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  • Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects 1st Edition

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  • Systemic Lupus Erythematosus (Oxford Rheumatology Library) Illustrated Edition

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  • Systemic Lupus Erythematosus

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  • Systemic Lupus Erythematosus: Methods and Protocols (Methods in Molecular Biology, 1134) 2014th Edition

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  • Lupus Renal Involvement: A Case-based Atlas UK ed. Edition

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  • Dubois’ Lupus Erythematosus and Related Syndromes – E-Book: Expert Consult – Online and Print 9th Edition

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  • Advanced Handbook of Systemic Lupus Erythematosus 1st ed. 2018 Edition

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Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects 1st Edition

Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects 1st Edition

Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

  • Provides the very latest overview of the pathogenesis of SLE
  • Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease
  • Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more
  • Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage
  • Discusses the latest treatment options on disease modifying or disease controlling agents
  • Provides ‘one stop’ coverage of all the latest scientific and clinical developments in SLE

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Systemic Lupus Erythematosus (Oxford Rheumatology Library) Illustrated Edition

Systemic Lupus Erythematosus (Oxford Rheumatology Library) Illustrated Edition

Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body’s cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and
treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and
contract research organizations.

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Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

This book provides a comprehensive overview of the basic and clinical sciences of Systemic Lupus Erythematosus. It is suitable for basic scientists looking for detailed coverage of their areas of interest. It describes how advances in molecular biology have increased our understanding of this disease. It is a valuable clinical resource for practicing clinicians from different disciplines including rheumatologists, rheumatology fellows and residents. This book provides convenient access to information you need about cytokines, genetics, Fas pathway, toll like receptors and atherogenesis in SLE. Animal models have been reviewed as well. How to avoid delay in SLE diagnosis and management, in addition to various clinical manifestations including pregnancy and SLE have all been explained thoroughly in this book.

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Systemic Lupus Erythematosus: Methods and Protocols (Methods in Molecular Biology, 1134) 2014th Edition

Systemic Lupus Erythematosus: Methods and Protocols (Methods in Molecular Biology, 1134) 2014th Edition

Systemic Lupus Erythematosus: Methods and Protocols describe a number of genetic, biochemical and immunological techniques. These techniques provide an advancing understanding of the pathology, breakdown of the immune system and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Systemic Lupus Erythematosus: Methods and Protocols appeal to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level.

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Lupus Renal Involvement: A Case-based Atlas UK ed. Edition

Lupus Renal Involvement: A Case-based Atlas UK ed. Edition

Systemic lupus erythematosus (SLE or lupus) is a fairly common disease with a relatively high mortality rate that is characterized by multisystemic disorders, including the kidney. Recently, epidemiologic studies also show that the incidence of new SLE cases is increasing. Renal involvement is very common in systemic lupus erythematosus, occurring in up to 2/3 of patients and is a major cause of morbidity and mortality. Lupus nephritis affects glomeruli, tubules, interstitium peritubular capillaries, arteries, and veins with a spectrum of lesion. Although tubular, interstitial, and vascular lesions are common in lupus nephritis and may contribute significantly to overall disease severity, activity, and chronicity, they are not considered in most important classifications (OMS and ISN/RPS). These classifications are based entirely on the evaluation of glomerular alterations. Furthermore, the increasingly recognized, new pathological entity called lupus podocitopathy in the context of SLE, is not also accepted in the above classifications. Amyloidosis, non-lupus nephritides (including IgA nephropathy), therapeutic nephrotoxicity, and lupus in overlap with other connective tissue diseases are occasionally described. Therefore, this new case-based book fills a gap in the literature, and the authors call attention to some clinical entities which are less known and more difficult to recognize. The book design allows correlating morphologic aspects with clinical findings, and determines the prognosis and therapeutic response. It is a useful resource for pathologists, nephrologists, rheumatologist, physicians, and lupus and kidney students. Each case consists of typical histology images, a brief history, diagnosis, discussion, and pearls and pitfalls. The book is based on a multicenter experience, and the importance of kidney biopsy in the differential diagnosis is emphasised.

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Dubois’ Lupus Erythematosus and Related Syndromes – E-Book: Expert Consult – Online and Print 9th Edition

Dubois’ Lupus Erythematosus and Related Syndromes – E-Book: Expert Consult – Online and Print 9th Edition

For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes.

  • Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.
  • Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients.
  • Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS).
  • Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment.
  • Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

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Advanced Handbook of Systemic Lupus Erythematosus 1st ed. 2018 Edition

Advanced Handbook of Systemic Lupus Erythematosus 1st ed. 2018 Edition

This book will provide an introduction to the epidemiology, etiology and pathogenesis of the condition while also exploring the classification, diagnosis, and current and emerging therapies for systemic lupus erythematosus. Systemic lupus erythematosus is an autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs. The underlying cause of the disease is not fully known, and SLE is much more common in women than in men. It may occur at any age but most often occurs in people between 10 and 50 years of age. This is the second Adis title from Ronald F van Vollenhoven, who previously authored Biologics for the Treatment of Rheumatoid Arthritis.

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Type 2 Immunity: Methods and Protocols (Methods in Molecular Biology, 1799) 1st ed. 2018 Edition

Type 2 Immunity: Methods and Protocols (Methods in Molecular Biology, 1799) 1st ed. 2018 Edition

This book provides researchers the opportunity to investigate type-2-associated diseases in their laboratories. Beginning with chapters describing various models of type-2 immunity, the volume then continues by detailing cellular protocols designed to identify, characterize, and assess the function of key adaptive and innate immune cells involved in type-2 inflammation; approaches to isolate and evaluate specific cellular subsets at the genetic, epigenetic, and molecular level; protocols to assess type-2 immunity and its relationship to organismal and metabolic systems (ex. Microbiome). This book concludes with a section that explores the use of primary human cells in evaluating relevance to the clinic. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshootingand avoiding known pitfalls.

Vital and authoritative, Type 2 Immunity: Methods and Protocols aims to provide a broad network of methods that can be used to develop a hypothesis and investigate its potential from bench to beside.

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Systems Immunology: An Introduction to Modeling Methods for Scientists (Foundations of Biochemistry and Biophysics) 1st Edition

Systems Immunology: An Introduction to Modeling Methods for Scientists (Foundations of Biochemistry and Biophysics) 1st Edition

“Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together.”

–Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA

New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined.

Readers from immunology, quantitative biology, and applied physics will benefit from the following:

  • Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels.
  • An overview of basic concepts in modeling and data analysis.
  • Coverage of topics where mechanistic modeling has contributed substantially to current understanding.
  • Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

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The 21-Day Immunity Plan

The 21-Day Immunity Plan

**THE SUNDAY TIMES BESTSELLER**

‘Brilliant! It’s hard to change your life – but this book gives you all the reasons it’s possible. From the first page to the last, one revelation after another.’
JEREMY VINE

‘Brilliant . . . especially required reading in these COVID-19 days’
LIZ EARLE

‘Metabolism, inflammation, and immunity are three sides of the same coin. Fix one and you fix them all. Dr Aseem Malhotra offers you a way to fix all three at once, and the solution is as easy as your fork.’
PROFESSOR ROBERT LUSTIG, bestselling author of Fat Chance

‘This remarkable book will change your life. Beautifully written, it compiles in one place the health messages we all know make sense.
PROFESSOR KAROL SIKORA, leading cancer specialist and Founding Dean, University of Buckingham Medical School

‘Read this book and follow the plan, it may save your life.’
GURINDER CHADHA, OBE, director of Bend It Like Beckham

‘A crystal-clear roadmap to reverse the roots causes of our poor metabolic and immune health. It is the handbook of health for our time.’
MARK HYMAN, New York Times bestselling author of Food Fix

*******

The simple, evidence-based diet plan to rapidly improve your metabolic health, help with normal immune function and likely reduce the risk of severe effects from Covid-19.

Dr Aseem Malhotra is a leading NHS-trained cardiologist and a pioneer of lifestyle medicine. He has been at the forefront of citing the health conditions which make us vulnerable to the worst effects of Covid-19. Obesity, Type 2 diabetes and heart disease are high among them – and all indicators of poor metabolic health.

The good news is that in just 21 days we can prevent, improve and even potentially reverse many of the underlying risk factors that exacerbate how infections, including Covid-19, affect us and improve our ability to recover from them.

Giving us the evidence-based science behind the plan, Dr Malhotra shares how simple changes to our diet as well as daily exercise and stress relief can have remarkable results in improving our markers for metabolic health, even helping to put Type 2 diabetes into remission, reduce risk factors for heart disease, decrease weight and enhance vitality.

Arguing for the huge benefits to global health of these highly effective lifestyle changes, he shows how just 21 days can help us to start the journey to lead a healthier and longer life.

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