This volume explores the latest techniques and improved methods used to study important neurobiological and associated neuropathological conditions. Chapters cover topics such as the application of semiconductor quantum dots as photostable fluorophores used for labeling and tracking; GCaMP6 transcranial imaging to monitor neural activity; the patch-clamping technique allowing simultaneous monitoring of membrane currents and optical signals; and quantifying behavioral dysfunction caused by traumatic brain injury (TBI). In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and practical, Basic Neurobiology Techniques is a valuable resource for novel and expert researchers interested in expanding their knowledge of this developing field.
Health care in the twenty-first century requires intensive use of technology in order to acquire and analyze data and manage and disseminate information. No area is more data intensive than the neurointensive care unit. Despite the massive amount of data, however, providers often lack interpretable and actionable information. This book reviews the concepts underlying the emerging field of neurocritical care informatics, with a focus on integrated data acquisition, linear and nonlinear processing, and innovative visualization in the ICU. Subjects addressed in individual chapters are thus wide ranging and encompassing, for example, multimodal and continuous EEG monitoring and data integration, display of data in the ICU, patient-centered clinical decision support, optimization of collaboration and workflow, and progress towards an “integrated medical environment”. All of the nine chapters have been written by international thought leaders in the field.
This richly illustrated book summarizes the state of the art in brain MRI with the 3-Tesla high-field scanner. The aim is to clarify the numerous advantages of using a 3-T high magnetic field MR scanner, especially in terms of sensitivity and specificity. The first section describes techniques for standard MR examination of the brain. Full descriptions are then provided of advanced protocols such as MR angiography, diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), MR spectroscopy, MR tractography, and functional imaging. Differences in diagnostic features when performing these examinations at 3 T and at 1.5 T are highlighted. In addition, safety issues relating to the installation and use of a high-field scanner are discussed. The second section then describes and illustrates in detail each of the main clinical applications of 3-T MRI in the human brain: trauma, stroke, white matter disease, Parkinson’s disease, Alzheimer’s disease, brain tumors, inflammatory disease, psychiatric disorders, etc. A final chapter is dedicated to the evaluation of 7-T MRI within both research and potential clinical settings. The book will be a valuable tool for general radiologists, neuroradiologists, trainees, and technicians.
Clinical Cases in Neurology (In Clinical Practice)
This book presents a selection of neurological clinical cases and tests the reader in order to allow them to gain clinical self-confidence in approaching the case, requesting tests (negotiating test with other specialties e.g. radiology) and also in referring to other specialties. The book examines a range of different clinical scenarios and neurological conditions from multiple sclerosis and degenerative disorders to epilepsy and headache.
The book can serve as a teaching aid in a classroom setting, where teacher introduces the case (“telling the story”, neurological examination) and the students then propose differential diagnoses and further tests. Teacher, when suitable, shows representative test result to students and expects students to interpret scan/test, eventually concluding the case, proposing further referrals and discussing prognosis Each chapter also contains visual aids in the form of Neuroexam, helping the reader gain a quick understanding of the case.
Aimed at trainee neurologists and any non-neurologists who might encounter neurological cases in the clinic, this book is useful for bedside teaching especially when there are not enough available patients on ward.
Nanoceramics in Clinical Use: From Materials to Applications (Nanoscience) 2nd Edition
Since the publication of Biomimetic Nanoceramics in Clinical Use, there have been major advances in the field of nanoceramics for biomedical applications including new materials and the development of applications in drug delivery and gene therapy. This follow up edition is fully revised and updated with the recent progress and includes additional material on bone mineralization processes, new synthesis strategies and applications of nanostructured biocermics to manufacture 3D macroporous scaffolds and as nanovehicles for targeted drug delivery and gene therapies. Written by a world leading expert in biomaterials, the book will appeal to those interested in materials for biomedical applications.
Multiscale Models of Brain Disorders
This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics.
This volume provides a deeper understanding of the diagnosis of brain tumors by correlating radiographic imaging features with the underlying pathological abnormalities. All modern imaging modalities are used to complete a diagnostic overview of brain tumors with emphasis on recent advances in diagnostic neuroradiology. High-quality illustrations depicting common and uncommon imaging characteristics of a wide range of brain tumors are presented and analysed, drawing attention to the ways in which these characteristics reflect different aspects of pathology. Important theoretical considerations are also discussed. Since the first edition, chapters have been revised and updated and new material has been added, including detailed information on the clinical application of functional MRI and diffusion tensor imaging. Radiologists and other clinicians interested in the current diagnostic approach to brain tumors will find this book to be an invaluable and enlightening clinical tool.
This comprehensive, yet practical, text is a ready collection of the most up-to-date information on primary CNS tumors. Authored by a carefully selected group of the world’s leading clinicians and scientists, the book is divided into three sections. The opening chapters cover general principles, including epidemiology, pathogenesis, tumor stem cells, supportive care, complications of therapy, and quality of life. The remaining two sections are comprised of treatment-oriented chapters covering the spectrum of gliomas and rarer tumor types. Each of these chapters presents multi-disciplinary therapeutic approaches and addresses specific disease concerns. Throughout, the authors incorporate the cutting-edge advances in molecular biology and genomics that are revolutionizing neuro-oncology. The result is an important clinical resource which provides evidence-based data and interpretation essential to intelligent therapeutic decision making.
In the last decade neuroscience has matured at a remarkable pace, shedding a far more exacting light on mechanisms of neurophysiology, pathophysiology of injury, neuroendocrinology, neuro-immunology, neuroplasticity, neuropharmacology and neurodegenerative processes. Individuals with acquired brain injury are treated earlier and now achieve far better recovery than in the past.
The fourth edition of this text constitutes a continuation of 20 years of coverage of traumatic brain injury, and broadens the discussion of acquired brain injury. Within TBI, the paradigm shift from an injury occurring at a point in time to a disease entity of a chronic nature is changing the discussion of diagnosis, management, treatment and outcome assessment. Disease specification that differentiates TBIs by the mechanism of injury, the exact nature of the injury, the extent of injury, presence of co-morbidities and their exact nature, gender, age, race, and genome are emerging as crucial. There was a time when cancer was an undifferentiated disease. Disease differentiation has consequently impacted diagnosis, treatment and outcome.
This text is intended to serve as a ready reference tool, contributing to the professional growth of each reader, and stimulating innovation and research. It also promotes the continued refinement in the management of diseases of acquired brain injury.
This comprehensive, up-to-date textbook of modern cervical spine surgery describes the standard and advanced techniques recommended by the Cervical Spine Research Society – European Section (CSRS-E) with a view to enabling both young and experienced surgeons to further develop their skills and improve their surgical outcomes. Success in cervical spine surgery depends on the surgeon’s awareness of the main challenges posed by distinct cervical spine diseases, theoretical understanding of treatment concepts, and knowledge of technical options and the related potential for complications. It is the surgeon who has to merge theory and practice to achieve the desired outcome, in each case appraising the details of surgical anatomy and weighing the challenges and complications associated with a surgical technique against the skills that he or she possesses. This excellently illustrated book, written by key opinion makers from the CSRS-E with affiliated surgeons as co-authors, presents the full range of approaches and techniques and clearly identifies indications, precautions, and pitfalls. It will be a superb technical reference for all cervical spine surgeons, whether orthopaedic surgeons or neurosurgeons.