Tag: Oncology

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International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression

Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy.  With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development.

A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.

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This book provides an overview of recent advances in radiation oncology, many of which have originated from physics and engineering sciences. After an introductory section on basic aspects of 3D medical imaging, the role of 3D imaging in the context of radiotherapy is explored in a series of chapters on the various modern imaging techniques. A further major section addresses 3D treatment planning for conformal radiotherapy, with consideration of both external radiotherapy and brachytherapy. Subsequently the modern techniques of 3D conformal radiotherapy are described, including stereotactic radiotherapy, intensity-modulated radiation therapy, image-guided and adaptive radiotherapy, and radiotherapy with charged particles. More clinically oriented chapters explore the use of brachytherapy in patients with prostate cancer, cardiovascular disorders and breast cancer. The book concludes with a section on quality assurance. The text is specifically designed to be accessible to professionals and students with a medical background as well as to newcomers to radiation oncology from the field of physics.

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While patients with metastatic renal cell carcinoma (mRCC) are now living longer with improved quality of life, the success of novel therapies for mRCC has created challenges for practicing oncologists. Many patients who initially respond to targeted therapies ultimately develop progressive disease due to acquired resistance to these agents. Additionally, some patients do not respond at all to any of the currently approved targeted agents, underscoring the need for continued and concerted efforts to identify other relevant targets and pursue alternative therapeutic strategies. Part of the Oxford American Oncology Library, Renal Cell Carcinoma is a concise handbook that addresses the complex management of patients with mRCC. The book begins with a review of the epidemiology, pathology, and biology of renal cell carcinoma followed by chapters on specific targeted therapies and managing complications. The final chapters discuss supportive and integrative care and emerging therapies.

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Ace the oncology boards with the field’s most comprehensive self-paced review! Based on DeVita, Lawrence, and Rosenberg’s Cancer: Principles & Practice of Oncology, Ninth Edition, this in-depth question-and-answer review and workbook covers the entire specialty of oncology and provides thorough preparation for oncology boards.

Inside, readers will discover hundreds of multiple-choice and case-based questions covering the principles of surgical oncology, radiation oncology, medical oncology, and hematology/oncology and the biology, diagnosis, staging, and multimodality treatment of cancers at every anatomic site. Included are state-of-the-art chapters on molecular techniques, targeted therapies, and current approaches to cancer prevention.

Detailed answers and explanations follow the questions to help readers grasp the ‘how and ‘why’ behind each correct response. The ideal way to maximize exam scores for today’s student and residents.

Learning and review features include…
• Hundreds of multiple-choice and case-based questions to build comprehension and improve retention.
• All topics cross-referenced to the latest edition of DeVita, Hellman, and Rosenberg’s CANCER: Principles & Practice of Oncology, Ninth Edition
• Material on all aspects of oncology, including medical, radiation and surgical oncology, as well as hematology/oncology issues
• FREE interactive online question bank, featuring multiple-choice and case-based questions, lets readers learn at their own pace and convenience from any computer—perfect for individual self-assessment!

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