Category: Oncology

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Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

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Includes free CD-ROM! Completely revised and updated for 2010, the Physicians’ Cancer Chemotherapy Drug Manual is an up-to-date guide with the latest information on standard therapy and recent advances in chemotherapy. Written by world-class experts in the clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalogue of over 100 drugs and commonly used drug regimens – both on-and off-label – or the treatment of all major cancers. Special features include: * New drugs: Degarelix, Everolimius, and Nelarabine * Revised to reflect rapid advances in the field, incorporating new drug and treatment strategies * Diagrams of drug structures and pathways for each agent * Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages * Covers toxicity and drug-drug interactions * Includes a section on osteogenic sarcoma and chemotherapy regimens for all major cancers * Provides an overview of the basic principles of cancer drug therapy * Contains an easy to load and use CD-ROM version PDA version of Physicians’ Cancer Chemotherapy Drug Manual also available!

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Although distant metastases are the most dreaded situation in the evolution of cancer of every organ, the medical literature has surprisingly given little attention to the anatomical relationship between the primary tumor and metastasic sites. Only risk factors, treatment possibilities, and survival results are extensively examined.
Stimulated by the occurrence in his practice of some puzzling and unexpected metastases, the author reviewed more than 12,000 references. He looked for anatomical relationships highlighting the relation between the location of the primary tumors and the particular patterns of metastasis observed. It would seem that the `pathways and flows’ are apparently a more decisive factor in the implantation of the metastases than the `seed and soil’ properties of the cancer cells and the metastatic site.
Aided by his colleague Dr. T. Geukens, M.D., the author includes original anatomical drawings, illustrating the sometimes unexpected pathways the cancer cells follow in order to reach the organs where they will become lodged and give rise to metastatic tumors. The subject has apparently not been exhausted in the literature and several ideas are given for further research.

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This book provides many options for pain management in cancer patients, including pharmacological and nonpharmacological options,…[and] is well organized and easy to navigate. Score: 92, 4 Stars.–Doody’s Medical Reviews

Overall, [this book] is a comprehensive and wide-ranging text that, as proclaimed on the cover, is evidence-based and fully referenced. Practitioners and students alike will find it useful, and it deserves a place on the library shelf where people from a wide range of backgrounds can gain access.”–International Journal of Palliative Nursing

“[This] text is full of ‘clinical pearls’ based on [the authors’] extensive clinical experience with effective and ineffective pain management interventions√ñThe scope of the content in this text is extremely comprehensive√ñnewer content on the effect of opioid polymorphisms, cancer pain emergencies, myofascial pain, and chronic pain in cancer survivors places this text at the forefront in terms of cutting-edge issues in cancer pain management.”

Christine Miaskowski, RN, PhD, FAAN
Professor and Associate Dean for Academic Affairs
American Cancer Society Clinical Research Professor
Sharon A. Lamb Endowed Chair in Symptom Management Research
Department of Physiological Nursing
University of California, San Francisco, CA
From the Foreword

Although the prevalence of uncontrolled cancer pain remains unnecessarily high, research has indicated that 90% of cancer patients with pain can be successfully treated with standard therapies. This concise yet extremely comprehensive guide to managing cancer pain will enable nurses on the front lines of pain assessment and management to incorporate effective strategies into their daily practice. It offers quick access to current evidence-based guidelines for busy nurses and nurse practitioners working in all oncology care settings. To facilitate quick information retrieval, the text is designed in a consistently organized, bulleted format with highlighted key information and tools for assessment and standardized treatment. It also serves as an important review for the ONS and HPNA certification exam.

This book focuses on all aspects of cancer pain, including assessment and screening tools, pharmacologic and nonpharmacologic treatment options, current national guidelines for pain management, regional anesthesia techniques, patient-controlled anesthesia, and epidural pain management. It also includes updated information on the effect of opioid polymorphisms, cancer pain emergencies, myofascial pain, and chronic pain in cancer survivors. The book covers palliative care and end-of-life pain management, especially for patients who have symptoms that are not managed. Information on chronic pain conditions such as neuropathic pain in cancer and the use of adjuvant medications for pain control are included, along with special treatment options for addiction and substance abuse in the cancer population. The text additionally provides information on managing pain with difficult-to-treat populations.

Key Features:

• Provides current, evidence-based information on all aspects of cancer pain management
• Includes important new guidelines on using a combination of pain management scales for optimal pain assessment and management
• Describes interventional techniques for managing severe pain situations
• Organized for speedy information retrieval

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A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment.

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The only self–contained guide for practicing oncologists who treat patients with rare or infrequently encountered malignancies, this up–to–date resource offers a balanced, authoritative approach to the management of uncommon cancers. Now in its fourth edition, the book is thoroughly revised, including new material as well as new focus on evidence–based research and clinical practice throughout. Clinicians will find guidelines for addressing management issues, gain insight into real–world clinical decision–making, and save umpteen hours of research through the use of this widely acclaimed, comprehensive guide.

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