Oncology ⋆ Page 27 of 46 ⋆ eMEDICAL BOOKS

Tumor Dormancy and Recurrence (Cancer Drug Discovery and Development) 1st ed. 2017 Edition

October 18, 2017

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This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions.

About the Author

Yuzhuo Wang, PhD, is Distinguished Scientist, Department of Experimental Therapeutics, BC Cancer Agency, Cancer Research Centre, Vancouver Prostate Centre, University of British Columbia, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.

Francesco Crea, PhD, is Post Doctoral Fellow, Department of Experimental Therapeutics, BC Cancer Agency, Cancer Research Centre, Vancouver Prostate Centre, University of British Columbia, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.

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Oncology

Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management (Current Clinical Urology) 2nd ed. 2018 Edition

October 18, 2017

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“The concept of active surveillance (AS) was developed by Klotz, with the aim of limiting the risk of overtreatment in patients with low-risk cancers, while providing timely radical treatment for those requiring it. Currently, this concept is supported by an increasing number of urologists. … This excellent overview dedicated to AS fills a lack in the literature. … this textbook can be recommended to all physicians involved in prostate cancer management.” (European Urology Today, Vol. 25 (2), March-May, 2013)

“This book summarizes the current worldwide experience with active surveillance for prostate cancer. … this book is appropriate for primary care physicians, surgeons, medical oncologists, radiation oncologists, pathologists, radiologists, psychiatrists, and psychologists. Furthermore, it would be valuable to the general audience and patients as it clearly describes the role and implications of active surveillance in the treatment of prostate cancer. … I strongly recommend this book to any clinician whose practice involves the treatment of patients with prostate cancer in any capacity.” (Sanjay Kasturi, Doody’s Book Reviews, October, 2012)

–This text refers to an out of print or unavailable edition of this title.

From the Back Cover

This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

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Dynamic Contrast-Enhanced MRI Atlas of Prostate Cancer 2009th Edition

October 18, 2017

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MRI Atlas of Prostate Cancer analyses high-resolution MRI scanning and dynamic contrast-enhanced (DCE) MRI. This combination improves the diagnosis and staging of prostate cancer and may soon replace PSA testing and digital rectal examination. The first two chapters focus on normal anatomy, anatomic variations, benign disease and intraprostatic tumors. The subsequent chapters on MRI of extracapsular disease create a useful atlas of pathologic anatomy. This is the first text of its kind to show color-coded DCE-MRI scans of prostate cancer and to correlate these imaging findings with tumor grading. The chapters on the post-treatment prostate clearly display the increasing incidence of post-therapy recurrences. This book is intended for internists, radiologists, radiotherapists, oncologists, urologists, family practitioners, and general surgeons. Ultrasound, MRI, and radiotherapy technicians will find it extremely useful as a reference guide.

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D-type Cyclins and Cancer (Current Cancer Research) 1st ed. 2018 Edition

October 18, 2017

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This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.

About the Author

Philip W. Hinds is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the Journal of Biological Chemistry, the Chinese Journal of Cancer, and Cancer Research to name a few.

Nelson E. Brown is currently Associate Professor at the University of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca. His current work focuses on the role of cyclin D1-associated kinase activity in senescence and tumorigenesis

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Oncology

Immunotherapy of Hepatocellular Carcinoma 1st ed. 2017 Edition

October 18, 2017

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In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials.

Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer.Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

About the Author

Professor Tim F. Greten has received his training in Gastroenterology, Hepatology and Medical Oncology. He has been treating patients with hepatocellular carcinoma (HCC) for many years has been leading a number of clinical trials. Apart from his clinical expertise Professor Greten has been interested in the immunological aspects of HCC for more than 20 years. He is conducting basic research studies, which he published in the very top scientific journals including Nature, and Cancer Cell and is also a pioneer in immunotherapy studies in HCC. He published a number of different clinical trials testing different immune based approaches in HCC. Based on this medical and basic science background is considered on the world leaders in tumor immunology and immunotherapy of HCC.

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Prostate Cancer: Diagnosis and Clinical Management 1st Edition

October 18, 2017

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Do you manage patients with prostate cancer?

Could you use an expert guide examining all possible management options?

Prostate Cancer: diagnosis and clinical management providesurologists and oncologists of all levels with up-to-date, evidence-based guidance to the diagnosis, treatment and clinical management of a disease which accounts for a quarter of all cancers affecting men.

Designed to be as practical and accessible as possible, leading experts discuss key issues in prostate cancer management and examine how to deliver best practice in the clinical care of their patients. Topics covered include:

What must be considered when counseling newly-diagnosed cancer patients
Radical surgery options for prostate cancer
Novel therapies for localized prostate cancer
How should metastatic prostate cancer be diagnostic and managed
What are the best methods of administering end of life care for the patient

Brought to you by a highly experienced editor team, and containing key points, management algorithms, practice tips and the latest AUA and EAU clinical guidelines, this is the ideal consultation tool for doctors both on the wards and in the office.

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DNA and Histone Methylation as Cancer Targets (Cancer Drug Discovery and Development) 1st ed. 2017 Edition

October 10, 2017

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This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

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Oncology

Detecting and Living with Breast Cancer For Dummies

October 5, 2017

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Your trusted, no-nonsense guide to detecting and managing breast cancer

From the breast health experts at the American Breast Cancer Foundation comes a sensitive and authoritative guide to the most common cancer in women: breast cancer. Covering everything from prevention to dealing with a diagnosis to coping with life after cancer, it serves as a trusted resource for anyone whose life has been touched by this dreaded disease.

Advancements in breast cancer prevention, detection, and treatment are being made every day, but it can be overwhelming and confusing knowing where to turn and who to trust. Detecting & Living with Breast Cancer For Dummies distills the information into one easy-to-follow guide, giving you quick, expert advice on everything you’ll face as you manage your breast health. From getting to know your treatment options to talking to loved ones about breast cancer—and everything in between—it does the legwork for you so you can take a deep breath and focus on your health.

Perform regular self-exams the right way
Cope with the many decisions that need to be made if you’re diagnosed
Ask the right questions about surgery, chemotherapy, radiation, and breast reconstruction
Decipher complicated pathology reports with confidence

Whether you’re at risk for breast cancer or have been diagnosed and want to know your options, Detecting & Living with Breast Cancer For Dummies empowers you to take your health into your own hands.

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Oncology

Radiation Oncology – A Question Based Review 2nd Edition Second Edition

October 5, 2017

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Test and solidify your knowledge of radiation oncology with Radiation Oncology: A Question-Based Review. This book’s Q&A format doesn’t merely encourage rote memorization, but expounds on most answers’ reasoning, background information, and clinical context to foster your complete understanding. Written by top experts, with each chapter authored by at least one resident and one faculty member, Radiation Oncology: A Question-Based Review is the perfect learning tool for students and physicians who are seeking to strengthen their long-term command of radiation oncology.

FEATURES

Covers all sites and cancer types currently treated with radiotherapy with an emphasis on treatment recommendations and the evidence behind them.
Detailed questions on the natural history, epidemiology, diagnosis, staging, and treatment-related side effects for each cancer type
Mnemonics and tables aid understanding and retention
Includes the latest data and most recent studies from the field to reflect current/standard radiation oncology practice
Updated appendix of normal tissue tolerance tables follows QUANTEC recommendations

Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to:

Complete content with enhanced navigation
A powerful search tool that pulls results from content in the book, your notes, and even the web
Cross-linked pages, references, and more for easy navigation
Highlighting tool for easier reference of key content throughout the text
Ability to take and share notes with friends and colleagues
Quick-reference tabbing to save your favorite content for future use
Interactive Q&A bank for self-testing

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Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies (Current Clinical Oncology)

October 5, 2017

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“In this detailed and up-to-date book, leaders in prostate cancer research review the current knowledge of genetic pathways and major molecular aberrations involved in prostate cancer as well as the treatment of the disease. … The figures and tables are clear and provide essential additional information. … the editors and authors have succeeded in clearly summarizing the most important recent advances in prostate cancer research, and the book will interest urologists, medical oncologists, and prostate cancer researchers.” (Joost L. Boormans, The New England Journal of Medicine, August, 2008)

From the Back Cover

Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. In, “Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies”, the authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer research, such as laparoscopic radical prostatectomy, and offers a critical evaluation and discussion of opportunities for development of novel therapies for prostate cancer. Clinical trials that have not been covered or evaluated in any other books currently available are also discussed. Invaluable to physicians and researchers, “Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies” provides a comprehensive translational resource as well as an important source of information for prostate cancer patients.

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