Category: General Practice

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People with severe sleep apnea may struggle for breath all through the night, not breathing for as long as ninety seconds at a time during their sleep. This syndrome, which affects at least four percent of men and two percent of women, can cause daytime fatigue, traffic and work accidents, deteriorating cognitive abilities, and cardiovascular problems. Yet until now there has been no accessible discussion of the history, physiology, and risk factors of sleep apnea. In this book Peretz Lavie, an expert in sleep research, tells the complete story of sleep apnea for the first time.
The book provides:

• an explanation of the symptoms of sleep apnea, including the most important one, snoring;

• an up-to-date description of the risk factors;

• a clear explanation why sleep apnea causes cardiovascular problems;

• a discussion of children’s breathing disorders in sleep;

• advice on how to get a consultation and diagnosis;

• evaluations of the treatments currently available;

• practical recommendations on how to live with the syndrome;

• interviews with the key figures in sleep apnea research;

• and more.

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This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca²⁺ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

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Dermatological conditions are intimately related to stress. Stress can affect, reveal or even exacerbate a number of skin disorders, including alopecia, seborrheic dermatitis, psoriasis, atopic dermatitis, pruritus, herpes, lichen planus, rosacea and urticarial. On the other hand, the skin disease itself could induce a secondary stress for the patient, influencing his or her quality of life. There is increasing evidence that stress influences disease processes and contributes to inflammation through the modulating hypothalamicpituitary- adrenal axis – releasing neuropeptides, neurotrophins, lymphokines and other chemical mediators from nerve endings to dermal cells.

This is one of the first books published on this topic, focusing more on the basic science aspects of stress in dermatopathology (oxidants, antioxidants, and oxidative injury in dermatopathology, dermatopharmacology, and dermatotoxicology.) Most Psychodermatology texts adopt a practical approach to identify all types of Psychodermatology disorders, focusing on clinical treatment. This concise title offers a comprehensive and didactic approach to skin diseases caused or exacerbated by stress, as well as covers the immunology, role and effect of stress on skin disease, and quality of life in dermatology. In the current programs of medical residency in dermatology, little is taught about the relationship between stress and skin diseases and this book is an important tool for young dermatologists and psychodermatologists in training.

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