Category: Toxicology

Barile’s Clinical Toxicology: Principles and Mechanisms 3rd Edition

Barile’s Clinical Toxicology: Principles and Mechanisms 3rd Edition

Barile’s Clinical Toxicology: Principles and Mechanisms 3rd Edition

As with the two previous editions, Barile’s Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. With special emphasis placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs, the new edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure.

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The new edition presents the latest, up-to-date protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology. In addition, the effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered.

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The Illustrated Dictionary of Toxicologic Pathology and Safety Science

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists.

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With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings.

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Regulatory Toxicology, Third Edition

Regulatory Toxicology, Third Edition

Regulatory Toxicology, Third Edition

This practical book provides toxicologists with essential information on the regulations that govern their jobs and products. Regulatory Toxicology, Third Edition is an up-to-date guide to required safety assessment for the entire range of man-made marketed products. Individual chapters written by experts with extensive experience in the field address requirements not only for human pharmaceuticals and medical devices (for which there are available guidances), but for the full range of man-made products. New in this edition are three chapters addressing Safety Data Sheet Preparation, Regulatory Requirements for GMOs, and Regulatory Requirements for Tobacco and Marijuana. The major administrative divisions for regulatory agencies and their main responsibilities are also detailed, as are the basic filing documents the agencies require.

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Coverage includes food additives, dietary supplements, cosmetics, over-the-counter drugs, personal care and consumer products, agriculture and GMO products, industrial chemicals, air and drinking water regulations and the special cases of California’s Proposition 65, requirements for safety data sheets, and oversight regulations. Both US and international requirements are clearly presented and referenced. In one volume, those who have regulatory responsibility in companies, lawyers, educators, and those selling these materials in the marketplace can learn about regulatory requirements and how to meet them.

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Handbook of Forensic Toxicology for Medical Examiners 2nd Edition

Handbook of Forensic Toxicology for Medical Examiners 2nd Edition

Handbook of Forensic Toxicology for Medical Examiners 2nd Edition

Forensic professionals, particularly medical examiners―often working through heavy caseloads―require quick and easy access to reliable sources of information to help interpret toxicology results. While several in-depth resources are available, they are often large, cumbersome, and contain more information than is often needed.

The Handbook of Forensic Toxicology for Medical Examiners is a concise handbook referencing the most common toxic substances and their reported non-toxic, toxic, and lethal concentrations, making it an ideal text for quick reference in the lab or autopsy room.

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Features of the Second Edition:

    • Explains the principles of postmortem toxicology and the factors which must be considered
    • Provides tables of toxicologic data for over 200 commonly encountered substances, including drugs of abuse, poisons, prescription drugs, and over-the-counter medications
    • Includes discussion and description of the novel psychoactive drugs―including synthetic opioids, cannabinoids, stimulants and hallucinogens
    • Supplemental appendices provide additional information regarding specimen types and selection, testing methodologies, normal laboratory values, and conversion charts

The busy forensic professional needs a concise handbook that provides critical information quickly and accurately. This heavily referenced text offers an easy-to-use format allowing for rapid access for both routine daily use and preparation for courtroom testimony.

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Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk.

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Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions.

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Comprehensive Toxicology 3rd Edition

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Comprehensive Toxicology 3rd Edition

Comprehensive Toxicology, Third Edition, discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation.

Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies.

Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology.

  • Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems
  • Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system
  • Features additional coverage throughout and a new volume on toxicology of the hematopoietic system
  • Presents in-depth, comprehensive coverage from an international author base of domain experts

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Oxford Desk Reference: Toxicology (Oxford Desk Reference Series) 1st Edition

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Oxford Desk Reference: Toxicology (Oxford Desk Reference Series) 1st Edition

Overdose and poisoning are one of the most frequent acute medical presentations seen in emergency departments, and high dependency and intensive care facilities. The Oxford Desk Reference: Toxicologyprovides an authoritative guide for the management of patients with poisoning. Each chapter includes key clinical features and potential treatment options to help physicians to assess the potential severity of the poisoned patient and provide the optimum clinical care.

A reader-friendly layout ensures that information is easy to find and assimilate, and topics are self-contained to aid quick diagnosis. Presented in an easy-to-use double-page spread format, highly bulleted and concise, the Oxford Desk Reference: Toxicology is ideal for quick referral when an acute problem arises.

Contributions from the leading figures in toxicology make this book indispensable for all those involved with the management of poisoned patients, especially trainees and consultants working in emergency medicine, acute medicine, and critical care.

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Metal Allergy: From Dermatitis to Implant and Device Failure 1st ed. 2018 Edition

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This volume has been compiled in response to the ongoing revolution in our understanding of metal contact allergy, and the ensuing challenge this has created for clinicians and others to synthesize large amounts of sometimes contradictory data. It opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, and detailed sections are devoted to hypersensitivity to metal implants (which may be associated with device failure and/or dermatitis), metal allergy in select patient populations, and less frequently encountered manifestations of metal allergy.

The prevalence of metal allergy in the general population is high: up to 17% of people are allergic to nickel, and 1–3% to cobalt and chromium. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. As metals are ubiquitous, this book will be an indispensable reference text for a wide range of clinicians and investigators, meeting the needs of all who are interested in metal allergy and its diagnosis and management.

Basic and Clinical Toxicology of Organophosphorus Compounds

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This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

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