Merkel Cell Carcinoma

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Merkel Cell Carcinoma is one of the first comprehensive, single-source clinical texts on the subject. Although not as common as melanoma, Merkel cell carcinoma is not rare – and it is both more deadly than melanoma and increasing at an epidemic rate. The book is clinical in focus and emphasizes treatment of this poorly understood cancer. Contributing authors include dermatologists, surgical oncologists, radiation oncologists, and medical oncologists from the US and around the world.

Features:

· Comprehensive single-source clinical reference

· Treatment focus

· Written for practitioners, with emphasis on clinical relevance and quick retrieval of information

· Contributing authors represent all disciplines involved in treatment of Merkel cell carcinoma: dermatology, surgical oncology, radiation oncology, and medical oncology

· International in perspective, with contributors from US and abroad

·  Members of active Merkel Cell Carcinoma Multicenter Interest Group have authored some of the chapters

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Neighbourhood Structure and Health Promotion

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From the Back Cover

It has long been theorized that people living in poor areas have more health problems than their more advantaged peers. More recently, science has been testing this hypothesis, concentrating on the impact of the built environment on well-being and its contribution to health inequities.

Neighbourhood Structure and Health Promotion offers sociology-based theory and evidence-based findings so readers may better understand the effects of place on health choices, behaviour, and outcomes. This international volume analyzes the complex relationships among neighbourhood conditions and characteristics, people’s perceptions of where they live, and their everyday health lives, from eating habits and activity levels to smoking, drinking, and drug use. Chapters introduce innovative methods for measuring and monitoring links between place and health in terms of risks and resources, and employing objective and subjective data. Prospects for engaging neighbourhoods in prevention efforts, particularly involving young people, and policy implications for the future of health promotion and inequity reduction are discussed as well. Included in the coverage:

  • The spatiality of injustice: area effects on behaviour.
  • Qualitative and quantitative methods for assessing neighbourhood health resources.
  • The potential of GIS and GPS in the health sciences.
  • Green spaces and health: possibilities for research and policy.
  • School neighbourhoods and obesity prevention in youth.
  • Connecting gender, social environment, and health.

Neighbourhood Structure and Health Promotion advances the study of this increasingly critical topic, making it a valuable reference for researchers, practitioners, policy makers and advanced students in health, health promotion, social epidemiology, and urban planning.

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Phospholipases in Health and Disease (Advances in Biochemistry in Health and Disease)

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Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction.

Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.

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Pediatric Hypertension (Clinical Hypertension and Vascular Diseases) 3rd ed.

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From the Back Cover

Problem-based Approach to Gastroenterology and Hepatology 1st Edition

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Taking the problem-based approach, this text helps clinicians improve their diagnostic and therapeutic skills in a focused and practical manner. The cases included demonstrate the diversity of clinical practice in the specialty worldwide, and are divided into five major sections: Upper GI, Pancreato-Biliary, Liver, Small and Large Bowel, and Miscellaneous.

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Heart Valves: From Design to Clinical Implantation

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From the Back Cover

146650370X

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Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals.

Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics.

The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

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White Paper on Joint Replacement: Status of Hip and Knee Arthroplasty Care in Germany

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White Paper on Joint Replacement

This White Paper details the status of hip and knee arthroplasty care in Germany. Hip and knee replacements are amongst the most frequently performed procedures and usually become necessarily due to age-related wear of the joint, osteoarthritis and fractures of the femoral neck. In light of demographic change, demands with regard to standards of care and the procedures are likely to rise.

Contents

•             This White Paper contains information on indications, procedures, health economic aspects and the healthcare system stakeholders involved.

•             It portrays current developments with regard to the prevalence of hip and knee arthroplasty, the healthcare situation and quality of care within the chain of medical care.

•             This book is complemented by a chapter assessing the current situation from an expert perspective with contributions from renowned experts in the fields of science, medical technology and medical practice.

This book addresses people involved in shaping and representing the healthcare system from a variety of fields including medical professions, health insurances and health sciences as well as journalists and patient representatives.

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Coronary Magnetic Resonance Angiography

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In recent years, there has been increasing interest in the clinical applications of coronary angiography techniques. Coronary MRA can be instrumental in the evaluation of congenital coronary artery anomalies, however, the complexity of advanced MR pulse sequences and strategies may be overwhelming to many. Coronary MR Angiography demystifies the art of coronary MRA by providing a text in plain language with clearly illustrated imaging steps and protocols. Designed to bridge the gap between radiology and cardiology, it is written for physicians and scientists planning to incorporate this technique into their research or practice.

“This book presents a comprehensive account of the emerging role of MRI in the assessment of the human coronary arterial tree. André Duerinckx has gathered together physicians and scientists from North America, Europe and the UK who are experts in their field to discuss the topic in depth. … The authors deal well with a difficult and evolving topic. The discussions are up to date and complete … .” (Richard E. Slaughter, Australasian Radiology, Vol. 47 (3), 2003)

“Since the 1990s several groups worldwide have explored the potential of magnetic resonance to substitute conventional coronary angiography. One of the pioneers was Dr. André Duerinckx, who, in his current book … has brought together the experience and expertise of the different groups. … this well illustrated book gives an excellent overview of coronary MR angiography, and can be recommended for all those who are active in the field of cardiac imaging and for those interested in starting imaging in this very exciting domain.” (J. Bogaert, European Radiology, Vol. 13 (6), 2003)

“The book pleasantly surprised me in several ways. First, the book is easy to read. … Second, the book is well organized. … Finally, this book is balanced. … In summary, the book has a wealth of accessible, readable information about the technical aspects of coronary MR angiography and cardiac MR imaging. This will be a useful resource for anyone involved or interested in cardiac MR imaging at any level.” (Philip A. Araoz, Radiology, September, 2003)

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Person-Centred Therapy: 100 Key Points 2nd Edition

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Person-centred therapy, rooted in the experience and ideas of the eminent psychotherapist Carl Rogers, is widely practised in the UK and throughout the world. It has applications in health and social care, the voluntary sector and is relevant to work with people who are severely mentally and emotionally distressed. As well as being a valuable sourcebook and offering a comprehensive overview, this edition includes updated references and a new section on recent developments and advances.

The book begins with a consideration of the principles and philosophy underpinning person-centred therapy before moving to a comprehensive discussion of the classical theory upon which practice is based. Further areas of discussion include:

The model of the person, including the origins of mental and emotional distress

The process of constructive change

A review of revisions of and additions to person-centred theory

Child development, styles of processing and configurations of self

The quality of presence and working at relational depth

Criticisms of the approach are addressed and rebutted and the application of theory to practice is discussed. The new final section is concerned with advances and developments in theory and practice including:

Counselling for Depression

The Social Dimension to Person-Centred Therapy

Person-Centred Practice with People experiencing Severe and Enduring Distress and at the ‘Difficult Edge’

A Review of Research

Throughout the book, attention is drawn to the wider person-centred literature to which it is a valuable key.

Person-Centred Therapy will be of particular use to students, scholars and practitioners of person-centred therapy as well as to anyone who wants to know more about one of the major psychotherapeutic modalities.

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