Category: Pharmacology

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About the Author

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Heparins remain amongst the most commonly used drugs in clinical practice.  Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.

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Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.

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Learn the essential principles of pharmacotherapy and how they apply to today’s healthcare

Pharmacotherapy Principles & Practice, Third Edition uses a solid evidence-based approach to teach you how to design, implement, monitor, and evaluate medication therapy. This trusted text provides everything you need to gain an in-depth understanding of the principles essential to the optimal pharmacotherapy of disease. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in clinical practice. Chapters were written or reviewed by pharmacists, nurse practitioners, physician assistants, and physicians who are authorities in their fields.

The book opens with an introductory chapter followed by chapters on pediatrics, geriatrics, and palliative care. The remainder of the text consists of ninety-eight disease-based chapters that review etiology, epidemiology, pathophysiology, and clinical presentation, followed by therapeutic recommendations for drug selection, dosing, and patient monitoring.

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This practical guide presents the most up-to-date information on the application of non-pharmacological and physical therapeutic measures, either used independently or in combination with pharmacotherapy, for the management of osteoporosis. Pharmacotherapy remains the primary treatment for osteoporosis, but to improve the biomechanical competence of bone and improve quality of life, there needs to be more comprehensive management approach involving non-pharmacological methods. The book opens with a discussion of the diagnosis, pathophysiology, complications and consequences of osteoporosis. Exercise, nutrition, orthotics, and other rehabilitation measures such as whole body vibration and electrical muscle stimulation, each described in details in chapters of their own, have had a beneficial impact on fall and fracture prevention as well as recovery post-fracture. In addition, the application of acupuncture for pain management and movement-based mind-body therapies like tai chi and the Feldenkrais method are explored.

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Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened up a completely new line of research in an effort to establish a function for GHB.

Gamma-Hydroxybutyrate: Pharmacological and Functional Aspects has brought together the combined expertise of many of the leading authorities on the biochemistry, physiology and pharmacology of GHB in the central nervous system. Each chapter is an in-depth review of the field and the book itself will appeal to all neurobiologists interested in neurotransmitter mechanisms, as well as to clinicians and other health-care workers interested in this fascinating chemical.

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From the Back Cover