Biodemography of Aging: Determinants of Healthy Life Span and Longevity

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This volume is a critical exposition of the data and analyses from a full decade of rigorous research into how age-related changes at the individual level, along with other factors, contribute to morbidity, disability and mortality risks at the broader population level. After summarizing the state of our knowledge in the field, individual chapters offer enlightening discussion on a range of key topics such as age trajectory analysis in select and general populations, incidence/age patterns of major chronic illnesses, and indices of cumulative deficits and their use in characterizing and understanding the detailed properties of individual aging.
The book features comprehensive statistical analyses of unique longitudinal data sets including the unique resource of the Framingham Heart Study, with its more than 60 years of follow-up. Culminating in penetrating conclusions about the insights gained from the work involved, this book adds much to our understanding of the links between aging and human health.
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Pediatric Rheumatology: A Clinical Viewpoint 1st ed. 2017 Edition

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This book on rheumatology in children is intended to be a handy tool for all professionals interested in this field. It is divided into five sections: General considerations, arthritic problems, connective tissue diseases, systemic vasculitides and finally a section that covers miscellaneous issues such as Immunodeficiencies, bone heath and uveitis.

The book has an easy format with each chapter having one or more clinicalvignettes at the start of the chapter. In addition each chapter outlines the learning objectives and key take home messages. At the end of each section a collection of cases to highlight important issues in the clinic are included. The colorful charts, pictures and tables make reading this book an easy task.

The authors are leading experts in their fields working at best practices centers globally to provide the reader with state-of-the-art information.

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Practical Hemostasis and Thrombosis 3rd Edition

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Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders.

  • Provides essential practical management for all those working in the field of hemostasis and thrombosis
  • Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies
  • Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders
  • Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading
  • Highlights controversial issues and provides advice for everyday questions encountered in the clinic

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Laparoscopic Liver, Pancreas, and Biliary Surgery: Textbook and Illustrated Video Atlas 1st Edition

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Laparoscopic Liver, Pancreas and Biliary Surgery: Textbook and Illustrated Video Atlas is the perfect learning tool for all surgeons managing patients requiring advanced liver, pancreas and biliary surgery minimally invasively.

This highly immersive text and video atlas will provide surgeons from trainee to advanced levels of practice, including, general surgeons, hepato-pacreatico-biliary surgeons, transplant surgeons and surgical oncologists, with a step-by-step, multi-media teaching atlas on performing laparoscopic liver surgery, anatomically correct, safely and effectively.

The atlas will teach the surgeons to perform anatomic liver resections of each liver segment expertly and logically, and will cover lobectomies, extended resections, advanced laparoscopic pancreas surgery (including Whipple) and other procedures. A special emphasis is placed on reproducibility of excellence in surgical technique.

Each video will be supported by outstanding illustrations for each technique and 3D renderings of the relevant anatomy. The educational step-by step high-definition videos teach everything you need to know, including critical aspects like patient positioning, port placement, dissection and much more.

Led by the pioneers in laparoscopic liver, pancreas and biliary surgery, Brice Gayet and Claudius Conrad, the textbook-chapters will be authored by world experts and will contain surgical tips and tricks garnered from their unique experiences, to improve care, management of complications, relevant society guidelines and excellence in oncologic care for patients with hepato-pancreato-biliary cancers.

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Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease 2012th Edition

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Although its underlying concept is a relatively simple one―the measurement of the human body and its parts―anthropometry employs a myriad of methods and instruments, and is useful for a variety of purposes, from understanding the impact of disease on individuals to tracking changes in populations over time. The first interdisciplinary reference on the subject, the Handbook of Anthropometry brings this wide-ranging field together: basic theory and highly specialized topics in normal and abnormal anthropometry in terms of health, disease prevention, and intervention. Over 140 self-contained chapters cover up-to-date indices, the latest studies on computerized methods, shape-capturing systems, and bioelectrical impedance, data concerning single tissues and whole-body variables, and reports from different areas of the world. Chapters feature helpful charts and illustrations, cross-references to related chapters are included, and key points are presented in bullet form for ease of comprehension. Together, the Handbook’s thirteen sections entail all major aspects of anthropometrical practice and research, including: Tools and techniques. Developmental stages, from fetus to elder. Genetic diseases, metabolic diseases, and cancer. Exercise and nutrition. Ethnic, cultural, and geographic populations. Special conditions and circumstances. The Handbook of Anthropometry is an invaluable addition to the reference libraries of a broad spectrum of health professionals, among them health scientists, physicians, physiologists, nutritionists, dieticians, nurses, public health researchers, epidemiologists, exercise physiologists, and physical therapists. It is also useful to college-level students and faculty in the health disciplines, as well as to policymakers and ergonomists.

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Ankylosing Spondylitis: The Facts (The Facts Series) Reprint Edition

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Ankylosing spondilitis is a chronic form of arthritis known to affect around 1 in 200 people (over 1 million sufferers in the USA alone). No cure has yet been found for the disease, however, early diagnosis and proper medical management can be important in reducing the risk of disability and deformity. Ankylosing spondilitis: the facts is the first mass market book to be published on this important disease. It provides clear and accessible information on treatment, diagnosis, genetic counselling, and daily life with this illness. Professor Khan is one of the leading experts in the world on AS, while also suffering from it. This combination of scientific knowledge and personal experience of a debilitating disorder results in a unique book which will prove invaluable for sufferers wishing to know more about their condition, and those that share their lives.

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Human Gross Anatomy: An Outline Text 1st Edition

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This text presents gross anatomy in an expanded outline format. Its conciseness and logical organization permit easy previewing of the subject matter before a lecture or laboratory as well as efficient learning and reviewing of the material before an examination. Notwithstanding its succinct style, the text’s coverage of gross anatomy is comprehensive and is written at a level of detail appropriate for the medical student.
The book begins with an introduction, setting forth basic principles and terminology that will serve the student throughout the remainder of the text. Overviews of the nervous, muscular, skeletal, and vascular systems are also included in the introduction. The main part of the text is organized in the following sequence: The Back; The Thorax; The Abdomen; The Perineum and Pelvis; The Head and Neck; The Upper Limb; and The Lower Limb. Clinical notes that highlight anatomy relevant to current medical practice appear throughout these chapters. Since each regional anatomy chapter is complete in itself, the order in which they are studied is optional.

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AIDS-Related Cancers and Their Treatment (Basic and Clinical Oncology) 1st Edition

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This book summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS.
Presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system.
Illustrates points with clear and easily read figures, tables, and flow charts!
Written to survey the magnitude of the impact HIV and AIDS have had on public health and oncology, AIDS-Related Cancers and Their Treatment

  • identifies types of cancer and gives evidence for their associations with immunosuppression
  • compares and contrasts AIDS-related cancer with non-HIV malignancies
  • investigates the pathogenesis of malignancy in HIV/AIDS patients
  • provides guidelines for recognizing possible symptoms and making accurate diagnoses
  • supplies algorithms for evaluating and staging patients at presentation
  • outlines potential problems and obstacles in caring for AIDS-related cancer patients
  • suggests optimal therapeutic approaches for the care of patients with AIDS and cancer
  • discusses prognostic factors in response to therapy and survival statistics
  • describes preliminary experience with emerging therapies and projects new approaches
  • advises how to enroll patients to participate in clinical trials of new therapies
  • considers the psychological impact on patients and their need for counseling and support
  • reviews access-to-care issues in AIDS and the community burden of this epidemic
  • provides information sources for both AIDS patients and their physicians
  • and more
    With contributions from nearly 25 clinicians and citing more than 1200 references to support and elaborate on text material, AIDS-Related Cancers and Their Treatment is a crucial reference for oncologists, immunologists, infectious disease specialists, hematologists, internists, microbiologists, virologists, epidemiologists, molecular and cell biologists, pathologists, and medical students in these disciplines.

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The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology 1st Edition

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Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease.

The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states.

Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section.  The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position.

  • Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota
  • Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition
  • Explores the relationship humans have with their microbiota, and its significance in human health and disease
  • Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease

Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

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Pathogenesis of Neurodegenerative Disorders (Contemporary Neuroscience) Softcover reprint of hardcover 1st ed. 2001 Edition

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As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor­ ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro­ mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa­ tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.

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