Textbook of Clinical Trials in Oncology: A Statistical Perspective

Textbook of Clinical Trials in Oncology: A Statistical Perspective

Textbook of Clinical Trials in Oncology: A Statistical Perspective

There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area.

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The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology.

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Imaging in Clinical Oncology 2nd ed

Imaging in Clinical Oncology 2nd ed

Imaging in Clinical Oncology 2nd ed

This is the second edition of a well-received book reflecting the state of the art in oncologic imaging research and promoting mutual understanding and collaboration between radiologists and clinical oncologists. It presents all currently available imaging modalities and covers a broad spectrum of oncologic diseases for most organ systems.
Today, oncologic imaging faces the challenge of improving and refining concepts for precise tumor delineation and biologic/functional tumor characterization, as well as for purposes of creating individual treatment plans. The concept of radiomics has further advanced the conversion of images into mineable data and subsequent analysis of said data for decision-making support.

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Since the release of the book’s first edition, radiomics has been introduced in oncology studies and can be performed with tomographic images from CT, MRI and PET/CT studies. The combination of radiomic data with genomic features is known as radiogenomics, and can potentially offer additional decision-making support.
This book will be of interest to clinical oncologists with regard to the diagnosis, staging, treatment and follow-up on various tumors affecting the CNS, chest, abdomen, urogenital and musculoskeletal systems.

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The Basics of Cancer Immunotherapy

The Basics of Cancer Immunotherapy

The Basics of Cancer Immunotherapy

This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy.

The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease.   Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems.  Some key features of the book are:

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Encyclopedia of Cancer 3rd Edition

Encyclopedia of Cancer 3rd Edition

Encyclopedia of Cancer 3rd Edition

Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition.

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Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented.

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Encyclopedia of Cancer 4th ed

Encyclopedia of Cancer 4th ed

Encyclopedia of Cancer 4th ed

This work comprehensively describes etiological factors in the development , Progression and metastasis of human cancers, both for hematological malignancies and for solid Tumors. Approaches for the diagnosis as well as for therapies are outlined too. The fourth edition of the “Encyclopedia of Cancer” features a vastly extended number of terms as compared to the previous edition. Previously published entries have enjoyed a vigorous updating and adjustment to current status of knowledge, a large number of new timely entries have been added to consider the amazing progress and modern developments both in basic and clinical aspects of cancer.

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Up-to date and authoritative Essays present a comprehensive picture of topics ranging from pathology,  to clinical oncology, and targeted therapy for personalized cancer medicine for major human cancers, in particular breast cancer, colorectal cancer, prostate cancer, renal cancer lung cancer and hematological malignancies , leukemias and lymphomas. Each author is an international authority for the particular topic, and each entry has been adjusted to an easy-to-follow reader-friendly structure that allows to collect very rapidly essential information. At the same time, these essays should be considered a starting point from which the quest for more detailed information can depart. Extensive cross referencing of essays is an instrument by which the acquisition of the complete picture of a particular topic will be facilitated.

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Liver Cancers: From Mechanisms to Management

Liver Cancers: From Mechanisms to Management

Liver Cancers: From Mechanisms to Management

This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy.   Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these.

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Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding.

This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery

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Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond

Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond

Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond

This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field.

 

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Precision Cancer Medicine: Challenges and Opportunities

Precision Cancer Medicine: Challenges and Opportunities

Precision Cancer Medicine: Challenges and Opportunities

Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

 

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Gastric Cancer In The Precision Medicine Era: Diagnosis and Therapy

Gastric Cancer In The Precision Medicine Era: Diagnosis and Therapy

Gastric Cancer In The Precision Medicine Era: Diagnosis and Therapy

Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries.  In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies.
The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer.  The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section.
With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer  has been delineated and  molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified.  These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section.  The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of  immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter.

 

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Clinical Progress in Renal Cancer

Clinical Progress in Renal Cancer

Clinical Progress in Renal Cancer

The last few years have seen major advances in all aspects of the understanding and treatment of kidney cancer, particularly the commonest variant clear cell carcinoma of the kidney. This book brings the reader up to date with these developments, covering aetiology, epidemiology, pathogenesis, prognostic factors, presentation, interventional radiology, minimally invasive surgery, surgery for locally advanced tumours and for metasatic disease, adjuvant medical therapies, therapies for advanced disease, radiotherapy and palliation of symptoms. Each chapter is written by acknowledged experts in the field. The reader gains an excellent idea of the state of the art in the treatment of kidney cancer in an accessible format.

 

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