Category: Oncology

Nanoscale Insights into Ion-Beam Cancer Therapy 1st ed. 2017 Edition

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This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide.

The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact.

The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.

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Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease 1st ed. 2017 Edition

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Co-edited and written by an interdisciplinary team of experts in oncology and cardiology, this book is a clinically useful resource on these overlapping topics:

• Cardiac complications in patients receiving cancer therapy

• The treatment of cancer in patients with cardiovascular disease

• The treatment of cardiovascular disease in patients with cancer

When relevant to medical practice, epidemiology and basic science are also included in the discussion and each chapter is written by an oncologist and a cardiologist. Additionally, the chapters follow a similar format to make the book truly interdisciplinary, user-friendly, and clinically applicable to specialists and non-specialists who care for patients with both cancer and cardiovascular disease.

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Integrative Medicine for Breast Cancer: An Evidence-Based Assessment 1st ed. 2016 Edition

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This book is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. The growing list of CAM products that could interfere with surgery (anesthesia, bleeding, outcomes…) and/or conventional medicines is very large and is provided in each section of the book. Additionally, the list of dietary supplements that could be utilized to improve quality of life for breast cancer patients is also emphasized. The various sub-specialty groups in breast are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether the topic is prevention, treatment, or a specific side effect of treatment.

The practical nature of Integrative Medicine for Breast Cancer: An Evidence-Based Assessment cannot be overstated. Chapters include a general overview of the CAM agent, whether or not it has data in medicine and oncology, and a list of potential drug interactions and specific clinical scenarios where it can be utilized or discouraged in the specialty. Thus, this book will become the gold standard evidence based text for use in teaching, not only for the students interested in oncology and breast cancer, but for all current oncology health providers.

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Laparoscopic Colorectal Cancer Surgery: Operative Procedures Based on the Embryological Anatomy of the Fascial Composition 1st ed. 2017 Edition

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This unique guide describes colorectal surgery procedures using medical terminology and anatomical terms originating from embryology.

In the last decade, laparoscopic procedures in gastrointestinal surgery have been enhanced and their safety has significantly improved. With the number of cases of colorectal cancer surgery increasing and laparoscopic surgery no longer considered a specialized surgery, the recognition of the correct anatomy is vital in these procedures. Unfortunately, however, the understanding of clinical anatomy is frequently separate from that of basic surgical concepts. Initially, the dissecting layer should be presumed to derive from the fascial anatomy based on embryological recognition. Furthermore, the techniques currently being used by surgeons should be described in sufficient detail and the appropriate anatomical terms should always be used. In view of this, this valuable monograph benefits gastrointestinal surgeons and general surgeons who are involved in the treatment of colorectal cancer.

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Oncologic Imaging: Spine and Spinal Cord Tumors 1st ed. 2017 Edition

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This book is a detailed guide to image interpretation in patients with spine and spinal cord tumors that will enable clinicians and residents to improve their diagnostic abilities. The book opens by introducing basic concepts in the imaging of spinal tumors, namely the compartmental approach and the histologic basis for the different imaging appearances. These concepts are explained with the aid of representative cases and schematic illustrations. The second part of the book represents a “training step” in which various spinal tumors are described in detail, focusing on the imaging findings. Representative cases are presented with radiographic, CT, and MR images; in addition, schematic illustrations and pathologic or operative images are included in selected cases. The third part is a “practice step” describing tips for correct imaging diagnosis. Individual chapters in this part focus on incidence-, age-, location-, and imaging pattern-based approaches to bone, extradural, intradural extramedullary, intramedullary, and pediatric spinal tumors. The presented cases will enhance the reader’s understanding of the different tumor patterns and assist in solving diagnostic problems that may be encountered in daily practice.

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Breast Cancer: Recent Advances in Biology, Imaging and Therapeutics

This book considers breast cancer from many novel and exciting perspectives. New insights into the basic biology of breast cancer are discussed together with high throughput approaches to molecular profiling. Innovative strategies for diagnosis and imaging are presented as well as emerging perspectives on breast cancer treatment.

Each of the topics in this volume is addressed by respected experts in their fields and it is hoped that readers will be stimulated and challenged by the contents.

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Breast Cancer: From Biology to Medicine

This volume thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer.

The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1.
In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed.
This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

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Atlas of Procedures in Surgical Oncology with Critical, Evidence-based Commentary Notes (With DVD-ROM) Har/Dvdr Edition

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This unique book presents a series of concisely written technical notes on common procedures in surgical oncology. Each operation is illustrated with pictures framing precise technical points. The book is accompanied by a DVD-ROM that includes video clips of the procedures.

Written by top European experts, this volume will provide an invaluable resource for young surgical oncologists to familiarize with technical details, develop a critical approach and expand their surgical skills. It will also be a useful source of reference for medical oncologists, radiologists, radiotherapists and nurses, as well as final-year medical students.

Readership: Oncologists, surgeons, radiotherapists, surgical oncologists, nurses and final-year medical students

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Squamous cell Carcinoma: Molecular Therapeutic Targets 1st ed. 2017 Edition

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This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.

The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.

Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and  their therapeutic applications for targeted therapies based on clinical trials reported worldwide.

This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.

About the Author

Professor Saman Warnakulasuriya OBE has extensive experience in conducting international collaborative research projects including clinical trials and a strong expertise of managing Head and Neck cancers.  He has championed ways to relocate his clinical follow up studies and experimental data from the laboratory into the real-world. His contributions as the Director of World Health Organization Collaborating Centre for Oral Cancer has over a decade catalysed a global collaborative effort to improve adherence to high standards of clinical care in his speciality around the world.

His experimental studies have reported on clinical adjunctive aids and novel ways of stratifying patients at high risk and reported on several biomarkers for the prediction of risk of malignant transformation from precancer to cancer. He has published over 260 peer reviewed papers mostly on oral cancer and premalignancy and several systematic reviews and book chapters. He is the recipient of several key scientific awards as a distinguished scientist and for his distinguished service to King’s College London for over 25 years.

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Current Concepts in Endometrial Cancer 1st ed. 2017 Edition

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This book comprehensively covers endometrial carcinoma, a type of gynecological cancer that is often overlooked but of great interest. Although the incidence of the disease is rapidly increasing, both per se and as part of familial cancer syndromes, there is a great deal of controversy regarding its diagnosis, evaluation and management.
This book underlines the significance of endometrial carcinoma, highlights key prevention measures, charts its evaluation, and addresses the stage-by-stage management of this malignancy, with particular attention to the role of minimally invasive surgery. Further, it includes a chapter on future perspectives including robotics, targeted therapies and other developments in the offing.
Overall, the book provides a comprehensive guide to endometrial cancer, which if approached properly, can have an excellent prognosis, thus saving many lives and/or achieving substantially improved quality of life.>

About the Author

Dr. Ranu Patni is a prominent gynecologic oncologist with more than fifteen years of experience in ‘Gynecologic Oncology’. After postgraduate work in Obstetrics and Gynecology, her quest for clinical, surgical and academic excellence led her to constantly upgrade her skills through trainings from reputed international and national institutions, including King George V Hospital (Sydney, Australia) and Tata Memorial Hospital (Mumbai). She has been a pioneer in establishing the concept of ‘Gynecological Oncology’ and ‘Menopausal Medicine’ in the state of Rajasthan, India.
Her surgical skills are backed not only by a large number of gynecological cancer surgeries including those on many challenging endometrial cancer patients, but also by very competitive long-term results. She is well known for her age-appropriate approach to individual patients and routinely adopts evidence-based fertility preservation techniques and hormonal conservation measures.

She also has a keen interest in research and dissemination of knowledge among the medical fraternity as well as the public. She has organized and participated in numerous national and international conferences / workshops, contributed chapters to books of national repute, published papers in national and international journals, edited and peer-reviewed papers for prominent journals, is an active member of many academic societies and has been a Principal investigator in large multicentric clinical trials on ‘Postmenopausal Osteoporosis’.

A unique feature of Dr. Patni’s career is her passion for public health education. Over the past twenty years, she has repeatedly engaged in efforts to educate the public, especially women, about the preventive and therapeutic aspects of various health issues.

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