Pediatric Radiation Oncology Fifth Edition
Established since 1986 as the definitive text and reference on use of radiation therapy for childhood cancer, Pediatric Radiation Oncology is now in its thoroughly revised and updated Fifth Edition. This edition reviews all significant recent clinical trials—including, for the first time, significant European clinical trials—and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer. This edition also has full-color illustrations throughout.
Each specific tumor type is covered in a chapter that can be read in one sitting. For each tumor type, the book provides complete information on diagnostic techniques, staging, treatment strategy, and when and how to employ radiation therapy. The authors discuss current patient management options and provide recommendations on the best course of treatment.
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This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized.
Oncology of CNS Tumors 3rd ed
This book is an easy-to-use reference that provides ready guidance on the diagnosis and treatment of the full range of tumors of the central nervous system in adults and children. The new edition has been completely revised to reflect the continually evolving landscape of neuro-oncology and provide readers with a thorough update that will inform their clinical practice. Since the previous edition, molecular neuropathology has progressed considerably, leading to a new understanding of specific clinical entities with corresponding changes in treatment concepts. Moreover, tumor biology has become better integrated with clinical neuro-oncology in truly translational efforts. These advances receive detailed attention. In addition, the structure of the book has been adapted to align with the revised 2016 version of the WHO Brain Tumor Classification. Once again, the contributors have been carefully selected as leading experts in the field. Oncology of CNS Tumors is already established as a widely used reference, and this new edition will provide optimal value for highly specialized comprehensive neuro-oncology centers as well as practicing clinicians and researchers.
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Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field’s leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer.
Textbook of Neonatal Hematology-Oncology
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This textbook is both a comprehensive and a quick reference guide to the diagnosis and treatment of hematologic disorders and pediatric oncology. In the field of hematology and neonatology understanding of physiology of a newborn, especially preterm, has posed new challenges in diagnostic as well as therapeutics. The physiological changes occurring at different age, at the time of birth and thereafter, have necessitated understanding the dynamics of changes in neonatal period. This book provides information about the treatment of malignancies, mechanisms of action of new therapeutic agents and the current use of molecular prognostic factors. Key points about diagnosis and management of disorders are bulleted for easy reference.The user-friendly, visually stimulating format features numerous tables and ample illustrations, including color plates showing hematologic conditions of neonatals. 1. Hematopoiesis in the Fetus, 2. Development of the Immune System, 3. Developmental Aspects of Hemostasis, 4. Effects of Maternal Iron Deficiency Anemia and Iron Supplementation on Fetus, 5. Materno-fetal Hematological Interactions, 6. Physiologic Anemia of Newborn and the Anemia of Prematurity, 7. Immune Hemolytic Anemia in the Newborn, 8. Anemia in Newborn Following Hemorrhage, 9. Bone Marrow Failure Syndromes in the Neonate, 10. Non-immune Hemolytic Anemia in the Neonate, 11. Approach to a Bleeding Neonate, 12. Vitamin K Deficiency Bleeding, 13. Disorders of Platelets in Newborn, 14. Disseminated Intravascular Coagulation (DIC) in Newborn, 15. Polycythemia in Neonate, 16. Current Status of Antenatal Diagnosis of Hemoglobin Disorders in India, 17. Antenatal Diagnosis in Hemophilias, 18. Cellular Blood Components in Neonatal Practice, 19. Transfusion Practices in Newborn.Plasma and Plasma Products, 20. Hazards of Transfusion and Safe Transfusion Practices, 21. Leukocyte Disorders of Newborns. 22. Immuno-hematology of Neonatal Sepsis Applications in Septic Newborns, 23. Solid Tumors in the Neonatal Period, 24. Congenital and Neonatal Leukemias, 25. Thrombophilias, Thrombosis in NICU and Antithrombotic Therapy
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Interventional oncology has emerged as an important specialty within cancer care, providing targeted therapy and palliative benefits without the side effects of chemotherapy, surgery and radiation. Covering the principles of current and emerging interventional oncology techniques and detailed diagnosis, staging and treatment algorithms, this book outlines the ways in which these image-guided therapies can inform cancer management strategies. Access to the most current information is vital in this rapidly growing and evolving area of practice. This new edition reflects the most recent clinical data on interventional oncology procedures. Chapters on image guidance and targeting, tumor ablation, embolotherapy, and response assessment have been updated to reflect major technological advances, and new material on microwave ablation and irreversible electroporation has been added. This invaluable resource for interventional radiologists provides essential education and guidance on the full range of minimally invasive image-guided procedures and their integration into comprehensive cancer care.
DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology Eleventh Edition
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Now updated online for the life of the edition,DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 11th Editionkeeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.
Thisunique, continually updated referenceremains the gold standard reference in the field with:
- A focus on immunotherapy throughoutand new chapters on precision oncology and the microbiome.
- Guidance on managing every type of cancer,while incorporating recent treatment advances.
- The most effective strategies for managing every type of cancer by stage of presentation.Balanced, multidisciplinary advicefrom a surgeon, a medical oncologist, and a radiation oncologist.
- Important related topicssuch as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues.
Enhance Your eBook Reading ExperienceRead directly on your preferred device(s),such as computer, tablet, or smartphone.
- Easily convert to audiobook,powering your content with natural language text-to-speech.
Viruses and Human Cancer: From Basic Science to Clinical Prevention
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Research on oncogenic viruses and related human cancers has advanced rapidly in the past decade. Most articles, however, focus on a specific oncogenic virus and cancer. There is consequently a need for a comprehensive, up-to-date monograph that offers broad and integrated knowledge. Viruses and Human Cancer – From Basic Science to Clinical Prevention is designed to meet this need by providing an advanced overview on the basic and clinical aspects of oncogenic viruses and the human cancers that they cause. Virology, virus-induced inflammation and tissue injuries, oncogenic mechanisms, epidemiology, and current and emerging preventive and therapeutic strategies are all discussed in detail. In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.
Concise Manual of Hematology and Oncology
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A real boon for medical practitioners from a number of disciplines, this is a practice-oriented manual of medical oncology and hematology for day-to-day use in caring for patients’ hematologic and neoplastic diseases. It is founded on the longstanding experience of a large specialized university department accustomed to having to provide reliable advice in a broad range of circumstances. The authors have chosen not to give a comprehensive review of the various subjects but have instead focused on practical methods which have proven to be useful in their experience, with special emphasis on standardizing chemotherapy protocols.