Handbook of Immunological Properties of Engineered Nanomaterials (Frontiers in Nanobiomedical Research) 1st Edition

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The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.

The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Readership: Researchers, academics, undergraduates and graduates in toxicology, immunotoxicology and nanomedicine, and industry (small and mid biotech companies and big pharmaceutical companies), as well as regulatory agencies (EPA, FDA) and physicians.

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Current Essentials of Surgery 1st Edition

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Essential coverage of surgery! In the popular one-disorder-per-page format, this pocket guide features bulleted, high-yield information on over 400 common surgical diagnoses. With key equations and formulae, a clinical pearl per page, plus references, this book truly is essential in critical care.

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Nephrology in 30 Days (In Thirty Days Series) 2nd Edition

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A fast, innovative way to learn the core principles and clinical entities associated with nephrology at the point of care

A Doody’s Core Title for 2015!

Nephrology in 30 Days enables you to quickly and easily attain a complete understanding of the basics of nephrology, allowing you to successfully diagnose and manage kidney disease and its associated complications. Designed to impart this knowledge in just thirty days, this unique self-instructional tool is perfect for medical students, physician assistants, medical residents, andnephrology fellows rotating on the clinical nephrology service elective. Now in full color, Nephrology in 30 Days is the most effective way to gain a solid understanding of acute and chronic kidney diseases, disturbances of fluid and electrolyte balance, and disorders of acid-base and mineral metabolism homeostasis–in the least amount of time possible.

Updated to include the latest research and advances, including:

  • New formulas for estimating glomerular filtration rate
  • The role of WNK kinases in distal tubular sodium and potassium handling
  • Revised hyponatremia guidelines
  • The use of vaptans for clinical use
  • Newly reported forms of metabolic acidosis
  • The role FGF-23 and Klotho play in phosphorus homeostasis
  • Concerns about the use of erythropoietic stimulating agents
  • Approaches to and classification of both chronic kidney disease and acute kidney injury
  • Discussion of urinalysis and urine microscopy in the evaluation of kidney disease
  • New forms of tubulointerstitial disease such as immunoglobulin G4 (IgG4)-related disease
  • The pathological classification of systemic lupus nephritis and other glomerular diseases
  • The mechanisms and causes of essential and secondary forms of hypertension

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Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach 1st Edition

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Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach is the first evidence-based reference text designed for the multidisciplinary team of medical professionals involved in the investigation, diagnosis, and management of patients with gastrointestinal cancer. Written and edited by leading international experts in the field it sets the standard in clinical practice for dealing with esophageal, gastric, intestinal, colonic, hepatobiliary, pancreatic, and other GI tumors.

The book is divided into twenty-five clinical chapters each addressing the specific cancers affecting the gastrointestinal tract. Each chapter is written by a team of authors, with each contributor specially chosen to represent a different role in the MDT. This multidisciplinary team approach reflects the current care of GI cancer patients and enables clinical decision making and patient management. All the chapters have been tried and tested in MDT meetings in leading cancer centers around the world.

Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach provides in-depth evidence-based knowledge and is well illustrated throughout with color photographs, line drawings, and diagrams. This authoritative and practical resource is an essential reference for the entire MDT including gastroenterologists, hepatologists, GI surgeons, medical oncologists, radiation therapists, interventional radiologists, pathologists, specialist nurses, and clinical scientists.

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Hypertension (Oxford Cardiology Library) 2nd Edition

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The management of hypertension varies considerably from clinician to clinician. This pocketbook is a concise and evidence-based summary of current understanding and practice, including the most up-to-date guidance from national bodies and their recommendations for hypertension care.

An essential tool for everyday use in managing hypertension, this book covers the different phases of investigation and definitive management, and aids clinical decision-making by collating all the relevant information and guidance in one easily accessible place.

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Mild Cognitive Impairment and Dementia: Definitions, Diagnosis, and Treatment (AACN Workshop Series) 1st Edition

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In 2011, National Institute on Aging and Alzheimer’s Association joint task forces released proposed criteria for Alzheimer’ disease diagnosis. These proposals included revisions to the nearly 30-year-old NINDS-ADRDA criteria for Alzheimer’s diagnosis and added criteria for diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer’s disease. The same year the American Psychiatric Association proposed new criteria for major and minor neurocognitive disorders (the entities previously known as dementia and mild cognitive impairment, respectively). These new criteria reflect the research and clinical advances in identifying mild cognitive impairment and offer new opportunities for prevention, treatment, and management of neurodegenerative conditions.

A major focus of this book is on the mild cognitive impairment prodrome of the common dementias. In addition to discussing the most common neurodegenerative conditions, many rare neurodegenerative conditions are highlighted. Most chapters include an autopsy-confirmed case presentation from the authors’ files. Following the case presentation, those chapters present current diagnostic criteria, epidemiology, neuropathology/neurophysiology, genetics, neuroimaging studies as relevant, associated clinical features, differential neuropsychological features and possible interventions for each disorder.

The pace of change in research and practice in the field of normal cognitive aging and dementia is increasing almost as fast as the median age of the population. The massive baby boom population bubble is currently entering the age of risk for neurodegenerative conditions. Neuropsychologists will play a major role in refining and applying these diagnoses, and in developing, testing, and refining interventions for these diagnoses, and in caring for this population. This book is intended to prepare neuropsychologists and others interested in neuropsychology to serve this fastest growing segment of our population.

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The Springer Index of Viruses (Springer Reference)

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The continuous growth of knowledege makes it very difficult for scientists to retrieve comprehensive and accurate data on viruses. The desired information is often dispersed in a variety of books, journals and online resources. This encyclopedia presents the latest facts about all known viruses in a standardized form created by hundreds of the world’s leading virologists.

Virus taxonomy represents the basic framework that allows an understanding of the complex evolutionary process that continuously takes place among viruses and their hosts. Each of the 300 taxonomically ordered chapters includes detailed information on individual genus members, historical events, the hosts they can affect (animal, man or plant), virion morphology, genome properties, replication strategy, properties of individual transcripts and proteins, sequence accession numbers, biological properties, diseases, recombinant vector constructs, vaccine strains, key references, as well as a high-resolution particle image and a drawing of the genome organization. Its high content of easily accessible detailed information makes this Encyclopedia an indispensable tool for both researchers and lecturers. The new edition includes the recent discoveries made in this field as well as new viruses which have been discovered.

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Osteoarthritic Joint Pain

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Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of every 100 people and significantly reduces the quality of life in affected individuals. The major symptoms are chronic pain, swelling and stiffness; severe, chronic joint pain is often the central factor that causes patients to seek medical attention. Within the affected joint, there is focal degradation and remodelling of articular cartilage, new bone formation (osteophytes) and mild synovitis.

Several mechanisms are thought to contribute to osteoarthritic joint pain. These include mild synovial inflammation, bone oedema, ligament stretching, osteophyte formation and cartilage-derived mediators. Changes in joint biomechanics and muscle strength also influence the severity and duration of joint pain in osteoarthritis. Within the nervous system, the relative contributions of peripheral afferent nociceptive fibres and central mechanisms remain to be defined, and there is limited information on the phenotype of sensory neurons in the OA joint. Importantly, there is no relation between clinical severity, as measured by radiographic changes, and the presence and severity of joint pain. Patients with severe joint pain may have normal joint architecture as determined by X-ray, whereas patients with considerable evidence of joint remodelling may not have significant joint pain. Treatments for osteoarthritic joint pain include non-steroidal anti-inflammatory compounds, exercise, corrective shoes and surgical intervention. There remains a critical need for improved control of joint pain in osteoarthritis.

This book brings together contributions from key investigators in the area of osteoarthritic joint pain.  It covers the clinical presentation of joint pain, the pathways involved in joint pain, osteoarthritis disease processes and pain, experimental models and pain control. The discussions provide insights into the nature of osteoarthritic joint pain, identify key studies needed to advance understanding of the problem, highlight possible intervention points and indicate future pathways towards a better treatment of osteoarthritic joint pain.

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Patient Safety: A Case-Based Comprehensive Guide 2014th Edition

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Despite the evolution and growing awareness of patient safety, many medical professionals are not a part of this important conversation.  Clinicians often believe they are too busy taking care of patients to adopt and implement patient safety initiatives and that acknowledging medical errors is an affront to their skills.

Patient Safety provides clinicians with a better understanding of the prevalence, causes and solutions for medical errors; bringing best practice principles to the bedside.  Written by experts from a variety of backgrounds, each chapter features an analysis of clinical cases based on the Root Cause Analysis (RCA) methodology, along with case-based discussions on various patient safety topics.  The systems and processes outlined in the book are general and broadly applicable to institutions of all sizes and structures.

The core ethic of medical professionals is to “do no harm”.  Patient Safety is a comprehensive resource for physicians, nurses and students, as well as healthcare leaders and administrators for identifying, solving and preventing medical error.

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Fructose, High Fructose Corn Syrup, Sucrose and Health (Nutrition and Health) 2014th Edition

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The metabolic and health effects of both nutritive and non-nutritive sweeteners are controversial, and subjects of intense scientific debate.  These potential effects span not only important scientific questions, but are also of great interest to media, the public and potentially even regulatory bodies. Fructose, High Fructose Corn Syrup, Sucrose and Health serves as a critical resource for practice-oriented physicians, integrative healthcare practitioners, academicians involved in the education of graduate students and post-doctoral fellows, and medical students, interns and residents, allied health professionals and nutrition researchers, registered dietitians and public  health professions who are actively involved in providing data-driven recommendations on the role of sucrose, HFCS, glucose, fructose and non-nutritive sweeteners in the health of their students, patients and clients.   Comprehensive chapters discuss the effects of both nutritive and non-nutritive sweeteners on appetite and food consumption as well as the physiologic and neurologic responses to sweetness.   Chapter authors are world class,  practice and research oriented nutrition authorities,  who provide practical, data-driven resources based upon the totality of the evidence to help the reader understand the basics of fructose, high fructose corn syrup and sucrose biochemistry and examine the consequences of acute and chronic consumption of these sweeteners in the diets of young children through to adolescence and adulthood.

 

Fructose, High Fructose Corn Syrup, Sucrose and Health fills a much needed gap in the literature and will serve the reader as the most authoritative resource in the field to date.

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