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Nail Disorders: A Comprehensive Approach 1st Edition

Nail Disorders: A Comprehensive Approach 1st Edition

Nail Disorders: A Comprehensive Approach 1st Edition

Nail disorders are a specialized group of disorders which are often neglected during post graduate teaching. This book aims to provide a comprehensive review covering the diagnostic and therapeutic aspects of nail disorders. It discusses the basics of nail unit, common conditions like infections, tumors and genetic diseases, diagnostic armamentarium involved in nail diseases like KOH mount, onychoscopy, imaging and surgical management of nail diseases which includes anesthesia of nail unit, nail biopsy and advanced nail procedures including video demonstration of such procedures. This book elaborates on nails in systemic diseases and briefly covers nail cosmetics and nail photography.

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Key Features

 

  • Comprehensively reviews nail disorders
  • Includes diagnosis, therapeutic and surgical aspect
  • Discusses Onychoscopy
  • Reviews the importance of nail photography

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Revision Spine Surgery: Pearls and Pitfalls

Revision Spine Surgery: Pearls and Pitfalls

Revision spine surgery requires a unique skill set different from performing a primary operation. Understanding when a simple revision is sufficient, when a more complex approach is needed, or when a non-surgical option should be considered is critical to good patient care and outcomes.

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In this first book to focus exclusively on the complex topic of revision spine surgery, world-renowned Dr. Alex Vaccaro and leading neuro and orthopaedic spine surgeons, navigate physicians through the initial evaluative process and the potential pitfalls and complications encountered in revision surgery.

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Textbook of Clinical Trials in Oncology: A Statistical Perspective

Textbook of Clinical Trials in Oncology: A Statistical Perspective

Textbook of Clinical Trials in Oncology: A Statistical Perspective

There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area.

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The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology.

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The Illustrated Dictionary of Toxicologic Pathology and Safety Science

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

The Illustrated Dictionary of Toxicologic Pathology and Safety Science

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists.

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With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings.

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Basic Clinical Radiobiology 5th Edition

Basic Clinical Radiobiology 5th Edition

Basic Clinical Radiobiology 5th Edition

Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

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This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.

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Prostate Cancer Imaging: An Engineering and Clinical Perspective

Prostate Cancer Imaging: An Engineering and Clinical Perspective

Prostate Cancer Imaging: An Engineering and Clinical Perspective

This book covers novel strategies and state of the art approaches for automated non-invasive systems for early prostate cancer diagnosis. Prostate cancer is the most frequently diagnosed malignancy after skin cancer and the second leading cause of cancer related male deaths in the USA after lung cancer. However, early detection of prostate cancer increases chances of patients’ survival. Generally, The CAD systems analyze the prostate images in three steps: (i) prostate segmentation; (ii) Prostate description or feature extraction; and (iii) classification of the prostate status.

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  • Explores all of the latest research and developments in state-of-the art imaging of the prostate from world class experts.
  • Contains a comprehensive overview of 2D/3D Shape Modeling for MRI data.
  • Presents a detailed examination of automated segmentation of the prostate in 3D imaging.
  • Examines Computer-Aided-Diagnosis through automated techniques.
  • There will be extensive references at the end of each chapter to enhance further study.

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Introduction to Forensic Chemistry 1st Edition

Introduction to Forensic Chemistry 1st Edition

Introduction to Forensic Chemistry 1st Edition

Forensic chemistryis a subdiscipline of forensic science, its principles guide the analyses performed in modern forensic laboratories. Forensic chemistry’s roots lie in medico-legal investigation, toxicology and microscopy and have since led the development of modern forensic analytic techniques and practices for use in a variety of applications.

Introduction to Forensic Chemistry is the perfect balance of testing methods and application. Unlike other competing books on the market, coverage is neither too simplistic, nor overly advanced making the book ideal for use in both undergraduate and graduate courses. The book introduces chemical tests, spectroscopy, advanced spectroscopy, and chromatography to students. The second half of the book addresses applications and methods to analyze and interpret controlled substances, trace evidence, questioned documents, firearms, explosives, environmental contaminants, toxins, and other topics. The book looks at innovations in the field over time including the latest development of new discernible chemical reactions, instrumental tools, methods, and more.

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Regulatory Toxicology, Third Edition

Regulatory Toxicology, Third Edition

Regulatory Toxicology, Third Edition

This practical book provides toxicologists with essential information on the regulations that govern their jobs and products. Regulatory Toxicology, Third Edition is an up-to-date guide to required safety assessment for the entire range of man-made marketed products. Individual chapters written by experts with extensive experience in the field address requirements not only for human pharmaceuticals and medical devices (for which there are available guidances), but for the full range of man-made products. New in this edition are three chapters addressing Safety Data Sheet Preparation, Regulatory Requirements for GMOs, and Regulatory Requirements for Tobacco and Marijuana. The major administrative divisions for regulatory agencies and their main responsibilities are also detailed, as are the basic filing documents the agencies require.

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Coverage includes food additives, dietary supplements, cosmetics, over-the-counter drugs, personal care and consumer products, agriculture and GMO products, industrial chemicals, air and drinking water regulations and the special cases of California’s Proposition 65, requirements for safety data sheets, and oversight regulations. Both US and international requirements are clearly presented and referenced. In one volume, those who have regulatory responsibility in companies, lawyers, educators, and those selling these materials in the marketplace can learn about regulatory requirements and how to meet them.

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Handbook of Forensic Toxicology for Medical Examiners 2nd Edition

Handbook of Forensic Toxicology for Medical Examiners 2nd Edition

Handbook of Forensic Toxicology for Medical Examiners 2nd Edition

Forensic professionals, particularly medical examiners―often working through heavy caseloads―require quick and easy access to reliable sources of information to help interpret toxicology results. While several in-depth resources are available, they are often large, cumbersome, and contain more information than is often needed.

The Handbook of Forensic Toxicology for Medical Examiners is a concise handbook referencing the most common toxic substances and their reported non-toxic, toxic, and lethal concentrations, making it an ideal text for quick reference in the lab or autopsy room.

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Features of the Second Edition:

    • Explains the principles of postmortem toxicology and the factors which must be considered
    • Provides tables of toxicologic data for over 200 commonly encountered substances, including drugs of abuse, poisons, prescription drugs, and over-the-counter medications
    • Includes discussion and description of the novel psychoactive drugs―including synthetic opioids, cannabinoids, stimulants and hallucinogens
    • Supplemental appendices provide additional information regarding specimen types and selection, testing methodologies, normal laboratory values, and conversion charts

The busy forensic professional needs a concise handbook that provides critical information quickly and accurately. This heavily referenced text offers an easy-to-use format allowing for rapid access for both routine daily use and preparation for courtroom testimony.

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Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk.

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Toxicologic Pathology: Nonclinical Safety AssessmentSecond Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions.

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