Basic and Clinical Toxicology of Organophosphorus Compounds

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This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

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Straight Talk about Psychiatric Medications for Kids, Fourth Edition Fourth Edition

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Is medication the right choice for treating your child’s emotional or behavioral problems? How can you be confident that he or she has been properly diagnosed? What do you need to know to get the most benefits from medication treatment, with the least risk? From leading child psychiatrists Timothy Wilens and Paul Hammerness, this book has already empowered many tens of thousands of parents to make tough decisions and become active, informed managers of their children’s care. With clarity and compassion, it explains how medications work; their impact on kids’ emotions, personality, school performance, and health; the pros and cons of specific treatment options; and much more. In addition to parents, teachers and other school professionals will find this book an ideal reference.

New in the Fourth Edition:
Extensively revised to include the latest information about medications and their uses, the fourth edition is even more accessible, and includes pullouts, bulleted lists, and “take home points” highlighting critical facts.

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Hypoxia: Translation in Progress (Advances in Experimental Medicine and Biology) 1st ed

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The latest in a series of books from the International Hypoxia Symposia, this volume spans reviews on key topics in hypoxia, and abstracts from poster and oral presentations. The biannual International Hypoxia Symposia are dedicated to hosting the best basic scientific and clinical minds to focus on the integrative and translational biology of hypoxia. Long before ‘translational medicine’ was a catchphrase, the founders of the International Hypoxia Symposia brought together basic scientists, clinicians and physiologists to live, eat, ski, innovate and collaborate in the Canadian Rockies.

This collection of reviews and abstracts is divided into six sections, each covering new and important work relevant to a broad range of researchers interested in how humans adjust to hypoxia, whether on the top of Mt. Everest or in the pulmonary or cardiology clinic at low altitude. The sections include:

  • Epigenetic Variations in Hypoxia
    High Altitude Adaptation
  • Hypoxia and Sleep
  • Hypoxia and the Brain
  • Molecular Oxygen Sensing
  • Physiological Responses to Hypoxia

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Ambulatory Gynecology 1st ed. 2018 Edition

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There are approximately 55,000 practicing ob/gyns in the United States. The obstetrics and gynecology residency training authority (the Accreditation Council for Graduate Medical Education) has now pushed ambulatory primary and preventative care to the top of its list for residency training. Interest in the area of ambulatory gynecology is not just growing in the field of ob/gyn, however; family and primary care practitioners, emergency room physicians, and advance practice nurses all must know how to diagnose, manage, and treat gynecological conditions. Since office technology has expanded and decision-making has become increasingly complex, physicians need a guide through the endless list of treatment options for commonly presenting gynecologic disorders. Ambulatory Gynecology gives practitioners tools for diagnosis, investigation and management of these disorders, including decision-making algorithms. The text is evidence-based. From endocrine disorders to breast disease, preventative measures for osteoporosis to management of an abnormal pap smear, from adolescent gynecology to menopause, this book is crucial for office-based physicians to feel confident practicing in all areas of gynecology.

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Integrin Targeting Systems for Tumor Diagnosis and Therapy (Methods in Pharmacology and Toxicology) 1st ed. 2018 Edition

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This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.

Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.

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Decision Making for Minimally Invasive Spine Surgery 1st Edition

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Decision Making for Minimally Invasive Spine Surgery provides the critical tools needed to determine exactly when, for whom, and why minimally invasive spine surgery (MISS) is a viable option.

Ten tightly focused chapters each begin with a decision making algorithm that explains how to ascertain if MISS will benefit the patient more than traditional open surgery. Following each algorithm, concise yet detailed information on the preoperative evaluation, surgical techniques, and possible outcomes helps the reader to formulate a clear surgical strategy. The book closes with an incisive analysis of radiosurgery, instrumentation systems, image guidance, and promising advances in MISS that will stimulate further discussion of this emerging area.

Features:

  • A realistic assessment of both the advantages and drawbacks of MISS by pioneers in the field
  • Evaluative algorithms allow readers to form rapid, fully informed treatment decisions
  • Intuitive organization by spinal region facilitates quick reference

Spine surgeons, residents, or fellows in orthopedic surgery or neurosurgery will refer to this easily accessible manual every time they consider performing a minimally invasive spine procedure.

This is an excellent book with no comparisons, useful for neurosurgeons, spine surgeons, and radiologists.–Doody’s

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Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects 1st ed. 2018 Edition

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This unique compilation focuses on a very curious organ, the ovary. There are still many unknown facts about the origins of ovarian tissue and ovarian cancer, and each chapter describes in detail the latest insights into the ovary from basic to clinical aspects. Expert authors reveal the most recent findings on ovariogenesis and ovarian carcinogenesis by shedding light on stem cell biology for the ovarian surface epithelial cells or primordial germ cells. Readers will greatly increase their understanding of the relevance of the cells that constitute the ovary, which is of vast significance in comprehending the occurrence mechanism of ovarian tissue and ovarian cancer. In this way the book covers a wide range of fields concerned with the ovary. This work benefits not only gynecologists and obstetricians, but also basic researchers in the field of stem cell biology and all clinicians who are involved in the management of fertility preservation or ovarian cancer.

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Advances in Microbiology, Infectious Diseases and Public Health: Volume 9 (Advances in Experimental Medicine and Biology) 1st ed. 2018 Edition

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This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention.

Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2016 Impact Factor: 1.881.

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Surgical Critical Care Therapy: A Clinically Oriented Practical Approach 1st ed. 2018 Edition

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This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in surgical critical care.  The book reviews up to date data regarding the management of common problems that arise in the Surgical Intensive Care Unit. The protocols, care bundles, guidelines and checklists that have been shown to improve process measures, and in certain circumstances, are discussed in detail. The text also discusses several well designed randomized prospective trials conducted recently that have altered the way we care for surgical patients with traumatic brain injury, hemorrhagic shock, acute respiratory distress syndrome, and sepsis.  This book provides the practicing physician with a clinically oriented practical approach to handle basic and complex issues in the Surgical Intensive Care Unit.

This text will serve as a very useful resource for physicians dealing with critically ill surgical patients. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.  All chapters are written by experts in their fields and include the most up to date scientific and clinical information. This text will become an invaluable resource for all graduating fellows and practicing physicians who are taking the surgical critical care board examinations.

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Oxidative Stress and Redox Signalling in Parkinson’s Disease (Issues in Toxicology) 1st Edition

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Parkinson’s Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis.
This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics.
Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

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