Estrogen Receptor and Breast Cancer: Celebrating the 60th Anniversary of the Discovery of ER

Estrogen Receptor and Breast Cancer: Celebrating the 60th Anniversary of the Discovery of ER

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The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Fast Facts: Prostate Cancer, 9th edition

Fast Facts: Prostate Cancer, 9th edition

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Prostate cancer is unusual among solid tumors in that the majority of affected men die with, rather than of, the disease. This presents many challenges to healthcare professionals and patients in terms of deciding if, when and how to intervene in order to control tumor growth and spread, thereby extending survival but without compromising quality of life.

This is the ninth edition of Fast Facts: Prostate Cancer since 1996, testament to the rapid changes in the field and the steadily improving outlook for patients.

This new edition provides many key updates:

– the Gleason grade grouping, which has valuable prognostic value

– nomograms to evaluate risk

– our rapidly expanding understanding of the genetics and underlying pathogenesis of prostate cancer and the development of genomic tests to help identify those at greatest risk of developing clinically significant disease

– the continuing debate about the role of PSA in the screening, detection and monitoring of prostate cancer

– advances in imaging techniques, particularly multiparametric MRI, which is improving the accuracy of biopsy and reducing the numbers of negative biopsies

– the roles of drugs, surgery and radiotherapy in the treatment of prostate cancer at different stages, and our ever-improving understanding of when and how best to intervene, aided by improving understanding of the risk factors for disease progression.

Primarily intended for primary care providers, specialist nurses, junior doctors and allied healthcare professionals, this highly readable resource provides a comprehensive overview of prostate cancer, enabling fully informed discussions with patients about this complex disease.

Atypical Breast Proliferative Lesions and Benign Breast Disease 1st ed. 2018 Edition

Atypical Breast Proliferative Lesions and Benign Breast Disease 1st ed. 2018 Edition

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Management of atypical breast lesions continues to evolve. There is considerable controversy as to whether these entities represent risk factors for future breast cancer or whether they are instead precursor lesions.  A better understanding of the prognostic and therapeutic implications of each of these lesions is important for assessing subsequent breast cancer risk.  Risk assessment tools are available for screening high risk patients and understanding the utility and limitations of these tools is important for all clinicians involved in the care of patients. There have been significant advances in breast cancer screening in the last several year including breast tomosynthesis, automated breast ultrasound, molecular imaging, as well as accelerated breast MRI protocols. This has raised the question: Do women at risk for breast cancer need additional breast cancer screening using these newer imaging modalities?  In addition, with these advances in imaging, can women with atypical proliferative lesions be observed rather than undergoing surgical excision as some suggest? The role of observation, surgical excision and even prophylactic mastectomy in women with atypical proliferative lesions continues to be debated; however there is data that can guide physicians in the management of these patients.  Pleomorphic Lobular carcinoma in-situ (PLCIS) is a distinct pathological entity within LCIS and there is no consensus regarding surgical margins or the need for adjuvant treatment to prevent recurrence.  Recently, ductal carcinoma in-situ (DCIS) has been the subject of much controversy: is it truly a cancer or is it instead a precursor lesion.  The traditional management of DCIS with lumpectomy and radiation is now being debated and recent data demonstrates that low grade DCIS can be managed with observation.  Clinical trials are now accruing patients with low and intermediate grade DCIS to observation and close surveillance, and not surgical excision.  Finally, new guidelines for chemoprevention with the use of tamoxifen and raloxifen for women with atypical proliferative lesions, LCIS, PLCIS, and DCIS are available and should be discussed as an option when guiding management of these patients.

This book will provide a comprehensive review of this field and will serve as a valuable resource for clinicians, general surgeons, breast surgeons and surgical oncologists, as well as researchers with an interest in the management of atypical breast lesions. The book will review new data about breast cancer, risk factors for breast cancer, pathological features unique to each entity, the characteristic findings on imaging, risk stratification for genetic testing, as well as the current evidence-based management of each of these breast lesions. Our text will provide assessment tools for risk prediction of breast cancer. We will provide data on the current imaging modalities, as well as advanced screening options available for diagnosis and following these patients.  Current management of many of these lesions continues to be controversial in regard to observation with close surveillance versus the need for surgical excision of these lesions based on future risk or whether these lesions are precursor lesion.  For ductal carcinoma in-situ, the debate continues in regards to whether this disease entity is a precursor lesion that can be managed with observation or hormonal therapy, or is DCIS cancer and treated with lumpectomy and radiation.  Several studies have been published where patients are managed with observation and treatment with hormonal therapy before surgical management. New trials have already begun accruing patients with low to intermediate grade DCIS where patients will be managed with observation versus hormonal therapy only.  Management of DCIS continues to evolve and current management will be discussed

This text will provide a concise but comprehensive summary of the current management of patients with atypical breast proliferative lesions and some benign breast lesions and will help guided management of these patients.  All chapters in this text will be written by experts in the field in each of these disease entities.  They will all include the most up to date research and clinical information to enhance our understanding and treatment of patients.

The Biology of Gastric Cancers

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The Biology of Gastric Cancers

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As someone who has spent nearly half his life wondering about the relationship between Helicobacter and gastric cancer, I find this textbook on the subject exciting and timely. In fact, I am not aware of any other volume that has been able to distil so much new knowledge into such a comprehensive account of a poorly understood field. Taking my own view, as a scientist placed in the middle of the spectrum between basic science and clinical medicine, I can see that the editors, Jim Fox, Andy Giraud, and Timothy Wang, provide a broad mix of expertise, which ensures that the subject is treated with the right balance. From clinicopathologic observations in humans, to epidemiology, through animal models, to molecular and cell biology, this team has hit the mark for most readers. Fox is a well-known leader in animal models with broad expertise. He pioneered the field with observations on Helicobacter species in animals, from the time when only one spiral gastric bac- rium was known, “Campylobacter pyloridis. ” Fox partners with Wang, whose team recently announced a dramatic advance in the field of carcinogenesis―the obser- tion that bone marrow–derived stem cells participate in the changes that become cancer. To this nice mix has been added Andy Giraud from my own country, who brings to the table some remarkable genetic models of gastric cancer based on alterations in the gp130/stat3-signaling pathway

Practical Management of Thyroid Cancer: A Multidisciplinary Approach 2nd ed. 2018 Edition

Practical Management of Thyroid Cancer: A Multidisciplinary Approach 2nd ed. 2018 Edition

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Written by a multidisciplinary team of experts involved in the development of standards and guidelines for its management in the USA, UK, Europe and Asia, the book contains succinct and knowledgeable summaries of the management of thyroid cancer. Every chapter describes a different aspect of care, and provides clear and detailed information about caring for patients with this group of tumors.

This is an invaluable reference to health care professionals, from primary to tertiary care, involved in the management of thyroid cancer such as clinical nurse specialists, clinical psychologists, family medicine practitioners, specialists in palliative care (especially for anaplastic thyroid cancers), geneticists and surgeons, endocrinologists, oncologists, pathologists, and radiologists.

Skin Care in Radiation Oncology: A Practical Guide 1st ed

Skin Care in Radiation Oncology: A Practical Guide 1st ed

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This book serves as a practical guide for the prevention and treatment of radiation dermatitis. Skin toxicity caused by radiation treatment is common among cancer patients and minimizing the frequency and severity of these reactions improves quality of life and prevents interruptions that can compromise local-regional control. Each chapter is devoted to a specific disease site, such as the head and neck, breast, gastrointestinal, genitourinary, gynecologic, and central nervous system. Pediatric malignancies and wound care for locally advanced cancers are also discussed. For each topic, the range and frequency of the observed skin reactions, factors influencing these reactions, the typical course of each reaction and its resolution, and the interventions used are presented. This book provides evidence where it exists for the specific interventions and an extensive illustration program depicts the various reactions and their response to treatment protocols. Skin Care in Radiation Oncology: A Practical Guide presents a framework for patient care in an era of advancing technology and systemic and targeted therapies and is a valuable resource for radiation oncologists, dermatologists, and residents.

Diffuse Gastric Cancer 1st ed. 2018 Edition

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Was: $79.99

Diffuse Gastric Cancer 1st ed. 2018 Edition

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We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible.

Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.

Perez & Brady’s Principles and Practice of Radiation Oncology (Perez and Bradys Principles and Practice of Radiation Oncology) Sixth Edition

Perez & Brady’s Principles and Practice of Radiation Oncology (Perez and Bradys Principles and Practice of Radiation Oncology) Sixth Edition

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Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. The book’s comprehensive scope and abundantly illustrated format provide you with better understanding of the natural history of cancer, the physical methods of radiation application, the effects of radiation on normal tissues, and the most judicious ways in which you can employ radiation therapy in patient care. Traditionally available as a printed textbook, now it comes with a completely revamped digital experience, powered by Inkling!
NEW to the Sixth Edition…
• Site-specific chapters include relevant background information on each tumor—including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results, and more.
• Over 1,400 full-color illustrations highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.
• Increased emphasis on new approaches and technologies improve your understanding of three-dimensional treatment planning, intensity-modulated radiotherapy, combined modality therapy, and particle therapy.
• Greater emphasis on palliative and supportive care reflects the role of radiation treatment in non-curative roles.
• New editors and contributors let you benefit from their decades of experience.
• Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into the text, and much more.

An Atlas of Gynecologic Oncology: Investigation and Surgery, Fourth Edition 4th Edition

An Atlas of Gynecologic Oncology: Investigation and Surgery, Fourth Edition 4th Edition

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The latest edition of An Atlas of Gynecologic Oncology continues its coverage of the innovative techniques in investigation and surgery on the brink of becoming established as part of the gynecologic surgeon’s repertoire, now including the exciting developments in uterine transplantation.

An Atlas of Gynecologic Oncology: Investigation and Surgery, Third Edition 3rd Edition

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Fully updated and revised by an international team of editors and contributors, the third edition of this best-selling book presents a full description of the investigative and surgical procedures carried out by the gynecologic oncologist. The superb artwork of Dee McLean and Joanna Cameron is continues, with over 400 illustrations, allowing an easy step by step breakdown of each procedure. An Atlas of Gynecologic Oncology, Third Edition covers the innovative techniques on the brink of becoming established as part of the gynecologic surgeon’s repertoire.

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