Category: Oncology

Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis (Chapman & Hall/CRC Biostatistics Series)

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Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. FDA and National Cancer Institute), and the pharmaceutical industry share their extensive experiences in cancer clinical trials and present examples taken from actual trials.

The book covers topics that are often perplexing and sometimes controversial in cancer clinical trials. Most of the issues addressed are also important for clinical trials in other settings. After discussing general topics, the book focuses on aspects of early and late phase clinical trials. It also explores personalized medicine, including biomarker-based clinical trials, adaptive clinical trial designs, and dynamic treatment regimes.

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Perry’s The Chemotherapy Source Book Fifth Edition

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Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs.  Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.

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Resistance to Targeted Therapies Against Adult Brain Cancers (Resistance to Targeted Anti-Cancer Therapeutics) 1st ed. 2016 Edition

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This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

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Cancer Cytogenetics: Methods and Protocols (Methods in Molecular Biology) 1st ed. 2017 Edition

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This volume provides readers with detailed protocols covering the main cancer cytogenetics techniques needed for clinical utilization and research purposes. The chapters in this book cover topics such as chromosome preparation for myeloid malignancies; chromosome bandings; fluorescence in situ hybridization probe preparation; array-based comparative genomic hybridization; and cytogenetic nomenclature and reporting. The updated reviews on chromosomal abnormalities in hematological malignancies are excellent guides for cytogenetics data interpretations and specific malignant diseases correlation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive, Cancer Cytogenetics: Methods and Protocols is a valuable resource for the novice in cytogenetics because it provides helpful guiding protocols, but it’s also great for those who are already engaged in the field and are looking for some technical hints.

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AIDS-Related Cancers and Their Treatment (Basic and Clinical Oncology) 1st Edition

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This book summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS.
Presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system.
Illustrates points with clear and easily read figures, tables, and flow charts!
Written to survey the magnitude of the impact HIV and AIDS have had on public health and oncology, AIDS-Related Cancers and Their Treatment

  • identifies types of cancer and gives evidence for their associations with immunosuppression
  • compares and contrasts AIDS-related cancer with non-HIV malignancies
  • investigates the pathogenesis of malignancy in HIV/AIDS patients
  • provides guidelines for recognizing possible symptoms and making accurate diagnoses
  • supplies algorithms for evaluating and staging patients at presentation
  • outlines potential problems and obstacles in caring for AIDS-related cancer patients
  • suggests optimal therapeutic approaches for the care of patients with AIDS and cancer
  • discusses prognostic factors in response to therapy and survival statistics
  • describes preliminary experience with emerging therapies and projects new approaches
  • advises how to enroll patients to participate in clinical trials of new therapies
  • considers the psychological impact on patients and their need for counseling and support
  • reviews access-to-care issues in AIDS and the community burden of this epidemic
  • provides information sources for both AIDS patients and their physicians
  • and more
    With contributions from nearly 25 clinicians and citing more than 1200 references to support and elaborate on text material, AIDS-Related Cancers and Their Treatment is a crucial reference for oncologists, immunologists, infectious disease specialists, hematologists, internists, microbiologists, virologists, epidemiologists, molecular and cell biologists, pathologists, and medical students in these disciplines.

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Surgical Oncology (Vademecum)

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This book meets the information needs of the medical student or surgical resident rotating on a surgical service which emphasizes oncology. It is also useful for the practicing general surgeon in reviewing the most current information on organ specific cancer therapy. It is not designed to be encyclopedic but distills important information about surgical oncology in a concise, up-to-date, and readable manner.

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Surgical Emergencies in the Cancer Patient 1st ed. 2017 Edition

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This text provides a comprehensive textbook summarizing the presentation, workup, and surgical solutions for common emergencies in the cancer patient. The use of medications (antibiotics, hormones, and biologic therapies) and interventional radiologic procedures as adjuncts or as replacements for the surgical solutions are discussed. The text covers emergencies that result as adverse effects for the systemic and local treatments for cancer, emergencies that result from mechanical issues with the cancer and those that result from surviving major extirpative surgery. Diagnosis and treatment of patients’ immune-compromised or thrombocytopenic status from chemotherapy is discussed, as is surgical treatment in patients with prior complex surgical therapy or radiation treatment. Finally, the text covers alternatives to surgery, including new interventional radiologic and endoscopic procedures.

Surgical Emergencies in the Cancer Patient will be of great value to healthcare professionals at all levels who are involved in the treatment of emergencies in the cancer patient. It is meant for a wide group of individuals, including medical students, residents in surgery and internal medicine, fellows in surgery and oncology, and practicing oncologists and surgeons. This work is meant to be a textbook for the student, a guide for the practitioner, and a reference for the general oncologist.
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Dynamics of Cancer : Mathematical Foundations of Oncology 1st Edition

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The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells.

Readership: Researchers in mathematical biology, mathematical modeling, biology, mathematical oncology.

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AOSpine Masters Series Volume 1: Metastatic Spinal Tumors (Aospine Master Series) 1st Edition

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This first volume in the AOSpine Masters Series
integrates the expertise of oncologists and radiology interventionalists with
that of master spine surgeons, all of whom are actively involved in the care of
patients with metastatic spine tumors. The book provides expert guidance to help
clinicians make the right treatment decisions and provide the best care for
their patients. Chapter topics range from evaluation and decision-making
principles to a spectrum of non-operative and operative treatment options that
have been rapidly evolving over the past decade.

Key
Features:

  • Editors are internationally-recognized authorities on
    metastatic spine tumors
  • Includes contributions from key opinion
    leaders working in spine oncology
  • Synthesizes the best available
    evidence and consensus expert advice on metastatic spine tumors, leading to
    optimal clinical recommendations
  • Each chapter includes clinical
    pearls, tips on complication avoidance, and “top 5 must-read references”

The
AOSpine Masters Series, a co-publication of Thieme and the AOSpine Foundation,
addresses current clinical issues whereby international masters of spine share
their expertise and recommendations on a particular topic. The goal of the
series is to contribute to an evolving, dynamic model of an evidence-based
medicine approach to spine care.

All neurosurgeons, orthopedic surgeons,
neuro-oncologists, and orthopedic oncologists specializing in spine, along with
residents and fellows in these areas, will find this book to be an excellent
guide that they will consult often in their treatment of patients with
metastatic spine tumors.

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