Sleep, Circadian Rhythms, and Metabolism: The Rhythm of Life 1st Edition

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Providing a nuanced study of the connections between sleep, circadian rhythms, and metabolis, this informative book examines how circadian actions affect the liver and adipose tissue, the brain, and metabolism. This important book introduces the reader to circadian rhythms in the body and the external cues that set them, discusses on a molecular and organ level how disrupting these clocks results in metabolic and sleep disorders, and looks at the clinical applications of circadian rhythms, with a focus on sleep.

The book covers a variety of important research in the field, including:

• The power of computational biology to uncover new nodes in the network of circadian rhythms

• Circadian rhythms as they relates to obesity

• How late-night shift conditions impair the body’s ability to keep time and promote metabolic diseases and how this can be mitigated by strategic planning of feeding times

• The relationship between the suprachiasmatic nuclei and orexin neurons, demonstrating the elegant interplay between our biological clocks and wakefulness

• How sleep disorders can result from irregular circadian rhythms and potential ways to diagnose this in individuals

• How sleeping behaviors can disturb the hypothalamic-pituitary-adrenal axis and the repercussions of this disruption on female reproduction

• How disruption of sleep can be clinically beneficial for depressed patients

• How mental state is influenced by circadian rhythm

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Health and the Gut: The Emerging Role of Intestinal Microbiota in Disease and Therapeutics 1st Edition

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The study of the intestinal ecosystem of bacteria in the human gut―the gut microbiome―is a new field that is rapidly evolving. This book serves as an introduction to some of the new and exciting research that is being done in this field. Included are chapters that examine the following:

• Gut microbiome’s roles in the pathogenesis of obesity and autoimmune disease

• The effect of nutrition on the richness of the microbial community

• The stability of the microbiome to various stressors

• Emerging ways to diagnose diseases using the microbiome

• Exciting prospects for using these microbes to cure disease

This easily accessible reference volume offers a comprehensive guide to this relatively new field of study. Edited by a researcher from Yale University, Health and the Gut: The Emerging Role of Intestinal Microbiota in Disease and Therapeutics is an authoritative and easy-to-use reference, ideal for both researchers in the field and those who wish to gain more information about the impact of gut microbiota on human health.

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The Health Professional’s HPV Handbook: Human Papillomavirus and Cervical Cancer 1st Edition

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This compact, illustrated handbook is a concise but comprehensive resource that introduces medical students, general medical practitioners and gynecologists to the significance of the human papillomaviruses in the etiology of cervical cancer. All chapters are fully referenced and written by experts in the field. The content review virus structure, the epidemiology of HPV, the latest advances in HPV vaccination, and new markers for cervical disease.

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Royal Society of Medicine Career Handbook: ST3 – Senior Doctor 1st Edition

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Whether you are just starting out as a senior doctor or half way up the ladder, this book will give you the help and advice you need to develop your career pathway in primary care or hospital medicine and achieve success in your professional life.

Simple, practical tips; strategies; and well-researched advice will empower you to:

  • Excel when applying and interviewing for that all-important ST3 position
  • Achieve examination success in your chosen specialty
  • Make the most of conferences, courses, and other networking opportunities
  • Obtain research funding and choose research areas
  • Deal with workplace politics and management challenges
  • Make the right decisions in choosing your final job, whether at home or overseas

Brimming with sound practical advice, hints, and tips, this text with its readily accessible style and approach is an essential survival guide for all embarking on their carrer as a senior doctor.

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Inflammatory Skin Disorders (Demos Surgical Pathology Guides) 1st Edition

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“The Demos Surgical Pathology Guides series presents in summary and visual form the basic knowledge base that every practicing pathologist needs every working day. Series volumes cover the major specialty areas of surgical pathology, and coverage emphasizes the key entities and diagnoses that pathologists will see in practice, and that they must know whether in training or practice. The emphasis is on the basic morphology with newer techniques represented where they are frequently used. The series provides a handy summary and quick reference that any pathology resident or fellow will find useful. Experienced practitioners will find the series valuable as a portable œrefresher course” or review tool.

Inflammatory Skin Disorders, the third volume in the Demos Surgical Pathology Series provides essential information on a range of key inflammatory skin diagnoses, including but not limited to those that pathologists commonly see in daily practice. Inflammatory Skin Disorders describes the major patterns of skin inflammatory conditions along with the most common entities included in each differential diagnosis.

The chapters cover the histologic patterns including inflammatory reactions primarily involving the epidermis, the dermis, and the subcutaneous tissue, cutaneous deposition and metabolic disorders, infectious diseases of the skin, and more. Inflammatory Skin Disorders is highly illustrated throughout and provides a handy summary and quick reference guide for pathology residents and serves as a useful quick reference guide for the more experienced pathologist.”

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Essentials of Haematology 2nd Edition

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The second edition of Essentials of Haematology brings students fully up to date with common haematologic disorders and blood transfusion, with an emphasis on pathogenesis, diagnosis and treatment. Divided into five sections, topics include blood physiology, red and white blood cell disorders, haemostasis disorders and blood transfusion. Each chapter discusses the diagnosis and treatment of a different disorder and the final section describes transfusion techniques. This comprehensive new edition includes more than 400 full colour figures, tables and illustrations with descriptions to assist learning. Key points * New edition bringing students up to date with common haematologic disorders and blood transfusion * Emphasis on pathogenesis, diagnosis and treatment * Includes more than 400 full colour figures, tables and illustrations * Previous edition published in 2006

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Hereditary Colorectal Cancer: Proceedings of the Fourth International Symposium on Colorectal Cance

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Since the success in chemical induction of cancer in rabbit’s ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen­ tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino­ genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri­ zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ­ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.

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Brain, Mind, and the Structure of Reality 1st Edition

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Does the brain create the mind, or is some external entity involved? In addressing this “hard problem” of consciousness, we face a central human challenge: what do we really know and how do we know it? Tentative answers in this book follow from a synthesis of profound ideas, borrowed from philosophy, religion, politics, economics, neuroscience, physics, mathematics, and cosmology, the knowledge structures supporting our meager grasps of reality. This search for new links in the web of human knowledge extends in many directions: the “shadows” of our thought processes revealed by brain imagining, brains treated as complex adaptive systems that reveal fractal-like behavior in the brain’s nested hierarchy, resonant interactions facilitating functional connections in brain tissue, probability and entropy as measures of human ignorance, fundamental limits on human knowledge, and the central role played by information in both brains and physical systems.

In Brain, Mind, and the Structure of Reality, Paul Nunez discusses the possibility of deep connections between relativity, quantum mechanics, thermodynamics, and consciousness: all entities involved with fundamental information barriers. Dr. Nunez elaborates on possible new links in this nested web of human knowledge that may tell us something new about the nature and origins of consciousness. In the end, does the brain create the mind? Or is the Mind already out there? You decide.

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Oxford Handbook of Clinical Specialties (Oxford Medical Handbooks) 9th Edition

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Now in its 25th year, the Oxford Handbook of Clinical Specialties has been revised and updated by a trusted author team to bring you practical, up-to-date clinical advice and a unique outlook on the practice of medicine. Twelve books in one, this is the ultimate guide to the core clinical specialties for students, junior doctors, and specialists.

This edition features a new and improved referencing system guided by a team of junior doctors, ensuring that the text is packed with valuable references to the most salient data and guidelines across the specialties. Each chapter has been updated on the advice of a team of specialists, to bring you everything you need for any eventuality on the ward or in the field. This essential handbook guides the reader through the management of an unprecedented spectrum of conditions and eventualties, from sexual health to major incident management. Compact and filled with high quality artwork, directions to further reading, and wise advice, this book is an ideal resource for revision and reference on the go.

With its companion volume, the Oxford Handbook of Clinical Medicine, the Oxford Handbook of Clinical Specialties offers a unique perspective on the practice of medicine. Filled with wit, wisdom, and humanity, this book draws on literature, history, and personal experience to teach a philosophy of medicine that always puts the patient at the centre of compassionate care. It is a trustworthy companion for anyone with the spirit of self-improvement and a passion for their practice.

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