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Genetics of Rare Autoimmune Diseases

Genetics of Rare Autoimmune Diseases

The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact.

General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet’s disease, Sjogren’s syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.

 

 

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Demonstrating Your Clinical Competence in Cardiovascular and Neurological Conditions

Demonstrating Your Clinical Competence in Cardiovascular and Neurological Conditions

All registered nurses are required to keep portfolios which demonstrate their competence in clinical practice in order to receive re-registration with the Nursing and Midwifery Council. In addition, they are encouraged to seek individual annual appraisals which highlight their progress and areas the require development. This book provides examples and ideas on how to document learning, competence, performance or standards of service delivery. It takes an important clinical theme throughout, providing key information on clinical management from the outset, followed by structured examples of evidence of performance and application of learning in practice, individualised for each clinical theme, focussing on cardiovascular and neurological conditions. It explains how to gather evidence from clinical interactions and other aspects of daily work. All nurses working in primary care with an interest in chronic disease management, especially those who are looking for a more ‘first contact’ work within their role will find this book valuable reading.

 

 

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Infusion Therapy: For Pain, Headache and Related Conditions

Infusion Therapy: For Pain, Headache and Related Conditions

There is a significant gap in current knowledge about infusion therapy for treating different pain, headache and psychiatric conditions. Infusion therapy is now a common practice but there is considerable variation in how the therapy is implemented in different centers which can be both dangerous, if high doses are given, or ineffective, if low doses are given. This book provides a practical guide to infusion therapy for clinicians on how to safely and effectively perform this kind of therapy.

Chapters cover the pharmacology of each medication and evidence in literature regarding indications, contraindications and doses. A recommended algorithm is provided for patient selection, doses, infusion technique/doses and appropriate monitoring.

Infusion Therapy is the first comprehensive, clinical guide to this practice and is an invaluable resource for clinicians in anesthesia, pain medicine, internal medicine  and palliative care. It will also be of interest to researchers and pharmacologists who would like to find out how clinicians use infusions.

 

 

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Principles and Practice of Anesthesia for Thoracic Surgery 2nd ed

Principles and Practice of Anesthesia for Thoracic Surgery 2nd ed

Updated and expanded, this comprehensive new edition captures the considerable evolution in the anesthetic management of patients requiring anesthesia for non-cardiac intrathoracic diagnostic and therapeutic procedures. Major advances addressed include the expanded role of ultrasound beyond trans-esophageal echocardiography, the role of extra-corporeal membrane oxygenation in thoracic anesthesia, and postoperative pain management for thoracic surgery. Chapters are authored by prominent anesthesiologists and feature cases commonly encountered in clinical practice. Authoritative and the leading text in the field, this book will serve as an indispensible guide to practitioners of thoracic anesthesia at all levels.

 

 

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Glaucoma Drainage Devices: A Practical Illustrated Guide

Glaucoma Drainage Devices: A Practical Illustrated Guide

This book offers a comprehensive guide to the use of glaucoma drainage devices (GDDs) in various clinical settings, and covers aspects ranging from the basics to managing complications. The aim of this work is to provide readers with a practical go-to desktop book to assist in and enhance their surgical competence with glaucoma drainage devices.

Starting with the history of GDDs, it addresses various devices, their models and modifications, and highlights their advantages and disadvantages through numerous illustrations. The indications for the drainage devices are discussed in detail, using patient cases with photographs. The book describes the techniques for all devices in detail, which are explained further in accompanyin videos.

After covering the basic techniques, the book provides extensive notes on modifications that may be required in various case presentations such as congenital glaucoma, post-penetrating keratoplasty with extensive peripheral synechiae, and procedure through pars plans etc. Complications and their management are subsequently addressed.

The book is an essential guide to help surgeons match patients to the most suitable device, and to support patients from preparation through post-operative care. Primarily intended for glaucoma surgeons, it offers a valuable resource for fellows in training, and all who have an interest in glaucoma surgery.

 

 

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Basic Concepts in Clinical Biochemistry: A Practical Guide

Basic Concepts in Clinical Biochemistry: A Practical Guide

This book is a practical guidebook in biochemistry, for medical as well as life sciences’ students. The book covers reference values, sample collection procedure and detailed protocol to perform experiments. Each experiment starts with a brief introduction of the protocol, followed by specimen requirements and procedure. The procedures are presented in a very lucid manner and discuss details of calculations and clinical interpretations,The book is divided into 29 chapters, It offers references, general guidelines and abbreviations and provides principles and procedures of clinical biochemistry tests, along with their diagnostic importance.

 

 

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State of the Heart: Exploring the History, Science, and Future of Cardiac Disease

State of the Heart: Exploring the History, Science, and Future of Cardiac Disease

State of the Heart traces the entire arc of the heart, from the very first time it was depicted on stone tablets, to a future in which it may very well become redundant. While heart disease has been around for a while, the type of heart disease people have, why they have it, and how it’s treated is changing. Yet, the golden age of heart science is only just beginning. And with treatments of heart disease altering the very definitions of human life and death, there is no better time to look at the present and future of heart disease, the doctors and nurses who treat it, the patients and caregivers who live with it, and the stories they hold close to their chests.

More people die of heart disease than any other disease in the world and when any form of heart disease progresses, it can result in the development of heart failure. Heart failure affects millions and can affect anyone at anytime, a child recovering from a viral infection, a woman who has just given birth or a cancer patient receiving chemotherapy. Yet new technology to treat heart failure is fundamentally changing just what it means to be human. Mechanical pumps can be surgically sown into patients’ hearts and when patients with these pumps get really sick, sometimes they don’t need a doctor or a surgeon―they need a mechanic.

 

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Congenital Heart Disease: The Nursing Care Handbook

Congenital Heart Disease: The Nursing Care Handbook

This book provides the theoretical and practical basis of technical nursing in congenital heart disease; it is intended for nurses and nursing students, and for anyone involved in the treatment of these patients. The improvements in diagnosis and management of patients with congenital heart disease (CHD) are due to the recent advances in cardiac surgery and interventional cardiology and have meant that an increasing number of infants are reaching adolescence and adulthood.  This manual is a practical and easy-to-use guide, which promotes effective cooperation between health professionals.

Congenital heart disease is a disorder that is present at birth, and studies show that the incidence is around eight cases per thousand live births. The heart is formed during the first four – ten weeks of gestation, and alterations to this process can affect normal development, leading to heart defects. There are various types of heart defects: abnormalities that affect a single part of the heart (for example a valve) but also, highly complex abnormalities where there is severe damage to the cardiac architecture. The seriousness of the disease and the effects on child health vary: some forms have no real impact on child health and allow a normal life, while others are incompatible with life.

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CT of the Heart (Contemporary Medical Imaging) 2nd Edition

CT of the Heart (Contemporary Medical Imaging) 2nd Edition

This book is a comprehensive and richly-illustrated guide to cardiac CT, its current state, applications, and future directions. While the first edition of this text focused on what was then a novel instrument looking for application, this edition comes at a time where a wealth of guideline-driven, robust, and beneficial clinical applications have evolved that are enabled by an enormous and ever growing field of technology. Accordingly, the focus of the text has shifted from a technology-centric to a more patient-centric appraisal. While the specifications and capabilities of the CT system itself remain front and center as the basis for diagnostic success, much of the benefit derived from cardiac CT today comes from avant-garde technologies enabling enhanced visualization, quantitative imaging, and functional assessment, along with exciting deep learning, and artificial intelligence applications. Cardiac CT is no longer a mere tool for non-invasive coronary artery stenosis detection in the chest pain diagnostic algorithms; cardiac CT has proven its value for uses as diverse as personalized cardiovascular risk stratification, prediction, and management, diagnosing lesion-specific ischemia, guiding minimally invasive structural heart disease therapy, and planning cardiovascular surgery, among many others. This second edition is an authoritative guide and reference for both novices and experts in the medical imaging sciences who have an interest in cardiac CT.

 

 

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Transforming the Heart of Practice: An Organizational and Personal Approach to Physician Wellbeing

Transforming the Heart of Practice: An Organizational and Personal Approach to Physician Wellbeing

This unique, step-by-step guide offers a comprehensive exploration of burnout and physician wellbeing, a vital issue that steadily has become widely discussed in the professional and mainstream press.   More than twenty chapter authors contribute to this multidimensional volume, including physicians, psychologists, researchers, healthcare administrators, chaplains, professional coaches, and counselors. Section one of the book establishes context, provides a brief overview of the phenomenon of physician burnout, establishes its validity, and makes a case for the reason it has emerged as a critical issue in American healthcare.  Section two provides a rationale for healthcare institutions (hospitals, physician groups, medical associations) to make a commitment to physician wholeness, while section three then starts the process of delineating a step-by-step curriculum to address the dilemma, providing additional detail and personal experience direct from the frontlines of combatting burnout. Section four focuses on developing and sustaining a healthy professional culture that is aligned with the mission of the organization, and section five addresses the spiritual component of physician wholeness,   Section six concludes the book with two personal essays that poignantly express the nature of two common experiences affecting physicians that require uncommon insight, patience, courage. Transforming the Heart of Practice is a major contribution to the literature and will serve as an invaluable resource for anyone concerned with addressing this crisis in American healthcare.

 

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