Immunology ⋆ Page 11 of 15 ⋆ eMEDICAL BOOKS

Immunotherapy for Pediatric Malignancies 1st ed. 2018 Edition

February 23, 2018

This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.

Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.

About the Author

Dr. Juliet Gray is an Associate Professor and Consultant in Paediatric Oncology at the University of Southampton, UK. She has a strong clinical and research interest in immunotherapy for neuroblastoma, with particular expertise in novel antibody therapies. She leads a translational laboratory research group within the Southampton Cancer Immunology Centre, and is an active member of the UK NCRI Neuroblastoma group and SIOP European Neuroblastoma Research Network (SIOPEN).

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Immune Mediated Diseases: From Theory to Therapy (Advances in Experimental Medicine and Biology)

December 31, 2017

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This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who were eager to share some of the academic and clinical enthusiasm that defines the IMD meetings. The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the world’s best immunologists and clinicians to Moscow.

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Immunology

Challenging Cases in Allergic and Immunologic Diseases of the Skin

November 26, 2017

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“The purpose is to provide a framework for diagnosing and managing complex immunological diseases of the skin. … The audience is dermatologists, and third year dermatology residents would find this book useful. … This is a useful reference for clinicians. I would recommend it to any dermatologist who sees patients. … This book will teach readers how to think, and the test format provides a more active way to learn the material.” (Patricia Wong, Doody’s Review Service, February, 2011)

From the Back Cover

Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin.

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Immunology

Immunotherapy for Pediatric Malignancies 1st ed. 2018 Edition

November 23, 2017

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About the Author

Aurélien Marabelle, is currently the Clinical Director of the Cancer Immunotherapy Program at Gustave Roussy Cancer Center in Villejuif, France. Dr Marabelle is an immunologist and a pediatric oncologist by training. His clinical practice is currently dedicated to Early Phase Clinical trials in Cancer Immunotherapy and his translational research is focused on mechanisms of action of immune targeted therapies. He works as a senior medical oncologist and an investigator in the Drug Development Department (DITEP) directed by Prof Jean-Charles Soria. He is coordinating a team focusing on cancer immunotherapy translational research projects in the INSERM U1015 lab directed by Prof Laurence Zitvogel. Dr Marabelle is a member of the European Society of Medical Oncology (ESMO), the American Association of Clinical Oncology (ASCO), the European Academy of Tumor Immunology (EATI) & the American Association of Cancer Research (AACR).

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Autoimmune Thrombocytopenia 1st ed

November 23, 2017

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This book provides a concise yet comprehensive summary of the current state of knowledge concerning the pathophysiology, differential diagnosis and treatment options that support day-to-day patient management. It reviews a variety of treatments including TOP-R antagonists, along with Syk inhibitor, which has recently proven to be effective, enabling readers to update and broaden their knowledge of the disease.

Covering topics ranging from basic science to clinical practice, Autoimmune Thrombocytopenia will appeal to a wide readership, from medical interns and residents to clinicians and hematologists, offering them a thought-provoking, instructive and informative collection of cutting-edge works. Accordingly, readers will gain an overview of the autoimmune and other causes of the disease, and the book will serve as a foundation for new research directions that further our understanding of the pathophysiology and development of diagnosis and treatment options.

About the Author

Editors:

Yoji Ishida: Iwate Medical University School of Medicine

Yoshiaki Tomiyama: Osaka University Hospital

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Immunology

Immunbiologie: Eine Einführung (Springer-Lehrbuch) (German Edition)

November 17, 2017

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Wie funktioniert die Immunantwort? Was sind Effektorreaktionen? Verständlich und kompakt führt Jürgen Neumann Studenten der Biologie, Medizin, Biomedizin und Biochemie in die Immunbiologie ein. Darüber hinaus geht er auf aktuelle Themen ein, wie z.B. Autoimmunität, Allergie und AIDS sowie wesentliche Prinzipien der Immunität von Invertebraten und prinzipielle Fragen nach der Steuerung von Immunantworten. Für alle wissenschaftlich Interessierten, die über elementare Kenntnisse in Biologie und Biochemie verfügen, ist dieses Buch eine ideale Einführung. Einprägsame Tafelbilder veranschaulichen den Lehrstoff und vermitteln die Zusammenhänge.

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Immunology

Vaccine Science and Immunization Guideline: A Practical Guide for Primary Care 1st ed

November 12, 2017

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This book is a comprehensive resource on vaccines and immunizations for primary care physicians, advanced practice providers, and trainees. We are now seeing a rise in measles and the potential for rises in other previously rare infectious diseases, significantly due to public and physician misconceptions and misinformation about vaccines. The text addresses this issue by consolidating historical and current advances in vaccine science from how vaccines are developed to CDC recommendations on how and when to administer them. Expert authors also address barriers to improving vaccination rates in the U.S. and offer evidence-based recommendations on overcoming those barriers. This is an essential guide for primary care physicians, family physicians, pediatricians, internists, residents, medical students, mid-level providers, and learners for understanding vaccines and improving preventative care for their patients.

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Immunology

MHC Class I Antigens In Malignant Cells: Immune Escape And Response To Immunotherapy (SpringerBriefs in Cancer Research)

November 7, 2017

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Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy.

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Immunology

MIF Family Cytokines in Innate Immunity and Homeostasis (Progress in Inflammation Research) 1st ed. 2017 Edition

November 7, 2017

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The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

About the Author

Richard Bucala, MD PhD; Professor of Medicine, Pathology, and Epidemiology & Public Health at Yale University, School of Medicine, New Haven, CT, USA Jürgen Bernhagen, PhD; Institute of Biochemistry and Molecular Cell Biology, Universitätsklinikum Aachen, RWTH Aachen, Germany

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Immunology

Neuroimmune Pharmacology 1st Edition

November 2, 2017

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The chapters contained in this volume show scientific relationships among historically separated fields. This allows a unique opportunity for scientists and students to gain broad knowledge in disparate fields of clinical medicine and biomedical research. Overall, the text integrates cutting-edge neuroscience, immunology, pharmacology, neurogenetics, neurogenesis, gene therapy, adjuvant therapy, proteomics, and magnetic resonance imaging. It is a rich harvest and readers will gain a perspective that has not been readily available. Exposure to such a wealth of ideas is bound to inspire readers to undertake new and productive research initiatives. In summary, this is a volume not to be put on the shelf as a reference, but to be read cover to cover by aspiring neuroscientists. Dr. Patrick L. McGeer Professor Emeritus Kinsmen Laboratory of Neurological Research, University of British Columbia This exciting new textbook, Neuroimmune Pharmacology, reflects the history and vision of the Society on NeuroImmune Pharmacology and of the Society s official publication, the Journal of Neuroimmune Pharmacology. All three represent deliberations arising from a relatively young, interdisciplinary, and dynamic field of research, which have major translational implications for neurodegenerative, neuroinflammatory, neuropsychiatric diseases, and infections of the nervous system. They all demonstrate the synergistic value of integrating the parts: Neuroscience, Immunology, and Pharmacology. The extraordinary accomplishment of Neuroimmune Pharmacology is its comprehensive nature. It will be enthusiastically welcomed by members of the Society and will serve as the definitive resource for all students and researchers interested in various topics that are so well covered in the book. Dr. Phillip K. Peterson President, Society on NeuroImmune Pharmacology Professor, Department of Medicine, University of Minnesota

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