashwagandha, a popular herb in Indian traditional home medicine, Ayurveda, has gathered increasing recognition in recent years when the chemically synthesized drugs for single target therapies showed limited success and adverse toxic effects. Ashwagandha is known as a powerful adaptogen and trusted to enhance function of the brain, reproductive system, cell-mediated immunity and increase the body’s defense against disease, and possess anti-inflammatory, anticancer and anti-arthritic activities. In this book, for the first time, we provide a complete portrait on scientific understanding of the effects of Ashwagandha and its active principles for a variety of preventive and therapeutic activities.

About the Author

Dr. Sunil Kaul was born and brought up in Kalimpong (Darjeeling). He obtained his MPhil and PhD degrees from the University of Delhi, India. After his initial post-doctoral training, he was appointed as a researcher at the National Institute of Advanced Industrial Science & Technology (AIST) in Japan, and has been working there for last 28 years. He is now a Chief Senior Research Scientist. His major research interest is to understand the molecular mechanism of stress, aging and cancer. He has been merging the traditional knowledge with modern technologies like gene silencing and imaging to understand the mechanism of action of Ayurvedic herb, Ashwagandha and others. He is a coordinator of the DBT (India)-AIST (Japan) International Laboratory for Advanced Biomedicine at AIST, Japan. With more than 200 research publications in International peer revised journals and several invited talks Internationally, he has been in Editorial board of several scientific journals. He is a Fellow of Geriatrics Society of India (FGSI), Overseas Fellow of Biotech Research Society of India (FBRSI), Fellow of Indian Academy of Neuroscience (FIAN), and Foreign Fellow of National Academy of Sciences, India (FNASc).

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Dermatological Atlas of Indigenous People 1st ed. 2017 Edition

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Skin diseases are highly prevalent among indigenous people, leading to low mortality but greatly impacting their quality of life. Such diseases can be observed in indigenous people; both those living in isolated communities and those who have since been urbanized to some degree share a common characteristic of presenting different clinical patterns than non-indigenous individuals. These specificities necessitate a special approach when diagnosing dermatologic diseases in indigenous people. However, these considerations are rarely discussed in standard dermatology books.

This Atlas addresses that gap by providing specific materials for professionals involved in the health of indigenous people, especially with those who live either alone or in remote areas. It offers a comprehensive overview of the most common skin diseases in specific tribes, providing a full clinical guide on the dermatologic signs and symptoms in these individuals. Additionally, the book complements the clinical standpoint with an anthropologic perspective, examining the impact of dermatologic diseases in indigenous people and the different meaning of these diseases in their lives. Most of the material presented in this Atlas was collected in the Xingu Program, a project created in 1965 by the Federal University of São Paulo, Brazil, and devoted to providing medical care to indigenous people from the Upper Xingu region, in the heart of the Amazon rainforest. Thus, the content is primarily applicable to South American indigenous people. However, the common characteristics of the isolation and non-urbanization of these communities, as well as the anthropologic perspective adopted here, allow the content to be extrapolated to other indigenous peoples worldwide. This Atlas will be a novel and valuable resource for health professionals who work with indigenous peoples, especially in geographic areas where dermatologists are not always readily available.

About the Author

Marcos César Floriano: MD (1991), MSc in Dermatology (2000) and PhD in Sciences(2014) by the Federal University of São Paulo (UNIFESP), Brazil. Specialization in Dermatology by the Brazilian Society of Dermatology (1995) and in Leprosy by the Brazilian Society of Hansenology (1997). Assistant doctor, head of leprosy group and head of indigenous people health clinic at Department of Dermatology, UNIFESP. Professor and coordinator of undergraduate course in Medicine – Universidade Nove de Julho.
Jane Tomimori: MD (1983), MSc in Dermatology (1992) and PhD in Sciences(1995) by the Federal University of São Paulo (UNIFESP), Brazil. Specialization in Dermatology by the Brazilian Society of Dermatology (1987). Post-doctoral fellowship in Dermatology at Universität Müster, Germany. Professor of Medicine and deputy headship of the Department of Dermatology, UNIFESP. Member of the editorial board of Anais Brasileiros de Dermatologia and International Journal of Dermatology.
Douglas Antonio Rodrigues: MD (1979), specialization in Social and Preventive Medicine (1983) and PhD in Public Health (2010) by the Federal University of São Paulo (UNIFESP), Brazil. Head of Xingu Program, a program from UNIFESP devoted to provide health care to indigenous people from the Xingu region, Amazon Forest. Head of the Special Interest Group in Indigenous Health and manager of the indigenous people health clinic – UNIFESP.
Sofia Beatriz Machado de Mendonça: MD by Federal University of São Paulo (1983), specialization in Social and Preventive Medicine (1983), MSc in Social Sciences by PUC-SP (1996). Head of Indigenous and non-indigenous human resources department – Xingu Program

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DNA and Histone Methylation as Cancer Targets (Cancer Drug Discovery and Development) 1st ed. 2017 Edition

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This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

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Oncology

Pocket Book for Simulation Debriefing in Healthcare 1st ed. 2018 Edition

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This book is a concise manual on debriefing techniques in a clinical educational context. It presents the most popular debriefing techniques and, hence, can be used as a reference manual by educators to help them achieve their intended debriefing objectives. The overarching objective of debriefing is to promote reflection and improve patient safety awareness at an individual and a team level. This book provides clear explanations of what constitutes a valuable and effective debriefing, and presents the various approaches that can be used and how debriefing differs from feedback. It includes key recommendations on aspects that directly or indirectly impact debriefing with different populations of learners such as students or qualified healthcare professionals of various levels of seniority. This book can also be used as a survival guide for both simulation educators and clinicians during debriefings. It includes several useful sections explaining the different phases of a debriefing session, which help learners develop and consolidate their knowledge, and identify potential knowledge or performance gaps and near misses. The underlying philosophy of this book is to also promote profound respect for the trainee by using a non-offensive debriefing approach. Debriefing facilitators will appreciate the several key sentences that will help them lead and engage their learners in the various phases of expressing their emotions and analyzing their experience and actions.

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