Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond

Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond

Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond

This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field.

 

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Precision Cancer Medicine: Challenges and Opportunities

Precision Cancer Medicine: Challenges and Opportunities

Precision Cancer Medicine: Challenges and Opportunities

Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

 

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Gastric Cancer In The Precision Medicine Era: Diagnosis and Therapy

Gastric Cancer In The Precision Medicine Era: Diagnosis and Therapy

Gastric Cancer In The Precision Medicine Era: Diagnosis and Therapy

Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries.  In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies.
The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer.  The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section.
With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer  has been delineated and  molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified.  These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section.  The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of  immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter.

 

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Clinical Progress in Renal Cancer

Clinical Progress in Renal Cancer

Clinical Progress in Renal Cancer

The last few years have seen major advances in all aspects of the understanding and treatment of kidney cancer, particularly the commonest variant clear cell carcinoma of the kidney. This book brings the reader up to date with these developments, covering aetiology, epidemiology, pathogenesis, prognostic factors, presentation, interventional radiology, minimally invasive surgery, surgery for locally advanced tumours and for metasatic disease, adjuvant medical therapies, therapies for advanced disease, radiotherapy and palliation of symptoms. Each chapter is written by acknowledged experts in the field. The reader gains an excellent idea of the state of the art in the treatment of kidney cancer in an accessible format.

 

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Paediatric Oncology, Third edition

Paediatric Oncology, Third edition

Paediatric Oncology, Third edition

This comprehensive and established textbook presents an up-to-date overview of all aspects of managing children with cancer and in its third edition has been completely revised and updated to reflect recent developments in the field. Individual malignancies are given comprehensive coverage, including details of clinical presentation, diagnostic investigations, novel imaging techniques and current management with chemotherapy, radiotherapy and surgery.

Current controversies relating to diagnosis and management – a popular feature of previous editions – are presented in boxes for increased emphasis. Content changes to the new edition include a restructured pathology section and new chapters under separate headings of ‘advances in therapy’ and ‘late effects and supportive care’.
Retaining a European flavour, but incorporating information from American and other national studies to give an objective and comprehensive overview, the third edition of Paediatric Oncology remains invaluable reading for trainee and practising paediatric oncologists, and nurse specialists, world-wide.

 

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Precision Medicine in Cancers and Non-Communicable Diseases

Precision Medicine in Cancers and Non-Communicable Diseases

Precision Medicine in Cancers and Non-Communicable Diseases

The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of “Precision Medicine”. This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer.

Key Features

• Presents the latest trend of cancer management based on precision/predictive medicine approach

• Reviews the latest and up to date literature in the field of Precision Medicine

• Highlights the next generation approach in tackling malignant diseases

• Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine

• Encapsulates a global prospective

 

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Nuclear Medicine in Oncology: Molecular Imaging and Target Therapy

Nuclear Medicine in Oncology: Molecular Imaging and Target Therapy

Nuclear Medicine in Oncology: Molecular Imaging and Target Therapy

This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the clinical application of the conventional imaging agent 18F-FDG in different tumors and neurodegenerative diseases and 18F-Dopa imaging in the nervous system are discussed. Besides the clinical applications of 99mTc labeled radiopharmaceuticals in parathyroid disease, coronary heart disease, myocardial infarction, sentinel lymph node, metastatic bone tumors, liver and gallbladder disease in children are introduced. Finally, the applications of radionuclide 131I on treatments of Graves’ disease and differentiated thyroid cancer and metastases are investigated respectively.

This book is a useful reference for professionals engaged in nuclear medicine and clinical research, including clinical nuclear medicine physicians, nuclear medicine engineers and nuclear medicine pharmacists.

 

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Target Volume Delineation for Pediatric Cancers (Practical Guides in Radiation Oncology)

Target Volume Delineation for Pediatric Cancers (Practical Guides in Radiation Oncology)

Target Volume Delineation for Pediatric Cancers

This handbook is designed to provide the radiation oncologist with clear practical guidance in the delineation of tumor volumes and/or radiation fields for a wide variety of pediatric cancers, including the most frequently encountered malignancies of childhood. This is a guide to designing treatment fields and volumes that may be utilized in the delivery of conformal therapies such as intensity-modulated radiation therapy and proton therapy, the latter being particularly relevant in children. Each chapter focuses on a specific tumor type, providing general guidelines that will assist the reader in delineating the clinical target volume for particular presentations, including patterns of spread. As the target volumes can be complex, detailed illustrations are presented of the volumes in representative cases, contoured slice by slice on the planning CT images. In addition to target volume delineation for conformal treatment, field design setup for conventional approaches is also discussed.

 

 

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Radiation Therapy Techniques for Gynecological Cancers: A Comprehensive Practical Guide

Radiation Therapy Techniques for Gynecological Cancers: A Comprehensive Practical Guide

This book is a practical guide to the use of modern radiation therapy techniques in women with gynecological cancers. Step-by-step instruction is provided on simulation, contouring, and treatment planning and delivery for cancers of the cervix, endometrium, vagina, and vulva. Beyond external beam radiation delivery, full details are presented on three-dimensional brachytherapy at all sites for which it is applicable. Moreover, in-depth guidance is offered on the various advanced techniques of radiation delivery, including intensity-modulated radiation therapy, image guidance for external beam and brachytherapy, and stereotactic body radiotherapy.

Radiation therapy is a critical component of the multidisciplinary management of gynecological tumors. With modern technology, both external beam radiation and brachytherapy can be delivered in a highly conformal way. This requires precise contouring and accurate planning techniques. In clearly describing the indications for and the delivery of quality radiation therapy for gynecological tumors, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and radiotherapy residents.

 

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Radiotherapy and Clinical Radiobiology of Head and Neck Cancer

Radiotherapy and Clinical Radiobiology of Head and Neck Cancer

Common factors that lead to treatment failure in head and neck cancer are the lack of tumour oxygenation, the accelerated division of cancer cells during treatment, and radioresistance. These tumour-related challenges and possible ways to overcome them are covered in this book, authored by three medical physicists and a clinical oncologist who explain how different radiobiological findings have led to the development of various treatment techniques for head and neck cancer. Novel treatment techniques as supported by current scientific evidence are comprehensively explored, as well as the major challenges that arise in the retreatment of patients who have already undergone a form of radiotherapy for primary head and neck cancer.

 

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