Noninferiority Testing in Clinical Trials: Issues and Challenges (Chapman & Hall/CRC Biostatistics Series) 1st Edition

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Take Your NI Trial to the Next Level

Reflecting the vast research on noninferiority (NI) designs from the past 15 years, Noninferiority Testing in Clinical Trials: Issues and Challenges explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a clinical trial. Requiring no prior knowledge of NI testing, the book is easily accessible to both statisticians and nonstatisticians involved in drug development.

With over 20 years of experience in this area, the author introduces the basic elements of the NI trials one at a time in a logical order. He discusses issues with estimating the effect size based on historical placebo control trials of the active control. The book covers fundamental concepts related to NI trials, such as assay sensitivity, constancy assumption, discounting, and preservation. It also describes patient populations, three-arm trials, and the equivalence of three or more groups.

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The Practice of Internal Dosimetry in Nuclear Medicine (Series in Medical Physics and Biomedical Engineering) 1st Edition

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Written by one of the world’s leading experts in the field of nuclear medicine dosimetry, this text describes in detail the use of internal dose calculations in the practice of nuclear medicine. While radiation therapy with external sources of radiation always employs calculations of dose to optimize therapy for each patient, this is not routinely conducted in nuclear medicine therapy. As the trend towards an increasing role of dosimetry in therapy planning increases, this book reviews the available methods and technologies available to make this a more common practice.

The book begins by covering the mathematical fundamentals of internal dose calculations, and uses sample calculations to demonstrate key principles. The book then moves forward to describe anthropomorphic models, dosimetric models, and types and uses of diagnostic and therapeutic radiopharmaceuticals. The depth of coverage makes it useful reference and guide for researchers performing dose calculations and for physicians considering incorporating dose calculations into the treatment of their cancer patients.

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Anesthesia and Perioperative Care for Organ Transplantation 1st ed. 2017 Edition

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This comprehensive textbook, covering all aspects of the perioperative management of patients undergoing organ transplantation, serves as the standard reference for clinicians who care for transplant patients on a day-to-day basis as well as those who encounter organ transplantation only occasionally in their clinical practice. Anesthesia and Perioperative Care for Organ Transplantation covers transplantation of the heart, lung, liver, pancreas, and kidney, as well as multivisceral and composite tissue graft transplantations. For each kind of transplantation, the full spectrum of perioperative considerations is addressed: preoperative preparation, intraoperative anesthesia management, surgical techniques, and postoperative care. Each chapter contains evidence-based recommendations, relevant society guidelines, management algorithms, and institutional protocols as tables, flow diagrams, and figures. Photographs demonstrating surgical techniques, anesthesia procedures, and perfusion management are included. Anesthesia and Perioperative Care for Organ Transplantation is for anesthesiologists and critical care physicians; transplantation surgeons; nurse anesthetists; ICU nurses; and trainees.​​

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All Things Nursing 1st Edition

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All Things Nursing provides quick access to essential information in all areas of nursing. Coverage includes assessment techniques and tips, skills, pain management, drugs, infection control, ECGs, laboratory tests, and disease profiles. The book also provides timely information on legal aspects of nursing, such as liability, organ donation, and documentation, and on career opportunities in nursing, including education, research, and travel nursing. Topics covered include both general nursing and all clinical specialties—emergency, critical care, medical-surgical, maternal-neonatal, and pediatric nursing. Numerous illustrations, graphs, and easy-to-follow quick-reference charts complement the text.

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Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies (Current Clinical Oncology)

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From the Back Cover

Imaging in Bariatric Surgery 1st ed. 2018 Edition

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About the Author

Clavicle Injuries: A Case-Based Guide to Diagnosis and Treatment 1st ed. 2018 Edition

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About the Author

Immunohistochemistry in Tumor Diagnostics 1st ed. 2018 Edition

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About the Author

Microdomains in the Cardiovascular System (Cardiac and Vascular Biology) 1st ed. 2017 Edition

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About the Author

Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence (Current Clinical Psychiatry)

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Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence continues the important work of the first book published in 2009 by Humana Press (Handbook of Evidence-Based Psychodynamic Psychotherapy:  Bridging the Gap Between Science and Practice).  This landmark title presents in one volume significant developments in research, including neuroscience research, in psychodynamic psychotherapy by a team of renowned clinician-researchers. The demand for ongoing research initiatives in psychodynamic psychotherapy from both internal and external sources has increased markedly in recent years, and this volume continues to demonstrate the efficacy and effectiveness of a psychodynamic approach to psychotherapeutic interventions in the treatment of psychological problems.  The work in this volume is presented in the spirit of ongoing discussion between researchers and clinicians about the value of specific approaches to specific patients with specific psychiatric and psychological problems. Multiple forms of treatment interventions have been developed over the past fifty years, and this volume makes clear, with firm evidence, the authors’ support for the current emphasis on personalized medicine.  Groundbreaking and a major contribution to the psychiatric and psychologic literature, Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence provides firm grounding for advancing psychodynamic psychotherapy as a treatment paradigm.

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