The Illustrated Dictionary of Toxicologic Pathology and Safety Science

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists.

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With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings.

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Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk.

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Toxicologic Pathology: Nonclinical Safety AssessmentSecond Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions.

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Porth’s Pathophysiology: Concepts of Altered Health States Tenth, North American Edition

Porth’s Pathophysiology: Concepts of Altered Health States Tenth, North American Edition

Porth’s Pathophysiology: Concepts of Altered Health States Tenth, North American Edition

The 10th edition of Porth’s Pathophysiology: Concepts of Altered Health States continues a legacy of excellence by providing comprehensive, nursing-focused coverage designed to help grasp both the physical and psychological aspects of altered health. The book’s unique emphasis on “concepts” of altered health states, as opposed to factual descriptions of diseases and disorders, helps students grasp both the physical and psychological aspects of altered health.

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Make the most of your pathophysiology course and master the knowledge to ensure clinical success. Trusted for more than 30 years and updated to reflect today’s nursing challenges, this engaging text makes complex concepts accessible and helps you easily and confidently grasp normal body function, the effects of disease on body systems, and the body’s ability to compensate and adapt. This edition also considers the many technological advances that allow healthcare providers to diagnose earlier and with more accuracy.

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Bone Marrow Pathology 5th Edition

Bone Marrow Pathology 5th Edition

Bone Marrow Pathology 5th Edition

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Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as a practical resource with “problems and pitfalls” highlighted throughout to aid laboratory diagnosis.

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Cardiac Pathology: A Guide to Current Practice 2nd Edition

Cardiac Pathology: A Guide to Current Practice 2nd Edition

Cardiac Pathology: A Guide to Current Practice 2nd Edition

his updated second edition provides a comprehensive overview of cardiac pathology. Clear illustrations of the common styles of dissection are provided along with the normal anatomy and histology. The chapters cover autopsy heart examination, ischemic heart disease, myocarditis, sudden death, valvular disease, transplant pathology, cardiomyopathy, cardiac neoplasia and congenital heart disease with a clear analysis of diagnostic criteria (macroscopic, microscopic and genetic) for both common cardiac diseases and those of less common types. The text is accompanied by high quality macroscopic and microscopic images and references to other specialty data sources.

Cardiac Pathology: A Guide to Current Practice is aimed at established pathologists and trainees, as well as any clinician with an interest in cardiac disease. It will be of value to those working in cardiac surgery, cardiology and those in the autopsy/forensic fields.

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Error Reduction and Prevention in Surgical Pathology 2nd ed

Error Reduction and Prevention in Surgical Pathology 2nd ed

Error Reduction and Prevention in Surgical Pathology 2nd ed

The 1st edition of Error Reduction and Prevention in Surgical Pathology was an opportunity to pull together into one place all the ideas related to errors in surgical pathology and to organize a discipline in error reduction. This 2nd edition is an opportunity to refine this information, to reorganize the book to improve its usability and practicality, and to include topics that were not previously addressed.

This book serves as a guide to pathologists to successfully avoid errors and deliver the best diagnosis possible with all relevant information needed to manage patients. The introductory section includes general principles and ideas that are necessary to understand the context of error reduction. In addition to general principles of error reduction and legal and regulatory responsibilities, a chapter on regulatory affairs and payment systems which increasingly may be impacted by error reduction and improvement activities was added.  This later chapter is particularly important in view of the implementation of various value-based payment programs, such as the Medicare Merit-Based Incentive Payment System that became law in 2015. The remainder of the book is organized in a similar manor to the 1st edition with chapters devoted to all aspects of the test cycle, including pre-analytic, analytic and post-analytic.

The 2nd Edition of Error Reduction and Prevention in Surgical Pathology serves as an essential guide to a successfully managed laboratory and contains all relevant information needed to manage specimens and deliver the best diagnosis.

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Fundamentals of Applied Pathophysiology 3rd Edition

Fundamentals of Applied Pathophysiology 3rd Edition

Fundamentals of Applied Pathophysiology 3rd Edition

Fundamentals of Applied Pathophysiology continues to be an accessible and comprehensive introductory text to pathophysiology, written specifically for nursing and healthcare students to assist in the understanding of human anatomy, and the complex disease patterns that affect normal physiology.

Thoroughly updated, and with full-colour illustrations throughout, this new edition incorporates additional learning features including reflective questions at the end of each chapter, investigation boxes, medication alerts, red flags to indicate essential information to be aware of when providing care, vital signs boxes relating to physiological measurements as well as inclusion of the National Early Warning Score.

With emphasis placed on a multidisciplinary approach, Fundamentals of Applied Pathophysiology highlights the importance of contemporary, safe, and effective practice in an environment in which the delivery of care is constantly evolving.

 

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Pathology of Heart Disease in the Fetus, Infant and Child

Pathology of Heart Disease in the Fetus, Infant and Child: Autopsy, Surgical and Molecular Pathology

Pathology of Heart Disease in the Fetus, Infant and Child

In recent years, there have been no books published on paediatric cardiac pathology despite enormous developments in genetics, a marked explosion of paediatric transplant programmes, surges in knowledge of fetal cardiac pathology and understanding of congenital heart disease, and the emergence of a flourishing cardiac imaging discipline. This book will be the first unified and comprehensive source of reference for childhood heart disease, covering the full field of paediatric cardiac pathology, in one volume. Comprising the twenty-five year experience of a single pathologist, the full spectrum of the pathology of heart disease, from the fetus to the adult, is uniquely presented here. Richly illustrated, with over 800 colour photographs, general and paediatric pathologists alike will be able to examine the microscopic features of the conditions described, with a specific focus on metabolic disease for practitioners worldwide.

 

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Surgical Management of Aortic Pathology

Surgical Management of Aortic Pathology: Current Fundamentals for the Clinical Management of Aortic Disease

Surgical Management of Aortic Pathology

This book follows the concept of perceiving the entire aorta as one functional organ assuming that all individual pathologies and local interventional procedures affect the up- and downstream segments with consequences for complications and disease progression. Thus any preventive or surgical strategy must recognize the aortic disease in its entirety.

The book intends to cover the full spectrum of aortic pathologies, mechanisms and functional interplay. The latest available diagnostic tools and options for surgical treatment are presented by the foremost experts in their field in state-of-the-art reviews. The reader is provided with the most current and comprehensive insight into all fundamental and clinical aspects of aortic disease. All chapters are carefully complemented with figures and illustrations.

 

 

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Pathology of Sinonasal Tumors and Tumor-Like Lesions

Pathology of Sinonasal Tumors and Tumor-Like Lesions

Pathology of Sinonasal Tumors and Tumor-Like Lesions

This book provides a comprehensive, up-to-date review of the field of diagnostic histopathology of sinonasal tumors and tumor-like lesions. It includes well-known and recently described structures, focusing on their epidemiological, clinical, radiological, and molecular features. It also discusses the latest surgical and medical treatment of these tumors. Primarily written for pathologists and pathology residents, the topics discussed make it a valuable resource for head and neck surgeons, radiologists, oncologists, and other clinical physicians.

Written by experts in the field, this book further our understanding of the pathology of sinonasal tumors.

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