Soft Tissue Augmentation: Principles and Practice

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Stem Cell Aging: Mechanisms, Consequences, Rejuvenation 1st ed

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Desquamative gingivitis – A clinico-pathologic study: Erythematous Gingiva, Incisional biopsy, Histopathology of Muco-cutaneous disorders

Gingival Desquamation is a clinical manifestation in many inflammatory and immunological disorders. Although, Oral lichen planus, pemphigus vulgaris and mucous membrane pemphigoid accounts for majority of cases of gingival desquamation, but rare case such as Linear Ig A disease, Plasma cell gingivitis, tuberculosis and chronic ulcerative stomatitis should also be taken into consideration. Gingival Desquamation may present as the only manifestation in some cases, while, it may be associated with other oral and extra oral manifestations, like wickham’s striae in lichen planus, Nikolsky’s sign in pemphigus vulgaris, Ocular involvement in mucous membrane pemphigoid which help in diagnosis. In such cases, the patient should be referred to the concerned specialists for extra oral lesions. Cases where gingival desquamation is the only presenting feature,should be carefully taken care of, as they can mimic plaque induced gingivitis.Thus, familiarisation of various clinical presentation of gingival desquamation is essential for early diagnosis and treatment planning.This book, deals in detail the various causes for gingival desquamation, along with the histopathological features.

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Pathogenesis and Treatment in IgA Nephropathy: An International Comparison 1st ed

This book discusses the latest findings on the pathogenesis and treatment of IgA nephropathy. It particularly focuses on recently recognized initiation and progression factors and the varying treatment strategies in different regions, such as Asia, Europe, and the United States. More than 40 years have passed since Dr. Jean Berger first described primary IgA nephropathy (“Nephropathy with mesangial IgA-IgG deposits”) as a new disease entity.

Immunohistopathologically, IgA nephropathy is characterized by the granular deposition of IgA (IgA1) and C3 in the glomerular mesangial areas with mesangial cell proliferation and the expansion of mesangial matrices. It is clear that IgA nephropathy is one of the most common types of chronic glomerulonephritis in the world. This disease may lead to end-stage kidney disease, with its enormous economic impact on healthcare everywhere. Efforts by many investigators around the world have gradually clarified various aspects of the pathogenesis and treatment of IgA nephropathy. However, there are many controversial strategies for the treatment of patients with IgA nephropathy throughout the world, as there are several limitations for treatment in each country. This volume provides nephrologists everywhere with an overview and comparison of both global and regional findings in basic and clinical fields in IgA nephropathy. It covers genetic variation, aberrant IgA1 production, and classification etiology, guidelines, and treatment goals, with all chapters written by top international researchers.

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Inguinal Hernia Surgery (Updates in Surgery) 1st ed

This book, which describes in detail the most common procedures employed in inguinal hernia surgery, is exceptional in reflecting fully the most recent advances, as well as the most established techniques, in knowledge and practice. The role of recently developed and emerging technologies, including robotics, minimally invasive surgery, and biological meshes, is clearly explained, highlighting useful tips and tricks. The descriptions of traditional procedures, such as the Lichtenstein repair, are brought fully up to date and take into account the novel perceptions that professionals have of them, for example regarding the important role of nurses. The reader will also find guidance on established and new treatments for specific pain conditions, including postoperative chronic pain, the pubic inguinal pain syndrome, and obscure groin pain in women. The need for such an update on inguinal hernia surgery became clear at the 1st World Conference on Abdominal Wall Hernia Surgery, which highlighted the huge differences in the approaches adopted by scientists around the world and was chaired by the editor of this book. Inguinal Hernia Surgery will be a useful tool for all health care practitioners involved in hernia surgery.

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Platelets, Thrombosis and the Vessel Wall (Advances in Vascular Biology) 1st Edition

This book discusses key aspects of platelet function in the regulation of hemostasis and thrombosis. It covers topics ranging from the platelet cytoskeleton to the antiphospholipid-antibody syndrome. Among the many highlights of the book is the section on von Willebrand’s disease, a group of quantitative and qualitative abnormalities of von Willebrand factor. These abnormalities are the most common causes of inherited bleeding disorders, with a prevalence of up to 1 percent of the population. The defect in primary hemostasis results from a failure of platelet adhesion at the site of vascular damage. New ways of classifying von Willebrand’s disease according to its pathophysiologic characteristics are discussed by Sadler. Lopez and colleagues review the glycoprotein Ib/IX/V complex, a group of proteins on the platelet surface that make it possible for the platelet to bind to matrix-bound von Willebrand factor. The authors point out that the Ib/IX/V complex forms a receptor with unique functions — platelet adhesion and activation — and they discuss how the binding of von Willebrand factor to the complex initiates platelet activation.

Du lucidly describes the dialogue between extracellular and intracellular compartments of the platelet. Some signaling pathways in the platelet are initiated with the binding of an agonist to a platelet membrane receptor; this causes the receptor to increase its affinity and thereby acquire the ability to respond to ligands such as fibrinogen and von Willebrand factor. Other signaling pathways are initiated after the ligation and clustering of integrins (transmembrane proteins that allow the attachment of cells to the extracellular matrix). The binding of ligands to receptors for platelet-derived growth factor or the thrombin receptor results in platelet spreading, secretion from intracellular granules, the availability of platelet membrane phospholipoprotein for coagulation, and clot retraction. Fox and Meyer, in discussing the platelet cytoskeleton, emphasize the similarity of cytoskeletal reorganizations in platelets to those in other cells, and Campbell and associates describe the background and current status of phosphoinositide-derived second-messenger molecules in platelet activation.

The important platelet membrane glycoprotein CD36 is discussed by Thorne and colleagues. Discrete functions of CD36 have been elucidated in lipid metabolism, fatty-acid transport, cell adhesion, angiogenesis, inflammation, and activation of transforming growth factor (beta). A deficiency of CD36 has been associated with hereditary hypertrophic cardiomyopathy.

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Handbook on Clinical Approach to Respiratory Medicine 1st Edition

This book is a concise guide to respiratory medicine for clinicians. Beginning with an overview of anatomy of the respiratory system, the following section discusses history taking, symptoms and examination, placing emphasis on the importance of accuracy in history taking for provisional diagnosis. The next chapters describe common investigations in respiratory evaluation, using case studies to enhance learning. The final part of this useful handbook covers the management of pulmonary emergencies including acute exacerbation of bronchial asthma and of chronic obstructive pulmonary disease, tension pneumothorax, hemoptysis, and respiratory failure. The book is further enhanced by clinical images and diagrams. Key points * Concise guide to respiratory medicine for clinicians * Emphasises importance of accurate history taking for provisional diagnosis * Covers common investigations using case studies to enhance learning * Includes discussion on management of pulmonary emergencies

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Recent Advances on the Modular Organization of the Cortex

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Socio-Ecological Dimensions of Infectious Diseases in Southeast Asia

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Signal Processing in Neuroscience 1st ed

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