Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells.

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From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer.

  • Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding
  • Updates current trends in the field with pioneering information on drug resistance
  • Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

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Diffusion Weighted Imaging of the Hepatobiliary System

Diffusion Weighted Imaging of the Hepatobiliary System: Techniques and Clinical Applications

Diffusion Weighted Imaging of the Hepatobiliary System

This book presents the core principles and technical aspects of Diffusion Weighted Imaging (DWI), as well as pearls and pitfalls concerning the imaging technique’s application to the hepatobiliary system. All technical aspects and clinical applications discussed focus on the related anatomical region and its pathologies.

Though DWI is frequently used in the abdomen and pelvis, its clinical role is still evolving, especially for the diagnostic workup of oncologic patients. Although certain efforts have been undertaken to standardize and provide imaging guidelines for different clinical indications, the standardisation and clinical validation of quantitative DWI-related biomarkers are still works in progress.

Addressing this gap, the book offers a useful tool for radiologists with a particular interest in abdominal radiology, as well as for radiology residents.

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Clinical Challenges and Images in Gastroenterology: A Diagnostic Guide

Clinical Challenges and Images in Gastroenterology: A Diagnostic Guide

Clinical Challenges and Images in Gastroenterology

“Clinical Challenges & Images in Gastroenterology — A Diagnostic Guide” presents 50 real-life cases to illustrate an evidence-based approach for the diagnosis, investigation and management of gastrointestinal diseases commonly encountered in everyday practice, with a special focus on the interpretation of endoscopic and radiological images. This book provides a pragmatic approach for medical students, residents, specialist trainees and specialists alike who have an interest in gastroenterology.

Other healthcare providers, such as general practitioners, nurses and dieticians, will also benefit from these case illustrations. The authors of this book are based at the Institute of Digestive Disease, Chinese University of Hong Kong. This institute has contributed to major breakthroughs that have improved the clinical management of digestive diseases including, but not limited to, the advent of endoscopic therapies and minimally invasive surgery, molecular diagnostic tools for cancers and inflammatory bowel disease, and the development of novel treatments for acid-peptic disease and viral hepatitis.

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Liver Diseases: A Multidisciplinary Textbook

Liver Diseases: A Multidisciplinary Textbook

Liver Diseases: A Multidisciplinary Textbook

This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation.

The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation.

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CURRENT Diagnosis & Treatment Gastroenterology, Hepatology, & Endoscopy 3rd Edition

CURRENT Diagnosis & Treatment Gastroenterology, Hepatology, & Endoscopy 3rd Edition

CURRENT Diagnosis & Treatment

CURRENT Diagnosis & Treatment

The ultimate clinical companion for managing digestive and liver diseases―now revised and updated!

Part of the acclaimed CURRENT series, this trusted, practical resource reviews how to diagnose and treat the entire spectrum of digestive tract and liver disorders.

Authored by faculty physicians at Harvard Medical School and Brigham and Women’s Hospital, CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy features a streamlined, consistent presentation, with each chapter outlining the essentials of diagnosis for each condition.

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The third edition of this skill-building guide incorporates the latest research and takes you through therapeutic advances in Barrett’s esophagus, eosinophilic esophagitis, esophageal motility disorders, inflammatory bowel disease, and other conditions. Altogether, CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy is more current―and more indispensable―than ever. Page after page, it puts the most important insights on managing digestive and hepatic diseases in the palm of your hand.

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Neonatal and Pediatric Liver and Metabolic Diseases: Clinical Casebook

Neonatal and Pediatric Liver and Metabolic Diseases: Clinical Casebook

Neonatal and Pediatric Liver and Metabolic Diseases: Clinical Casebook

Neonatal and Pediatric Liver and Metabolic Diseases: Clinical Casebook

This book is written to simplify complex topics of neonatal and pediatric liver and metabolic diseases which are encountered by clinicians on a day to day basis. Neonatal and early pediatric liver diseases are very much different from adult liver diseases. Most of them are either structural diseases or genetically modulated metabolic disorders affecting liver. They all look same; however the underlying etiology could be quite different. This book thoroughly covers various neonatal and pediatric liver and metabolic diseases through a unique clinical case based approach via a vast clinical experience of the author.

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The book presents more than 50 unique cases and presents real life learning scenario with various examples facilitating better understanding of the disease and the ways to analyze it. The book uses a simple language and presents line diagrams and algorithms facilitating learning. This book shall be a valuable resource for practicing general pediatricians, pediatric residents and gastroenterologists with involvement in pediatric liver and liver related metabolic diseases.

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Atlas of Diagnostic Endoscopy, 3rd Edition

Atlas of Diagnostic Endoscopy, 3rd Edition

Atlas of Diagnostic Endoscopy, 3rd Edition

This book is a compilation of endoscopic images of the upper gastrointestinal tract. The 3rd edition is enriched with high-resolution digital images highlighting the classification and staging of endoscopically relevant diseases. Serial documentation of diseases and procedures like corrosive injury, variceal obliteration, peptic ulcer etc. provides a complete, informative and interesting perspective. Rare conditions like Dieulafoy’s disease and Gastric antral vascular ectasia (GAVE) have been extensively discussed along with common diseases of the GI tract. This book outlines the technique and interpretation of endoscopic images proving to be a helpful guide to endoscopy practitioners.

Key Features

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  • Explores various GI tract diseases through coloured, high resolution clinical photographs.
  • Serves as a useful reckoner for trainee endoscopists and practitioners pursuing gastroenterology or gastrointestinal endoscopy.
  • The text is updated with tables, flowcharts, classifications and international treatment guidelines.

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Gastrointestinal Emergencies: Evidence-Based Answers to Key Clinical Questions

Gastrointestinal Emergencies: Evidence-Based Answers to Key Clinical Questions

Gastrointestinal Emergencies: Evidence-Based Answers to Key Clinical Questions

This book answers key questions asked by emergency clinicians faced with complex gastrointestinal and abdominal pain presentations.  Instead of a traditional format that includes epidemiology, pathophysiology, diagnosis, and treatment options, this book takes an approach that mirrors the way clinicians interact with patients – by asking and answering specific clinical care questions.

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The book is organized into sections by presentation – gastrointestinal bleeding, for example – each of which contains chapters on specific questions, such as “What is the best clinical risk score for low risk GIB patients?” Each clinical question comes with a detailed, evidence-based response and a summary that gives best practices, recommendations, and references. Additionally, at the end of each section is a chapter titled “Expert Corner,” which asks the same clinical questions to a surgical or gastrointestinal specialist and includes key pearls these experts have for emergency medicine practitioners. Gastrointestinal Emergencies: Evidence-Based Answers to Key Clinical Questions is an essential guide for emergency medicine physicians, residents, and medical students who want to review and improve their care of acute gastrointestinal emergencies.

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Liver Cancers: From Mechanisms to Management

Liver Cancers: From Mechanisms to Management

Liver Cancers: From Mechanisms to Management

This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy.   Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these.

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Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding.

This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery

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Clinical Epidemiology of Chronic Liver Diseases

Clinical Epidemiology of Chronic Liver Diseases

Clinical Epidemiology of Chronic Liver Diseases

This book emphasizes the clinical epidemiology of chronic liver diseases with a specific focus on the methodology of the discussed studies. The whole spectrum of liver diseases is covered, from chronic hepatitis B and C, to hepatocellular carcinoma, alcoholic and non-alcoholic fatty liver diseases and autoimmune and cholestatic liver diseases.

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Readers will find the most up-to-date information on clinical epidemiology of hepatology, and will also be able to learn about important methodology and biostatistics information. Each chapter contains a summary table at the end of each chapter that highlights the most relevant landmark studies, their main outcomes and the unique features of the methodology.

The book will appeal to both practicing clinicians as well as clinical research investigators.  In addition, this would likely be of interest to medical school or public health school students to learn about hepatology epidemiology, but also some specific fundamentals of clinical research and clinical epidemiology.

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