Cleft Lip and Palate Treatment: A Comprehensive Guide 1st ed. 2018 Edition

The aim of this book is to discuss cleft lip and palate deformities in a comprehensive way, presenting it from the basics to the most clinically and surgically relevant issues. First, the basic concepts of embryology and pathogenesis of the facial deformities will be discussed. Special attention will be paid to the genetics underlying this condition. Following that, basic principles of surgical treatment through the most recent advances in the field will be presented, along with most important evidences from the literature and the personal experience of the editors and authors.

Cleft Lip and Palate Treatment presents the state of the art and advances in the field and is intended to serve as a comprehensive guide for a broad audience. All the specialties involved in the comprehensive care of these craniofacial deformities will be presented in this book.


Rhinoplasty: An Anatomical and Clinical Atlas 1st ed. 2018 Edition

In this atlas, sequential anatomical dissections are presented which show each component of the nose in unprecedented meticulous detail.  Anatomical photographs are often paired with anatomical drawings and even intraoperative clinical photographs to illustrate each part of the nose.

Rhinoplasty: An Anatomical and Clinical Atlas, provides an in-depth understanding of nasal anatomy and a wide variety of operative techniques. In rhinoplasty surgery, the surgeon must understand the tight linkage between surface aesthetics, underlying anatomy, and selection of operative techniques. The underlying anatomy is only revealed to a limited degree at the time of surgery and the surgeon must then adapt the operative plan to fit the actual anatomy observed in the operating room to achieve the patient’s desired aesthetic result. Ultimately, the goal  of this atlas is to allow the surgeon to see the operative techniques in both cadavers and clinical cases which represents the best possible learning approach.


Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs: Cell Signaling Pathways and microRNAs in Cancer Biology 1st ed. 2018 Edition

Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics.
This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

Neuroimaging Diagnosis for Alzheimer’s Disease and Other Dementias 1st ed.

This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer’s disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan. The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields.


Male Infertility: A Clinical Approach 1st ed

The book aims to bring into focus the current understanding of male reproduction and the pathological basis of failure to reproduce in men. Infertility in men is a common disorder. However, attempts at scientific study of male infertility are of very recent origin. Many questions about the physiology and pathophysiology of male reproduction are still not clear. The chapters are written by authorities in the field with great clinical experience. The primary focus would be on clinical perspective; however emphasis would also be placed on basic research and molecular biology.


Cancer Drug Discovery: Science and History 1st ed

The reader will discover a comprehensive and multifaceted overview of the history of the development of anticancer drugs deeply influenced by the cell concept of cancer and future directions for the development of new anticancer drugs. First, this book documents the scientific progress in biological science over the last 70 years and the influence this progress had in cancer research. Summaries and charts of important discoveries complete this overview. Furthermore, this book outlines the process of anticancer drug development with a focus on the characteristic drug groups of each era, related to advancements of chemistry and biological sciences. This book also provides brief mechanism of action of drugs, illustrated by comprehensive timelines and conceptual cartoons. This book finally sums up the limitations of the current anticancer drug development and seeks new directions for anticancer drug discovery, considering under the systemic view of cancer.


From Protein Structure to Function with Bioinformatics 2nd ed

This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins.

The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initiomethods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously.

This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.


Laparoscopic Donor Nephrectomy: A Step-by-Step Guide 1st ed

This book explains the development of various laparoscopic donor nephrectomy (LDN) techniques, which can be performed via the retroperitoneal or the transperitoneal approach. It provides a step-by-step explanation of LDN, including details of intricacies such as port positioning, dissection steps, securing the hilum and retrieval. It also reviews new techniques like robotic donor nephrectomy and single-port donor nephrectomy. Lastly, it explores the non-technical but equally important issues of donor work-up and legal and social aspects.

LDN is a unique surgical procedure in which the surgeon operates on an individual who is not a patient but someone donating out of altruistic motives, and it has to be “zero error” for the safety of the graft, donor and the recipient. This handbook is a valuable resource for urologists, general and transplant surgeons as well as anesthesiologists and medical social workers working in the field.


Drug Design: Principles and Applications 1st ed. 2017 Edition

This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other diseases.It is intended for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in bioinformatics, computational biology, medicine, pharmaceutics and other related fields.


Respiratory Endoscopy 1st ed. 2017 Edition

This book provides a detailed overview of the latest innovations in respiratory endoscopy, from both diagnostic and therapeutic perspectives; each chapter focuses on one disease and the techniques for early diagnosis as well as treatment. It comprehensively covers treatment and procedures, including simultaneous X-ray fluoroscopy and its use during bronchoscopic procedures. This fast-developing technology is essential for the medical management of non-malignant and malignant diseases of the chest, especially lung cancer. Respiratory Endoscopy describes the cooperation between all the members of the healthcare team, and as such is a valuable resource not only for medical staff, but also for radiological technicians and nursing staff who contribute significantly in the care of the patients undergoing these invasive procedures. By promoting teamwork and providing practical know-how, it will improve the success and safety of respiratory endoscopy procedures.


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