Category: Oncology

This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.

This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics.

Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunoprofile of common tumors throughout all systems of human body. With numerous color figures and detailed flowcharts, it appeals to all pathologists be they young residents in training who want a brief introduction to this technique, or specialists in need of a reliable and comprehensive reference resource in tumors diagnostics.

Dr. Muin S.A. Tuffaha obtained a degree in general medicine with honors (MD) from the Medical Institute Kiev, UDSSR in 1986 before passing the German Board in Pathology. He continued as specialist in pathology at the Technical University of Dresden`s Institute of Pathology. Dr. Tuffaha was the deputy head of the Department of Head and Neck Pathology at the University of Hamburg. Since 2010, Dr. Tuffaha has been head at the Institute of Pathology, Carl-Thiem-Hospital a teaching hospital of the Medical Faculty Charité, Berlin, Germany. He received an honorary Professor from the Kiev Medical University of UAFM.

Professor Hans Guski is Professor of Pathology and the former Deputy Director of the Institute of Pathology of the Humboldt University of, where he worked for more than 40 years. During this time, he mentored about 70 doctoral candidates and published over 500 scientific articles and presented papers. He is co-author of several textbooks and monographs, including a monograph on immunohistochemical studies in tumors published in Russian by Dr. Tuffaha (Kiev 2013). Professor Guski has been an ordinary member of the Russian Academy of Natural Sciences since 1992 and is an honorary member of several international medical societies. He received an honorary doctorate from the State University of Saransk, Russia, in 1996, and has been a Guest Professor of the University of Havana, Cuba, since 2004.Professor Glen Kristiansen has been a professor of pathology and chair of the Institute of Pathology, University Bonn, Germany since 2011. From 2007 to 2011, he was a professor of molecular tumor pathology and head of the Immunohistochemistry Laboratory at the Institute of Surgical Pathology, University Zurich, Switzerland. He was also resident and later consultant and head of the Immunohistochemistry Laboratory at the Institute of Pathology, Charité, Berlin, Germany (1998-2007). In 2014, he broadened his skills at the Cedars-Sinai Hospital Medical Center, Los Angeles, USA. Professor Kristiansen has authored or co-authored more than 300 scientific publications and is an acclaimed speaker at international congresses.