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Achondroplasia and Other FGFR3-related Short Limbed Dysplasia: Molecular Heterogeneity and Therapeutic Approaches

Achondroplasia and Other FGFR3-related Short Limbed Dysplasia: Molecular Heterogeneity and Therapeutic Approaches

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This book discusses achondroplasia and other FGFR3-related short limb dysplasias, their molecular heterogeneity, and therapeutic approaches. Achondroplasia is dominantly inherited and one of the most common genetic causes of non-lethal short limb skeletal dysplasia due to mutations in FGFR3. Other FGFR3-related short limb dysplasias include hypochondroplasia, thanatophoric dysplasia (type I and type II), and severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN). Suppression of proliferation and differentiation of chondrocytes in the growth plates (as a result of a specific gain-of-function mutation in the transmembrane domain of FGFR3) is the underlying mechanism. Most of the clinical and radiological features of achondroplasia are either direct or indirect consequences of this suppression of endochondral bone growth due to overexpression of FGFR3 signaling. Downstream C-type natriuretic peptide (CNP) antagonism to FGFR3 activity can be used as a potential therapeutic strategy in achondroplasia. A new era has been entered with the phase 2 trial of CNP analogue BMN 111 showing promising results in children with achondroplasia. This has demonstrated that curing patients with skeletal disorders is not a dream anymore

Urodynamics for Urogynecologists: A Pocket Guide for Clinical Practice 1st ed. 2018 Edition

Urodynamics for Urogynecologists: A Pocket Guide for Clinical Practice 1st ed. 2018 Edition

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This book offers gynecologists and urogynecologists a pocket guide to urodynamic testing in women with lower urinary tract symptoms. In female urology, the main indications for urodynamics are urinary incontinence, pelvic organ prolapse, urgency-frequency syndrome (also known as overactive bladder), emptying disorders and painful bladder. By collecting quantitative measurements while reproducing the patient’s voiding symptoms where appropriate and possible, urodynamics helps to identify the cause of symptoms, supports management and facilitates prognoses. However, despite the undeniable advantages, the role of urodynamics in female urology is hotly debated. The book starts by describing the physiological background and methodological considerations for urodynamic best practice in the preclinical setting. It then explains how to perform urodynamics correctly – so-called “good urodynamic practice” – to increase the readers’ confidence and ability to perform and interpret urodynamic investigations. Lastly, it reviews the advantages and disadvantages of urodynamic testing in each of the key clinical female urology conditions. A separate chapter focuses on the peculiarities of diagnosis and management for female patients with neurogenic bladder. This guide offers a valuable tool for gynecologists, urologists and urogynecologists, as well as a ready source of information for all physicians involved in diagnosing and treating lower urinary tract disorders in women.

Extra-Coronal Restorations: Concepts and Clinical Application (BDJ Clinician’s Guides) 2nd ed. 2019 Edition

Extra-Coronal Restorations: Concepts and Clinical Application (BDJ Clinician’s Guides) 2nd ed. 2019 Edition

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This book is a state of the art clinical guide to contemporary materials and techniques for the restoration of individual teeth and implants. It fully reflects the important developments in the field over the past 15 years, including in particular the shift away from wholesale use of crowns towards adhesive dentistry and less invasive extra-coronal restorations. The book opens by considering the principles and evidence base relating to the longevity of restorations of teeth and implants. Importantly, it explains how to ensure “a healthy start” and manage future risks. Material choice and aesthetic issues are then discussed, before all aspects of the planning and provision of extra-coronal restorations are examined in depth. The coverage also includes the adaptation of crowns to existing partial dentures. In line with modern dental education, each chapter begins with clinically relevant learning objectives, and helpful clinical tips are highlighted. The book will be of value for senior dental undergraduates, postgraduates, and practicing dentists and its scientific content will be of interest to dental academics.

Lung Transplantation: Evolving Knowledge and New Horizons 1st ed. 2018 Edition

Lung Transplantation: Evolving Knowledge and New Horizons 1st ed. 2018 Edition

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This book details all aspects of lung transplantation and equips the general pulmonologist/physician with the necessary tools and knowledge to assist patients with the preparation for and care post lung transplantation. Written by global experts, chapters  present general principles and history; indications and eligibility for lung transplantation, including screening for COPD, cystic fibrosis, scleroderma, Idiopathic pulmonary fibrosis (IPF) and idiopathic pulmonary arterial hypertension; approach to and complications of lung transplantation, such as prognostic markers, radiological approach, and immunology and rejection; and medical and surgical guidelines for lung transplantation. The goal of lung transplantation is to increase survival and to provide a greater quality of life for patients with untreatable end-stage lung disease and this book serves to best prepare clinicians in achieving that goal. Lung Transplantation: Evolving knowledge and New horizons offers valuable insights into this modality and is an authoritative resource for multidisciplinary services that include experts in pulmonary diseases, critical care, cardiology, thoracic surgery, infection diseases, internal medicine,  radiology , immunology, nephrology, rehabilitation, psychology /psychiatry, nurses, social workers and  nutritionists.

Essential Clinical Skills in Pediatrics: A Practical Guide to History Taking and Clinical Examination 1st ed. 2018 Edition

Essential Clinical Skills in Pediatrics: A Practical Guide to History Taking and Clinical Examination 1st ed. 2018 Edition

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This book is a concise learning guide dedicated to the full scope of pediatric history-taking and clinical examination, for use in OSCEs as well as clinical life.

It guides the reader simply and methodically through what to ask when taking a history, and how to perform a comprehensive physical examination. The book contains more than 30 “History Stations” covering the most common pediatric cases, as well as 10 “Examination Stations” covering examinations of the different body system. It provides students and resident doctors worldwide with the necessary core information for pediatric history-taking and clinical examination, all in a brief and interesting format.

The book adopts a reader-friendly format through a lecture-note style and the use of Key Points, Clinical Tips, Notes, Tables, and Boxes listing the most important features. It is also richly illustrated, demonstrating the correct way to perform clinical examinations.

Written “by a resident, for residents and medical students,” this book has been revised, foreworded, and peer-reviewed by fourteen prominent authorities in the field of Pediatrics from various parts of the world (including the United States, United Kingdom, Australia, Italy, Canada, and India), and from different universities (Illinois, Pennsylvania, Washington, Oxford, Edinburgh, Keele, Melbourne, Toronto, Parma, and Florence Universities). These experts recommend this book for medical students, pediatric residents, and pediatric practitioners, as well as pediatricians.

Global Bariatric Surgery: The Art of Weight Loss Across the Borders 1st ed. 2018 Edition

Global Bariatric Surgery: The Art of Weight Loss Across the Borders 1st ed. 2018 Edition

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This text captures the global standards of bariatric surgery practice at a time of change, excitement, and lots of controversy. The text sheds the light on best practices globally by providing a reliable reference to guide the practicing physician anywhere in the world, and from whatever specialty (surgeon, gastroenterologist or endoscopist) to navigate through the many current options of therapy in this rapidly changing field. The text provides high definition illustrations of these techniques to go with the didactic chapters written by the thought leaders in the field. In addition to the technical part, an important part of the book focuses on quality and outcome measures. The rapid growth and innovations impose the need for strict guidelines and quality control. Thought leaders who created the concept of “Centers of Excellence” shed light on outcome measures and different ways to monitor quality. This will appeal to administrators and different ancillary service providers. The medical section plays a major role as combination therapy seems to be the future. An entire section is dedicated to medical weight management with discussions of the dietary and psychological component of care. The text also provides a dedicated discussion of the metabolic aspect of bariatric surgery, cosmetic surgery and issues of training future surgeons. Thease features differentiate the book from others that only discuss the surgical component, and will broaden the level of interest to all who are involved in the management of this complex disease.

Arthroplasty for the Treatment of Fractures in the Older Patient: Indications and Current Techniques 1st ed. 2018 Edition

Arthroplasty for the Treatment of Fractures in the Older Patient: Indications and Current Techniques 1st ed. 2018 Edition

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Focusing exclusively on the older patient with poor bone quality, this unique book presents the indications, contraindications and common techniques – as well as the risks, benefits and outcomes – for utilizing arthroplasty for the treatment of fractures in this population, sensibly divided into four thematic sections. The incidence and burden of fragility fractures is presented in part one, with considerations of the influences of osteoporosis on both treatment and healing. The subsequent three sections cover upper extremity fractures, lower extremity fractures, and peri-articular nonunions, respectively. However, far from providing a simple “how-to” for the techniques discussed, the relevant current literature is presented as well as the common techniques employed in fracture management, allowing the reader to select the best approach for the specific patient presentation. In addition, chapters are included here that cover degenerative joint conditions not typically treated with total joint replacement.

The treatment of fragility fractures is constantly evolving, and the aging population is consistently expanding, creating a strong need for clinicians who have experience with and exposure to the use of arthroplasty techniques as an option in their successful treatment. Written and edited by leaders in the field, Arthroplasty for the Treatment of Fractures in the Older Patient is an invaluable resource for orthopedic surgeons, residents and support staff who see and treat these increasingly common injuries.

Diffuse Gastric Cancer 1st ed. 2018 Edition

Diffuse Gastric Cancer 1st ed. 2018 Edition

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We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible.

Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.

Extreme Sports, Extreme Bodies: Gender, Identities and Bodies in Motion

Extreme Sports, Extreme Bodies: Gender, Identities and Bodies in Motion

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This book investigates extreme sports, defined as sports in which athletes challenge and transgress societal perceptions of what is humanly possible to achieve, in terms of physical training and bodily development/performance. Situated within a growing body of literature analysing the impact of new training trends on an individual’s body, identity, lifestyle and perception of his/her social surroundings, Extreme Sports, Extreme Bodies focuses on the gendered and embodied experiences of bodybuilding, Ironman triathlon, and mixed martial arts.

Through their ethnographic analysis, Andreasson and Johansson present a unique and updated account of the increasing phenomenon of extreme sports and extreme bodies in contemporary Western society, grounded in the sociology of sport, body studies and embodiment literature.

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