Bone Health: A Reflection of the Social Mosaic 1st ed
This multidisciplinary book addresses three lines of evidence (medieval, contemporary, and epigenetic) regarding the effect of human socio-economic status on bone health. It provides an overview of the extent to which human social background affects adult bone quality and quantity, and makes recommendations for future skeletal biology research into lifestyle-related musculoskeletal disorders.
The book is divided into three major parts, the first of which discusses bone and dental health in medieval human skeletal remains from distinct socio-economic status groups. In turn, Part 2 reviews bone health in contemporary human populations with a range of social backgrounds; in addition, a conceptual model proposing a social gradient of osteoporosis and fracture risk related to biological mechanisms and cumulative stressors throughout the human lifecycle is presented. Lastly, Part 3 highlights the role of epigenetics in socially patterned risk factors for skeletal disorders, and discusses how epigenetic mechanisms transduce the psychosocial environment and increase the risk of developing conditions such as osteoporosis.
Overall, the book highlights the importance of considering the social-biological nexus in future skeletal biology research and future treatment of bone disease. Increased awareness of this nexus can potentially improve individual and population-level bone health interventions, reducing the social inequities observed in fracture risk.
Given its scope, the book offers a valuable resource for researchers, academics, and students in the fields of medicine, epidemiology, the health sciences, biological anthropology, human anatomy and adaptation, developmental studies of human societies, human biology, and any field concerning musculoskeletal disorders and health. It will also benefit clinical practitioners evaluating osteoporosis, osteopenia, fracture risk, bone quality and quantity.
Textbook of Neuroanesthesia and Neurocritical Care: Volume II – Neurocritical Care
This two-volume book offers a comprehensive guide to anesthetic management and critical care management in neurosurgical and neurological patients. This second volume focuses on neurocritical care.
The book begins with basic information on the principles of neurocritical care. Management of various neurological problems such as myasthenia gravis, Guillain-Barré syndrome, epilepsy, stroke and many more are discussed in detail. Subsequent sections address nursing care, physiotherapy and psychological care, issues related to brain death and organ donation, and common complications observed in neurological patients during their ICS stays. Each complication is discussed in detail, guiding readers in their clinical practice. In turn, the book’s closing chapters cover e.g. the role of hypothermia and evidence-based practice.
The book offers a valuable resource for all residents, fellows and trainees in the fields of neurointensive care and critical care; it will also benefit intensivists and neurocritical care experts.
Oropharyngeal Dysphagia: Videoendoscopy-Guided Work-up and Management
This book is a practical guide that will assist ENT doctors in interpreting swallowing videoendoscopies correctly and in choosing complementary instrumental examinations to consolidate or exclude their provisional diagnosis. In addition, it provides speech-language pathologists with valuable hints on how to treat patients with oropharyngeal dysphagia more efficiently. The book is constructed around videoendoscopic features. The relevance of these features to diagnosis and treatment is carefully described with the aid of numerous high-quality illustrations. Beyond this, the relationship of videoendoscopy to two further instrumental examinations – videofluorography and pharyngeal manometry– and to the three treatment paths of texture adaptation, rehabilitation, and surgery is explained. The use of pictograms in this context helps to elucidate the connections, creating in the reader’s mind “clusters of behaviors” of benefit in clinical practice. The book also includes a short summary on swallowing anatomy and physiology, a chapter on medications inducing dysphagia, key take-home messages, and suggestions for further reading.
Cardiovascular Regenerative Medicine: Tissue Engineering and Clinical Applications
This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment.
The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine.
Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.
Training for Change: Transforming Systems to be Trauma-Informed, Culturally Responsive, and Neuroscientifically Focused
This book offers an integrated training and coaching system to facilitate change in systems that serve youth (education, healthcare, and juvenile justice). The integrated training and coaching system combines brain development, cultural responsivity, and trauma-informed practices. The book provides a comprehensive overview of the neurobiology of fear, brain development, trauma, substance use, and mental health, structural bias and environmental factors that pose a threat to healthy brain development. The book employs practical applications/recommendations and case examples that help solidify understanding of key concepts. Each chapter begins with a set of objectives and interactive exercises that builds on the next, thoughtfully challenging the reader (and giving specific, practical ways for the reader) to apply the information presented with the goal of “change”. The text is written from the perspective of a trauma-informed addiction psychiatrist who has effectively facilitated systems change.
Topics featured in this book include:
- Common threats to healthy brain development.
- The neurobiology of trauma.
- Applying trauma-informed practices and approaches.
- Cannabis and its impact on the brain.
- Labeling theory and implicit bias.
- Exploring the connection between fear and trauma.
- Rehabilitation versus habilitation.
- Managing stress through mindfulness.
Training for Change will be of interest to graduate and advanced undergraduate students and researchers in the fields of cognitive psychology, criminology, public health, and child and adolescent development as well as parents, teachers, judges, attorneys, preventative medicine and pediatric providers.
Using Central Neuromodulators and Psychological Therapies to Manage Patients with Disorders of Gut-Brain Interaction: A Clinical Guide
This guide provides a concise overview of central neuromodulators and psychological therapies, and their use in managing patients with disorders of gut-brain interaction. The text demonstrates how central neuromodulators can help disordered gut function and reviews choices of drugs for different disorders, along with dosages and recommendations on their use. The book also outlines the use of cognitive behavioral therapy and exposure therapy in treating these patients, and presents a tutorial on how internal medicine physicians should approach the use of psychiatric medications.
Written by experts in the field, Using Central Neuromodulators and Psychological Therapies to Manage Patients with Disorders of Gut-Brain Interaction: A Clinical Guide is a valuable resource for clinicians and practitioners on how to treat and manage patients afflicted with disorders of gut-brain interaction.
Maternal Drug Use and Infant Congenital Malformations 1st ed
This book is the combination of the literature on maternal drug use and birth defects with a set of new data on most types of drugs.
In this book, for each group of drugs the relevant scientific literature on drug teratogenicity is presented, with consideration of possible sources of error and also what the findings may mean from a practical point of view. The book also adds data from the Swedish health registers for 1996-2013 based on more than 1.7 million early-pregnancy midwife interviews.
Maternal Drug Use and Infant Congenital Malformations will find an engaged audience among people working within the field, and will be of interest to healthcare providers, especially obstetricians and other clinicians who treat women of childbearing age.
Targeted Therapies for Lung Cancer (Current Cancer Research)
This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
Neurorheumatology: A Comprehenisve Guide to Immune Mediated Disorders of the Nervous System
This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune mediated disorders of the nervous system. Following this are 25 chapters devoted to individual clinical conditions. To conclude, the final section explains what is known about the mechanisms of immunomodulatory treatments and practical points about monitoring patients on these treatments.
Neurorheumatology: A Comprehensive Guide to Immune Mediated Disorders of the Nervous System bridges the gaps among different branches of medicine and is an indispensable resource for rheumatologists and neurologists looking to develop a firm understanding of these dynamic disorders
Muscle Injury in the Athlete: The Italian Consensus Conference Guidelines
This volume provides a cutting-edge analysis concerning the biology and aetiology, classification, clinical assessment and conservative treatment of lower limb muscle injuries in athletes. Muscle injuries are the most common trauma both in team and individual sports and are responsible for most of the time lost both in training and in competition: in professional football (soccer), they account for 30% and in track and field for 48% of all injuries recorded. Despite the considerable interest in this topic among clinicians and researchers, there is still no consensus regarding the etiopathogenesis, classification, clinical examination and treatment of muscle lesions.
Based on the first Italian Consensus Conference on guidelines for the conservative treatment of lower limb muscle injuries in athletes, which was held in April 2017 at Humanitas Clinic Institute in Milan, Italy under the auspices of the Italian Society of Arthroscopy, this comprehensive book addresses the main issues concerning muscle injuries, from biology and pathobiology to clinical evaluation and different treatment option, including the most frequently used physio-kinesitherapy therapies. It also presents a consensus classification of muscle injuries closely linked to prognostic factors. Written by international experts with diverse medical backgrounds, this book offers comprehensive practical guidance for orthopedic surgeons, sports physicians, athletic trainers, physiotherapists, sports science students, and physiatrists.