Category: Oncology

Metronomic Chemotherapy: Pharmacology and Clinical Applications

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This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

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Multimodal Treatment of Recurrent Pelvic Colorectal Cancer (Updates in Surgery) 1st ed

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This book analyzes all aspects of modern multimodal treatment of locally recurrent rectal cancer in the pelvis in order to offer a panoramic overview of the different therapeutic options and enable the reader to balance their benefits and drawbacks. Indications for surgery and the surgical techniques themselves, including reconstruction techniques after major exenterative surgery, are clearly described and evaluated. The role of new imaging tools, such as MRI and PET-CT, in staging recurrences and guiding therapy is assessed and detailed consideration is given to the use of neoadjuvant and iterative radiotherapy and the indications for systemic chemotherapy. Morbidity, mortality, oncologic outcomes, and quality of life issues are carefully analyzed and options for pain control and palliation are examined. Finally, a national survey is presented on the state of the art in the surgical treatment of locally recurrent rectal cancer in Italy. While there has been a dramatic fall in the incidence of local pelvic recurrences, their treatment remains a major clinical challenge which requires a multidisciplinary approach and careful selection of the most appropriate strategy in each case. This book will aid practitioners in making the correct decisions in individual patients.

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Urothelial Carcinoma: Methods and Protocols (Methods in Molecular Biology) 1st ed. 2018 Edition

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This volume details standard techniques for the characterization of urothelial carcinoma as well as methods to investigate mechanisms of carcinogenesis.  Chapters guide readers on cellular and animal models for urothelial carcinoma and related diseases, molecular analyses from body fluids, and new approaches to therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Urothelial Carcinoma: Methods and Protocols hopes that the techniques described in this volume will contribute to the current upturn in research on urothelial carcinoma and to the application of its results in clinical practice.

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Khan’s Treatment Planning in Radiation Oncology Fourth Edition

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This unique, full-color reference offers a total team approach to radiation oncology treatment planning, incorporating the newest imaging techniques and offering a comprehensive discussion of clinical, physical, biological and technical aspects.  A clear focus on the application of physical and clinical concepts to solve treatment planning problems helps you provide effective, state-of-the-art care for cancer patients. With authoritative coverage of the latest in sophisticated radiation oncology treatment modalities, the 4th Edition of Khan’s Treatment Planning in Radiation Oncology is an essential resource for the radiation oncologist, medical physicist, dosimetrist, and radiation therapist.

New to this edition:

  • Up-to-date material throughout reflects the most current practices in radiation oncology treatment.
  • New chapters discuss the pros and cons of recent developments in the field: Role of Protons vs. Photons in Modern Radiotherapy: Clinical Perspective, Intensity-Modulated Proton Therapy, and Radiobiology of Hypofractionated Regimens for SRS and SBRT.
  • New contributors bring a fresh perspective and provide current insight in their areas of expertise.
  • New Key Points and Study Questions at the end of each chapter online help you assess your understanding of the material.
  • Discussions of the scientific background and the key aspects of clinical approach ensure that you gain a well-rounded understanding of how to plan treatment from both a technical and a clinical perspective.

Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like:

  • Complete content with enhanced navigation
  • Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
  • Cross-linked pages, references, and more for easy navigation
  • Highlighting tool for easier reference of key content throughout the text
  • Ability to take and share notes with friends and colleagues
  • Quick reference tabbing to save your favorite content for future use

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Urothelial Carcinoma: Methods and Protocols (Methods in Molecular Biology) 1st ed

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This volume details standard techniques for the characterization of urothelial carcinoma as well as methods to investigate mechanisms of carcinogenesis.  Chapters guide readers on cellular and animal models for urothelial carcinoma and related diseases, molecular analyses from body fluids, and new approaches to therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Urothelial Carcinoma: Methods and Protocols hopes that the techniques described in this volume will contribute to the current upturn in research on urothelial carcinoma and to the application of its results in clinical practice.

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Changing Paradigms in the Management of Breast Cancer 1st ed

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This text is designed to present a comprehensive and state-of the-art approach to the management of breast cancer within the fields of surgery, medical oncology, and radiation oncology.  Sections address changes in these fields. These areas include breast imaging,  management of the axilla, atypical breast lesions, surgical margins, new techniques in breast reconstruction, and nipple sparing and contralateral mastectomies. Subsequent chapters focus on issues in medical oncology including,  triple negative breast cancer and metastatic breast disease. New paradigms in radiation oncology are examined.  Breast cancer treatment in the elderly and in young women, and genetic risk in breast cancer management is also be discussed. Written by experts in their field, each of these sections addresses advances and changes in the field. A brief review of the existing literature addressing the particular topic follows in each section.  The text concludes with chapters on pathological issues and advances in radiation oncology.

As access to a comprehensive multidisciplinary resource such as this is currently limited in the literature, Changing Paradigms in the Management of Breast Cancer represents the first single source to provide information on advances and outcomes for the physician caring for breast cancer patients in a multidisciplinary setting.

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Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract (Advances in Experimental Medicine and Biology) 1st ed. 2016 Edition

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About the Author

Frontiers in Ovarian Cancer Science (Comprehensive Gynecology and Obstetrics) 1st ed. 2017 Edition

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This volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease.

In terms of basic medicine, the WHO Classification of Tumors of Female Reproductive Organs was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas.

Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades, making it essential to pursue multidisciplinary treatment and apply novel techniques such as neoadjuvant chemotherapy in daily clinical practice. The primary clinical task is the effective treatment of recurrent ovarian cancer with early palliative medicine. Fertility-sparing surgery may also be pursued depending on histologic subtypes, stage, extent of disease, and preexisting ovarian reserve with the concept of oncofertility.

On the basis of the considerations described above, each expert author elucidates the science of ovarian cancer in detail, thus providing a collection that will benefit young medical oncologists and seasoned gynecologists and obstetricians alike.

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Clinical Ophthalmic Oncology: Orbital Tumors 2nd ed

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Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. This volume describes the classification, differential diagnosis, and imaging of orbital tumors and discusses the most suitable treatment options for different tumor types.​

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Oncology: An Evidence-Based Approach (Chang, Oncology)

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“This is an extremely informative book. … This book aims to give an evidence-based approach to oncology. … It should be recommended reading for any health professional … . The section on survivorship sets this book apart from other similar texts. … a good book, and a useful addition to the library of the practising Oncologist. … It certainly has great strengths in it’s involvement of cancer survivors, its strong use of quality data and its careful balancing of benefit and toxicity of anti-cancer therapy.” (Dr. Simon Grumett, Oncology News, Vol. 1 (2), 2006)

“This text … has the physical gravitas of a worthy scholarly tome. … Oncology is a different textbook on the subject. It opens … with an introduction to an evidence-based approach to oncology. … my impression of this book overall is highly favorable – it provides comprehensive coverage of the basics, with extensive information about new areas. … oncologists will enjoy exploring it in their leisure time.” (Robyn Ward, The New England Journal of Medicine, July, 2006)

“This book looks at the complexity of oncology by utilising an evidence-based approach. … it is easy to read and should capture the reader’s attention due to the layout and style in which it is written. … Overall a great book providing comprehensive coverage of the evidence-based approach to oncology, allowing the readers to make their own decisions. I would recommend this book to all health professionals who have an interest in oncology.” (Di Saward, CancerForum, Vol. 30 (3), November, 2006)

“This concise book is a current source of information on all major cancers, diagnostic methods, and several general topics of interest for those caring for oncology patients. … This is a well-referenced textbook of oncology. … This textbook would be useful for anyone reading to stay up-to-date on a topic. … Recommended Readership: Internists with an interest in cancer, oncologists, oncology trainees, allied health service and nurse practitioners, and physician assistants who deal with patients with cancer. Medical libraries should have this book.” (Ravi D. Rao, Mayo Clinic Proceedings, Vol. 81 (5), May, 2006)

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