Noninferiority Testing in Clinical Trials: Issues and Challenges (Chapman & Hall/CRC Biostatistics Series) 1st Edition
[amazon template=iframe image2&asin=1466561491]
Take Your NI Trial to the Next Level
Reflecting the vast research on noninferiority (NI) designs from the past 15 years, Noninferiority Testing in Clinical Trials: Issues and Challenges explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a clinical trial. Requiring no prior knowledge of NI testing, the book is easily accessible to both statisticians and nonstatisticians involved in drug development.
With over 20 years of experience in this area, the author introduces the basic elements of the NI trials one at a time in a logical order. He discusses issues with estimating the effect size based on historical placebo control trials of the active control. The book covers fundamental concepts related to NI trials, such as assay sensitivity, constancy assumption, discounting, and preservation. It also describes patient populations, three-arm trials, and the equivalence of three or more groups.
DOWNLOAD THIS BOOK FREE HERE
This website strictly complies with DMCA Digital Copyright Laws..Please be clear that we (emedicalbooks.com) do not own copyrights of these e-books. The intention behind sharing these books and educational material is to provide easy access to medical students, doctors and other individuals related to the field of medical science, "thus only for educational purpose". We highly encourage our readers to purchase this content from the respected publishers. If anyone holding copyrights wants us to remove this content, please contact us rightaway. All books and educational material on emedicalbooks.com are free and NOT HOSTED ON OUR WEBSITE. If you feel that your copyrights have been violated, then please contact us immediately. You may send an email to firstname.lastname@example.org for all DMCA / Removal Requests. emedicalbooks.com doesn’t have any material hosted on the server of this page, only links to books that are taken from other sites on the web are published and these links are unrelated to the book server. emedicalbooks.com server doesnot store any type of book or material. No illegal copies are made or any copyright © and / or copyright is damaged or infringed since all material is free on the internet.