Oxford Handbook of Medical Statistics (Oxford Medical Handbooks) 1st Edition

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To practice evidence-based medicine, doctors need to understand how research is conducted and be able to critically appraise research evidence. A sound understanding of medical statistics is essential for the correct evaluation of medical research and the appropriate implementation of findings in clinical practice.
Written in an easily accessible style, the Oxford Handbook of Medical Statistics provides doctors and medical students with a concise and thorough account of this often difficult subject. It promotes understanding and interpretation of statistical methods across a wide range of topics, from study design and sample size considerations, through t- and chi-squared tests, to complex multifactor analyses, using examples from published research. References for further reading are given for more information on specific topics.
Helping readers to conduct their own research or critically appraise other’s work, this volume provides all the information readers need to understand and interpret medical statistics.

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Circadian Rhythms and Their Impact on Aging (Healthy Ageing and Longevity) 1st ed. 2017 Edition

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Hemodiafiltration (Contributions to Nephrology, Vol. 158) 1st Edition

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The application of hemodiafiltration has been restricted until recently, when a broader clinical application has been made possible due to evidence from large studies and clinical investigations. This book provides an updated review of the evolution, advances and recent results achieved by hemodiafiltration in the clinical arena. The first part is devoted to historical notes and an outline of the evolution of different forms of hemodiafiltration, made possible by technological developments in the fields of membranes, machines and fluids. The next section describes the theoretical rationale for hemodiafiltration, providing a detailed analysis of the involved mass separation processes, the hydraulic properties of the dialyzers, fluid mechanics and crossfiltration in hollow fiber hemodialyzers. An outline of different hemodiafiltration techniques, also reporting peculiar transport mechanisms and related technology, is given next, and a section on the clinical effects of hemodiafiltration concludes this book. Including different technologies, the publication offers a complete overview of the technical and clinical possibilities provided by hemodiafiltration in its widest concept, ranging from the molecular basis to the most practical application. It will be a valuable tool for the implementation of hemodiafiltration in daily practice aimed at beginners and experts, scientists and physicians, students and senior faculty members alike.

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Astrovirus Research: Essential Ideas, Everyday Impacts, Future Directions

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Astroviruses were first identified in the feces of children in 1975.  Since then, they have been found in ~ 3 to 20% of children with diarrhea.  Given that serological studies have demonstrated that up to 90% of children have been exposed to at least one strain of astrovirus by age 9, the prevalence of infection may be much higher.  Supporting this are studies demonstrating that astroviruses can also be isolated in a subset of asymptomatic individuals, suggesting that a proportion of infected individuals shed the virus asymptomatically or for some time after the resolution of other symptoms of infection.  Asymptomatic carriers may be a major reservoir for astroviruses in the environment and could contribute to dissemination of the virus.  Astroviruses are extremely stable in the environment and can be transmitted nosocomially, directly from infected individuals and potentially animals, and through contaminated food and water. Although typically an acute disease, astrovirus infection in premature infants may be associated with the development of necrotizing enterocolitis and in new-onset celiac disease in children.  Immunocompromised children are even more susceptible often developing persistent infections that lead to wasting or even systemic infections associated with fatal encephalitis.   In spite of its importance, little is known about astrovirus pathogenesis, molecular biology, epidemiology, or cell biology.  The goal of this book is to provide the latest and most up-to-date information on this medically important and rapidly evolving group of viruses.  It will include sections on the history of astroviruses and their disease in humans; information on viral replication and immune responses; new information on how astroviruses induce disease including the expression of a viral enterotoxin regulating intestinal epithelial cell tight junctions, the isolation and identification of new astrovirus genotypes in mammals including humans, and astroviruses of veterinary importance.  Finally, the book will also introduce the complexity of astrovirus epidemiology and potential as an important new zoonotic disease, and its role in food-borne disease.  This will be the first book of its kind and will be of great interest to microbiologists, virologists, infectious disease specialists, immunologists, pediatricians, public health and food safety experts, veterinarians, poultry industry specialists, and researchers and clinicians interested in enteritis. ​

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RNA Nanostructures: Methods and Protocols (Methods in Molecular Biology) 1st ed. 2017 Edition

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This volume presents a collection of computational and experimental protocols pertaining to the creation, characterization, and utilization of RNA nanostructures. The chapters in this book cover topics such as ion effects in RNA folding; design and crystallography of self-assembling RNA nanostructures; x-aptamer selection and validation; RNAi in HIV-infected cells; and preparation of a conditional RNA switch. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, RNA Nanostructures: Methods and Protocols is a valuable resource for the design and production of RNA nanostructures. Researchers and scientists sharing these detailed protocols is important for sustained progress in the field.

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Juvenile Angiofibroma 1st ed. 2017 Edition

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About the Author

Siba P. Dubey, MBBS, MS

Siba Dubey obtained his MBBS degree from Calcutta University in 1982. He trained in Otolaryngology – Head and Neck Surgery (ORLHNS) at the Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. He completed his thesis on “Computed tomography (CT) in Ear diseases – Correlation between CT and surgical findings” and passed Master of Surgery (MS) in ORLHNS in December, 1986. Subsequently, he underwent advanced training in ORLHNS in India and Austria. He came to Papua New Guinea (PNG) in November 1994 to take up the position of Chief  Ear, Nose and Throat (ENT) Surgeon. The specialty of ORLHNS grew bigger from one to multiple centres across PNG with the help of locally trained ENT specialists. He became Professor at the School of Medicine and Health Sciences, University of Papua New Guinea in 2002. Since then, he has been involved in the teaching and training of Undergraduate and Postgraduate students of PNG and other Pacific Island countries.

He has performed research on clinical and operative aspects, malignancies of head and neck, and tropical diseases, namely, angiofibroma, scleroma etc. These works are published in international journals and in books.

Bernhard Schick, MD

After studying medicine at the Philipps-University in Marburg, Germany from 1987 to 1993 he completed his doctor thesis in 1993. Entitled “Enzymatic analysis of myosin-subfragment-1 induced actin polymerisation” the thesis was honoured by the note “summa cum laude”. ENT specialization took place under the supervision of Prof. Dr. Dr. W. Draf (Fulda-Hospital, Germany) from 1994 ton 1998. Specialization for plastic head and neck surgery was successfully achieved under the supervision of Prof. Dr. Dr. W. Draf (Fulda Hospital, Germany) from 1998 to 2000. As the representative of the Head at the ENT-Department at the Saarland University (Prof. Dr. P.K. Plinkert) from 2000 to 2003 habilitation was successfully finished in 2003, presenting new findings of inner ear mechanics analysing VASP expression in the inner ear with the chance to analyse hearing in VASP-/- mice by detailed electrophysiological examinations. He has been Head of the ENT-Department at the Saarland University since June 2008, and is now Medical Director of Uniklinikum Saarland and CEO.

During a 20 year period extensive studies have been performed on juvenile angiofibromas, from genetic and molecular studies to clinical evaluations including radiological tumor presentation, surgical strategies and development of an etiological model describing tumor genesis.

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Substance Use Disorders: A Guide for the Primary Care Provider Paperback – October 20, 2017

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Early Repolarization Syndrome: Etiology and Therapeutics 1st ed. 2018 Edition

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Glycobiology of the Nervous System (Advances in Neurobiology) 2014th Edition

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A thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic information as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. The breadth and depth of topics covered make it an essential reference for those new to the field as well more seasoned investigators.

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Diagnostic Cytopathology Board Review and Self-Assessment

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Diagnostic Cytopathology Board Review and Self-Assessment provides a comprehensive systems-based review of non-gynecological cytology including cytomorphology, pitfalls and ancillary studies, presented in a high-yield format with board-type multiple choice questions and detailed answers. It provides an excellent review, resource and self-assessment for pathologists, cytopathologists and cytotechnologists, as well as trainees (pathology residents, cytopathology fellows and cytotechology students) who are preparing for board examinations or in-service examinations, in addition to those who are looking to fine-tune their cytology diagnostic skills. The volume is organized in a systems-based format including chapters covering lung, lymph nodes, pancreas, liver, gastrointestinal tract, thyroid, salivary gland, central nervous system, soft tissue and bone, kidney, adrenal, retroperitoneal and exfoliative cytology of urine, serous fluids and CSF. This book is enriched with the following features to maximize studying and review of cytopathology” HIGH YIELD REVIEW: Concise high-yield review with tables emphasizing key points, useful criteria and important concepts to maximize your score on board examinations and your diagnostic knowledge of exfoliative and aspiration cytopathology. BOARD EXAM-TYPE QUESTIONS: Over 800 board exam-type questions covering all areas of non-gynecological cytology with emphasis on cytomorphology, diagnostic pitfalls and ancillary studies, including detailed answers with in-depth discussions and key references from the literature and major cytopathology text books. HIGH QUALITY FULL-COLOR IMAGES: Over 600 high-quality full-color photomicrographs, including images of immunohistochemical stains and other ancillary studies performed.

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