Locoregional Radionuclide Cancer Therapy

Locoregional Radionuclide Cancer Therapy: Clinical and Scientific Aspects 

Locoregional Radionuclide Cancer Therapy

This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach.

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Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed.

This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.

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Applications of FDG PET in Oncology

Applications of FDG PET in Oncology: Best Clinical Practice

Applications of FDG PET in Oncology

This book provides up-to-date guidance on the use of FDG PET to assess the biological activity and treatment response of a wide range of malignancies, including, for example, lung cancer, breast cancer, head and neck cancer, gastrointestinal cancer, and malignant lymphoma. In the era of precision medicine, numerous new anticancer agents, such as molecular targeted agents and immune checkpoint inhibitors, have been developed to improve outcomes in cancer patients. FDG PET plays a key role in evaluating the effects of these novel treatments because it can detect changes in the metabolic activity of tumors before any reduction in their size is visible on other imaging modalities. Accordingly, FDG PET is of prognostic as well as diagnostic value, and allows prompt changes in patient management.

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The book is written by expert clinicians from Japan, where the universal public health insurance system ensures that FDG PET is widely used in routine oncological practice and cancer screening. It represents an unrivaled and comprehensive resource that will be of value for all healthcare professionals in the field of clinical oncology.

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Gunderson and Tepper’s Clinical Radiation Oncology 5th Edition

Gunderson and Tepper’s Clinical Radiation Oncology 5th Edition

Gunderson and Tepper’s Clinical Radiation Oncology 5th Edition

A comprehensive, multidisciplinary resource for the entire radiation oncology team, Gunderson & Tepper’s Clinical Radiation Oncology, 5th Edition, thoroughly covers all aspects of this complex and dynamic field. Concise, templated chapters cover the basic biology of oncologic disease processes as well as updated treatment algorithms, the latest clinical guidelines, and state-of-the-art techniques and modalities. More than 1,000 images―detailed anatomy drawings, radiographic images, and more―provide outstanding visual support for every area of the text.

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  • Divides content into three distinct sections for quick access to information: Scientific Foundations, Techniques and Modalities, and Disease Sites. Disease Site chapters include overviews summarizing the most important issues and concluding discussions on controversies and problems.
  • Features new and expanded content on molecular and cellular biology and its relevance in individualized treatment approaches, stereotactic radiation therapy, radiosurgery, proton therapy, biologic therapy, precision radiation therapy, targeted radiation, dosing guidelines for better quality of life and improved patient outcomes, and more.
  • Includes new chapters on Radiation Physics: Particle Therapy, Interventional Radiology, Radiation Therapy in the Elderly, Palliative Care, Quality and Safety, and Immunotherapy with Radiotherapy.
  • Provides guidance on single-modality and combined-modality approaches, as well as outcome data including disease control, survival, and treatment tolerance.
  • Includes access to videos on Intraoperative Irradiation, Prostate Brachytherapy, Penile Brachytherapy, and Ocular Melanoma.

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Chemotherapy and Immunotherapy in Urologic Oncology

Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider

Chemotherapy and Immunotherapy in Urologic Oncology

This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current chemotherapy and immunotherapy regimens for genitourinary malignancies and discusses indications, outcomes, and toxicities, as well as clinical trial concepts. Each of the book’s chapters offers a bulleted box of clinical pearls on the particular role of the APP.
Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider is a resource for urologists, uro-radiologists, medical clinicians and family practitioners alike, familiarizing its audiences with systemic therapy regimens for urologic malignancies, as well as their expected outcomes and side effects.

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Precision Medicine in Radiation Oncology

Precision Medicine in Radiation Oncology

Precision Medicine in Radiation Oncology

 

Precision medicine takes into account each patient’s specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made.

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Topics covered include:

  • Biologically-guided radiation therapy
  • Informatics for precision medicine
  • Molecular imaging
  • Biomarkers for treatment assessment
  • Big data
  • Nanoplatforms

Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

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Oral Cancer: Evaluation, Therapy, and Rehabilitation

Oral Cancer: Evaluation, Therapy, and Rehabilitation

Oral Cancer: Evaluation, Therapy, and Rehabilitation

Oral Cancer: Evaluation, Therapy, and Rehabilitation edited by prominent Johns Hopkins clinicians and educators Carole Fakhry, Karen Pitman, Ana Kiess, and David Eisele provides a comprehensive, state-of-the-art review on the diagnosis and management of oral cancer. This unique resource fills a void in the literature by exploring surgical and reconstructive issues specific to each subsite of the oral cavity. Important pre- and post-treatment evaluations by dental, speech language pathology, and the oncologic care team are reviewed.

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The comprehensive book is divided into 10 sections, each focused on different facets of the patients’ trajectory. The text starts with epidemiology of oral cavity cancer and discussion of patient populations at increased risk of oral cavity cancer. The book details pre-cancers, multidisciplinary diagnostic evaluations, treatment, post-treatment, recurrent and metastatic oral cancer, and palliative care, concluding with future directions such as chemoprevention. A full spectrum of oral neoplasms are covered in depth, including different types of squamous cell cancer, primary malignancies of the mandible, and sublingual and minor salivary gland malignancies.

Key Features

  • All oral cavity subsites are approached from both an ablative and reconstructive standpoint, with dedicated chapters focused on specific oral cancer reconstructive techniques
  • Discussion of oncologic considerations encompassing radiation and medical oncology including definitive radiation therapy, brachytherapy, adjuvant radiation therapy, and adjuvant chemotherapy/novel therapeutics
  • Clinical pearls cover complications of both surgery and radiation therapy, as well as psychological and dental implications of therapy
  • High-quality illustrations, photographs, and videos further elucidate impacted anatomy and techniques

Residents and clinicians in otolaryngology-head and neck surgery, oral and maxillofacial surgery, head and neck reconstructive surgery, medical oncology, and radiation oncology will benefit from reading this excellent resource. Dentists who wish to further their knowledge about oral cancers will also find it an invaluable reference.

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Lung Cancer Screening 1st Edition

Lung Cancer Screening 1st Edition

Lung Cancer Screening 1st Edition

Lung cancer is the leading cause of cancer-related death among men and women in the U.S. and worldwide. For many decades, lung cancer was the sole cancer among the deadly four without an evidence-based screening method for decreasing mortality. This changed in November 2011, when findings from the National Lung Cancer Screening Trial showed low-dose lung CT screening was more efficacious in reducing deaths in high-risk individuals than conventional radiography. As such, an ever-increasing number of health organizations now recommend this screening protocol.

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Lung Cancer Screening by Mark Parker and esteemed VCU Health colleagues, fulfills the dire need for a comprehensive guide explaining the crucial aspects of lung cancer screenings. The first two chapters lay a foundation with discussion of lung cancer epidemiology and risk factors beyond cigarette smoking. Subsequent chapters cover the fundamentals, with clinical pearls on setting up a successful lung cancer screening program, patient eligibility criteria, imaging variances of tumors in the lungs, screening pros and cons, and interpreting/reporting screening results.

  • The evolution and future of lung cancer screenings
  • Detection and management of unexpected incidental pulmonary and non-pulmonary findings
  • Discussion of test cases utilizing the Lung-RADSTM risk-stratifying system for low-dose chest CT screenings
  • Benefits and potential harms associated with mass lung cancer screening programs including false positive, false negative, and over-diagnosis rates

This state-of-the-art guide is essential reading for radiologists, oncologists, pulmonologists, and internists. It is a must-have bookshelf reference for hospital radiology and oncology departments, in particular for those setting up new lung cancer screening programs.

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Textbook of Clinical Trials in Oncology: A Statistical Perspective

Textbook of Clinical Trials in Oncology: A Statistical Perspective

Textbook of Clinical Trials in Oncology: A Statistical Perspective

There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area.

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The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology.

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Imaging in Clinical Oncology 2nd ed

Imaging in Clinical Oncology 2nd ed

Imaging in Clinical Oncology 2nd ed

This is the second edition of a well-received book reflecting the state of the art in oncologic imaging research and promoting mutual understanding and collaboration between radiologists and clinical oncologists. It presents all currently available imaging modalities and covers a broad spectrum of oncologic diseases for most organ systems.
Today, oncologic imaging faces the challenge of improving and refining concepts for precise tumor delineation and biologic/functional tumor characterization, as well as for purposes of creating individual treatment plans. The concept of radiomics has further advanced the conversion of images into mineable data and subsequent analysis of said data for decision-making support.

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Since the release of the book’s first edition, radiomics has been introduced in oncology studies and can be performed with tomographic images from CT, MRI and PET/CT studies. The combination of radiomic data with genomic features is known as radiogenomics, and can potentially offer additional decision-making support.
This book will be of interest to clinical oncologists with regard to the diagnosis, staging, treatment and follow-up on various tumors affecting the CNS, chest, abdomen, urogenital and musculoskeletal systems.

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The Basics of Cancer Immunotherapy

The Basics of Cancer Immunotherapy

The Basics of Cancer Immunotherapy

This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy.

The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease.   Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems.  Some key features of the book are:

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