Since the cloning of the cystic fibrosis transmembrane conductance re- lator (CFTR) nearly a decade ago, cystic fibrosis (CF) research has witnessed a dramatic expansion into new scientific areas. Basic researchers, clinicians, and patients increasingly rely on fundamental techniques of genetics, molecular biology, electrophysiology, biochemistry, cell biology, microbiology, and immunology to understand the molecular basis of this complex disease. Research into the pathophysiology of CF has established numerous paradigms of ion channel dysfunction that extend from inflammation and infection in the airways of patients to basic mechanisms of protein processing and regulation in intracellular components. With these rapid advances has come an increasing need for research scientists to understand and utilize a growing array of basic laboratory tools. This volume of Methods in Molecular Medicine, Cystic Fibrosis Methods and Protocols satisfies that need by providing detailed protocols for the laboratory techniques used throughout CF research. From electrophysiology and cell biology, to animal models and gene therapy, the comprehensive set of methods covered here provide step-by-step instructions needed for investigators to incorporate new approaches into their research programs. Contributions have been chosen to reflect the rich diversity of techniques and to provide a cohesive framework for understanding challenges that are currently at the forefront of CF research. It is hoped that this volume will serve as a valuable reference that will not only foster interdisciplinary investigations into current problems encountered in CF, but also facilitate the translation of new scientific discoveries into clinical solutions.
Advances in Pulmonary Medicine: Research and Innovations
This book discusses a wide range of investigations and practice-oriented advances in pulmonary medicine and critical care.
Pulmonary diseases are a major cause of hospitalization and mortality, affecting millions of people worldwide. Addressing a range of topics, including chronic obstructive pulmonary disease, sleep apnea, and lung cancer, the book offers insights into the disease mechanisms and risk factors, along with practical aspects concerning the maintenance of quality of life, adherence to therapy, and palliative treatment and care. Further, it explores diagnostic and treatment approaches to respiratory dysfunction and respiratory failure, highlighting the beneficial effects of good sleep quality in chronic pulmonary conditions and lung transplant patients. The book also presents novel experimental research on the cellular voltage-gated sodium channels in the mechanism of pathological cough, which is particularly relevant for future targeted antitussive therapy. Lastly, it addresses the epidemiological aspects of pulmonary infections.
As such, this book is a valuable resource for medical scholars, clinicians, family physicians, and other professionals seeking to improve the management of respiratory diseases.
Entry Level Exam Review for Respiratory 2nd Edition
This examination review book provides a personalized study plan for candidates preparing for the National Board for Respiratory Care (NBRC) Entry-Level Examination. It presents an exhaustive review of the test matrix, including over 850 questions and analyses based on the 1998 NBRC Entry-Level Examination Matrix. A chapter on test-taking strategies is designed to build self-confidence, discusses when and how to guess, and explains how to think “the NBRC way.” Each question contains a keyed answer, detailed analysis about the question, and a list of references for further study. Detailed scoring forms are available throughout the book to assist candidates in evaluating strengths and weaknesses, and for assessing progress while working through the book. Each question is also linked to a specific examination matrix item allowing candidates to become familiar with the test matrix. A timetable is also included to help the candidates organize the time and activities.
HRCT in Interstitial Lung Disease: Instructive Case Studies 1st ed
With the aid of a series of instructive case studies, this book presents the characteristic high-resolution computed tomography (HRCT) findings seen in the group of disorders referred to as interstitial lung disease. The first, introductory part of the book explains the role of the multidisciplinary team in diagnosis and differential diagnosis and discusses basic pulmonary differential diagnosis, radiologic anatomy, and HRCT patterns. The second part is organized according to the four dominant types of HRCT pattern encountered in interstitial lung disease: low attenuation, linear opacities, nodular, and high attenuation. Within this classification, each disorder is introduced using a specific case, with detailed information on patient history, course of the illness, and laboratory and pulmonary function tests. HRCT findings are then presented, together with reflections of the multidisciplinary team, comprising a radiologist, a pulmonologist, and a pathologist. At the end of each case, comments are made on differential diagnosis, highlighting the role of HRCT. The book will be of high value for radiologists and pulmonologists at all levels of experience.
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Interventions in Pulmonary Medicine 2nd ed
This new edition offers comprehensive coverage of all areas of interventional pulmonology, a minimally invasive endoscopic method for diagnosing and treating lung disorders. The text is divided into eight sections on the major areas of interventional pulmonology, including basic endoscopy, lung cancer staging, and interventional bronschoscopy in asthma and emphysema. Chapters then explore specific procedures and techniques, including medical thoracoscopy, flexible and rigid bronchoscopy, endobronchial ultrasound, and electromagnetical navigation with coverage of history, indications and contraindications, and up-to-date evidence-based reviews. In recent years there have been many advances in interventional pulmonology, the most significant relating to lung cancer early diagnosis and late-stage treatment. Two new chapters on lung cancer epidemiologic changes and personalized lung cancer treatment explore new methods for maximizing patient care for an increasingly prevalent disease. This inclusive volume concludes with a look towards the future of interventional pulmonology and experimental techniques currently being tested. Interventions in Pulmonary Medicine, Second Edition, is a must have for pulmonologists, endoscopists, pulmonary oncologists, ENT physicians, thoracic surgeons, anesthesiologists, and intensive care specialists and their teams.
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Principles and Practice of Interventional Pulmonology
Principles and Practice of Interventional Pulmonology provides a comprehensive text covering all aspects of Interventional Pulmonology. Providing both pathophysiologic background as well as illustrated and clear instruction on how procedures ought to be performed, this text will be of great value to interventional pulmonologists, thoracic surgeons, surgical oncologists, and interventional radiologists.
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This is a book for clinician educators. It offers modern, evidence-based practices to use in teaching learners at a range of levels, with an emphasis on concrete strategies that teachers can implement in their own clinical practices as well as in small and large group settings.
Medical education is rapidly changing with emerging evidence on best practices and a proliferation of new technologies. As strategies for effectively teaching medical learners evolve, it is important to understand the implications for Pulmonary, Critical Care, and Sleep Medicine (PCCM). This text is structured to allow easy access to the reader. Chapters are organized around level of learner (e.g., medical student to PCCM fellow to practicing physicians) as well as the location of teaching. Given the variety of clinical settings in which PCCM physicians teach, specific consideration of best practices, broad changes in curricular design and pedagogy are considered in different clinical contexts.
Each chapter begins with a focus on why the topic is important for clinician educators. A review of the available evidence and relevant medical education theory about the topic follows, with examples from specific studies that provide insight into best practices regarding the concepts and topics discussed in the chapter. For chapters focusing on learners, different environments are considered and similarly, if the focus is on the learning environment, attention is paid to the approach to different learners. Each chapter ends with a summary of the primary points from the chapter and concrete examples of how clinician teachers can put the concepts discussed in the chapter into practice. This is an ideal guide for educators in pulmonary, critical care, and sleep medicine.
Kendig’s Disorders of the Respiratory Tract in Children 9th Edition
Now in a fully updated 9th Edition, Kendig’s Disorders of the Respiratory Tract in Children, by Drs. Robert Wilmott, Andrew Bush, Robin Deterding, and Felix Ratjen, continues to provide authoritative, evidence-based information to residents, fellows, and practitioners in this wide-ranging specialty. Bringing key knowledge from global experts together in one easy-to-understand volume, it covers everything from the latest basic science and its relevance to today’s clinical issues, to improving patient outcomes for the common and rare respiratory problems found in newborns and children worldwide.
- Uses succinct, straightforward text, numerous tables and figures, summaries at the end of each chapter, and more than 500 full-color images to convey key information in an easy-to-digest manner.
- Contains new chapters reflecting expanding knowledge on the respiratory complications of Down syndrome and other genetic disorders, modern molecular therapies for cystic fibrosis and asthma, and pulmonary embolism and thromboembolic disease.
- Includes access to a new video library with demonstrations of key procedures.
- Features a new templated format with more descriptive headings and bulleted text for quick reference and navigation.
- Covers today’s key issues, including the genetic basis of respiratory disease, new and emerging respiratory infections, interstitial lung diseases in infants and young children, technology and diagnostic techniques for pulmonary function tests, emerging lung infections, and new therapies for cystic fibrosis and asthma.
- Provides up-to-date instruction on important procedures, such as bronchoscopy and pulmonary function testing.
- Highlights the knowledge and expertise of three new editors, as well as more than 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery.
- Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
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Oxford Desk Reference: Respiratory Medicine (Oxford Desk Reference Series) 1st Edition
In the era of evidence-based medicine, clinicians draw upon a vast resource of research-based evidence to guide their practice. However, finding this information is not always easy, particularly when it is most needed. In the case of respiratory medicine which covers more than 40 individual conditions, the research-based evidence may be limited and/or disproportionate to the incidence of the condition. Guidelines are available but difficult and time consuming to find.
This book is designed to overcome this problem. Many of the key recommendations to be found in current evidence-based guidelines are presented in a uniform and accessible format. The same format has been used for expert opinion on best practice where the evidence base is limited. The design of this book makes locating the information needed both quick and simple, and the succinct yet easy-to-read nature of the text means that key points can be reviewed and assimilated rapidly. The text is enhanced by a number of summary boxes and tables for quick reference to the key points covered in the narrative. A large number of these sections also have radiological images illustrating the relevant abnormalities. Written by experts in their field, this book presents a succinct overview based on both best practice and available research evidence.
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Respiratory Ailments in Context (Advances in Experimental Medicine and Biology)
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This book tackles the role of interrelated conditions in the manifestation and course of pulmonary ailments. The articles run the gamut from basic to clinical science on such topics as airway allergy challenges, pulmonary dysfunction due to exposure to environmental pollution, molecular and functional aspects of smoking in lung carcinogenesis and in obstruction-related respiratory disorders, and others. Attention is directed to the developments in rehabilitative and lifestyle interventions in chronic disabilities, particularly involving neuromotor and stress-related conditions which, with advancing age, may lead to the deterioration of ventilation, with hypoxic sequelae. Enhanced research and awareness concerning the lung health drive better treatments and quality of life. Clinical insights presented in the book underscore a major role played by the science in transmuting biomedical knowledge into a better patient management. The volume is addressed to clinicians, researchers, physiotherapists, and other healthcare professionals engaged in effective patient care and therapy.