A Beginner’s Guide to Targeted Cancer Treatments

The accessible guide to the principles behind new, more targeted drug treatments for cancer

Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner’s Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available.

Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years.

Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource:
* Offers the latest insights into cancer biology
* Provides a broad understanding of how targeted cancer treatments work
* Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells
* Helps readers feel confident discussing treatment options with colleagues and patients
* Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them
* Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc.
* Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

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Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways 1st Edition

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International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression

Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy.  With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development.

A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.

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Preparing for the Occupational Therapy National Board Exam: 45 Days and Counting 2nd Edition

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Each new print copy includes Navigate 2 Preferred Access that unlocks the full eBook and Navigate 2 TestPrep which offers practice exams with over 1,000 questions including detailed rationales.

Preparing for the Occupational Therapy National Board Exam: 45 Days and Counting, Second Edition is a comprehensive overview for occupational therapist students preparing to take the National Board for Certification in Occupational Therapy (NBCOT) exam. It utilizes a well-received health and wellness focus and includes tips and self-assessment forms to develop effective study habits. Unlike other OT examination review guides, this text chooses to provide a more structured and holistic approach, including a detailed calendar and plan of study for the 45 days leading up to the exam.

KEY FEATURES
Chapter outlines cover subject matter found throughout an OT curriculum, drawn from a lexicon taken from the Occupational Therapy Framework III (AOTA, 2014)
Each subject address the four domain areas according to the NBCOT examination
Workbook pages include specific references used in OT curricula to enable exploration of challenging or unfamiliar content
Self-study activities with answers are provided at the end of each chapter
Journaling section includes 3-4 questions with a reflective learning approach to help students identify areas of weakness and prioritize studying
Test taking strategies, exam preparation activities, and real life advice for repeating the exam

ABOUT THE EDITORS
The editors of this edition have the experience and credentials needed to ensure a structured, organized, and effective approach to review a large amount of material in a reasonable amount of time. Dr. Rosanne DiZazzo-Miller has been assisting students from across the country for many years on preparing for the board exam, while Dr. Fredrick Pociask has expertise in instructional design and delivery. Furthermore, all practice question content was reviewed and edited by our Item Writing Specialist – Dr. Sara Maher – who is a well-known and respected item-writer in health-science education. This ensures that students will be provided with continuous examples of NBCOT® style questions.

Instructor Resources
Classroom worksheets and study questions
Laboratory guides and learning activities
PowerPoint® presentations for each chapter

More than a study guide, this book can provide a course-ready capstone in addition to the resources and activities already incorporated into the text. Utilize this comprehensive resource in your program to help students study for the NBCOT exam in preparation for a high pass rate in addition to or in place of current methods.

Features & Benefits
Navigate 2 Preferred Access

Navigate 2 Preferred Access provides access to the eBook and features online test prep strategies including over 1,000 practice questions and enough practice clinical simulation test questions to provide over 5 practice tests that cover content throughout the four domains using the NBCOT Domain Specifications chart. Each exam question provides a key with rationale for correct and incorrect answers and references. Provide your students with this unique resource as a classroom text and/or study preparation guide.

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The Enteric Nervous System 1st Edition

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Covers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system

This book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract.

It includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits.

This new book is ideal for gastroenterologists (including trainees/fellows), clinical physiologists and educators. It is invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It also provides a valuable resource for undergraduate and graduate teaching.

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FACTS 101 : Studyguide for Cambridge Handbook of Psychology, Health and Medicine by Ayers, Susan

Never HIGHLIGHT a Book Again! Includes all testable terms, concepts, persons, places, and events. Cram101 Just the FACTS101 studyguides gives all of the outlines, highlights, and quizzes for your textbook with optional online comprehensive practice tests. Only Cram101 is Textbook Specific. Accompanies: 9780521605106. This item is printed on demand.

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Basic and Clinical Toxicology of Organophosphorus Compounds

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This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

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Straight Talk about Psychiatric Medications for Kids, Fourth Edition Fourth Edition

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Is medication the right choice for treating your child’s emotional or behavioral problems? How can you be confident that he or she has been properly diagnosed? What do you need to know to get the most benefits from medication treatment, with the least risk? From leading child psychiatrists Timothy Wilens and Paul Hammerness, this book has already empowered many tens of thousands of parents to make tough decisions and become active, informed managers of their children’s care. With clarity and compassion, it explains how medications work; their impact on kids’ emotions, personality, school performance, and health; the pros and cons of specific treatment options; and much more. In addition to parents, teachers and other school professionals will find this book an ideal reference.

New in the Fourth Edition:
Extensively revised to include the latest information about medications and their uses, the fourth edition is even more accessible, and includes pullouts, bulleted lists, and “take home points” highlighting critical facts.

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Hypoxia: Translation in Progress (Advances in Experimental Medicine and Biology) 1st ed

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The latest in a series of books from the International Hypoxia Symposia, this volume spans reviews on key topics in hypoxia, and abstracts from poster and oral presentations. The biannual International Hypoxia Symposia are dedicated to hosting the best basic scientific and clinical minds to focus on the integrative and translational biology of hypoxia. Long before ‘translational medicine’ was a catchphrase, the founders of the International Hypoxia Symposia brought together basic scientists, clinicians and physiologists to live, eat, ski, innovate and collaborate in the Canadian Rockies.

This collection of reviews and abstracts is divided into six sections, each covering new and important work relevant to a broad range of researchers interested in how humans adjust to hypoxia, whether on the top of Mt. Everest or in the pulmonary or cardiology clinic at low altitude. The sections include:

  • Epigenetic Variations in Hypoxia
    High Altitude Adaptation
  • Hypoxia and Sleep
  • Hypoxia and the Brain
  • Molecular Oxygen Sensing
  • Physiological Responses to Hypoxia

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Ambulatory Gynecology 1st ed. 2018 Edition

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There are approximately 55,000 practicing ob/gyns in the United States. The obstetrics and gynecology residency training authority (the Accreditation Council for Graduate Medical Education) has now pushed ambulatory primary and preventative care to the top of its list for residency training. Interest in the area of ambulatory gynecology is not just growing in the field of ob/gyn, however; family and primary care practitioners, emergency room physicians, and advance practice nurses all must know how to diagnose, manage, and treat gynecological conditions. Since office technology has expanded and decision-making has become increasingly complex, physicians need a guide through the endless list of treatment options for commonly presenting gynecologic disorders. Ambulatory Gynecology gives practitioners tools for diagnosis, investigation and management of these disorders, including decision-making algorithms. The text is evidence-based. From endocrine disorders to breast disease, preventative measures for osteoporosis to management of an abnormal pap smear, from adolescent gynecology to menopause, this book is crucial for office-based physicians to feel confident practicing in all areas of gynecology.

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