Oxidative Stress and Redox Signalling in Parkinson’s Disease (Issues in Toxicology) 1st Edition

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Parkinson’s Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis.
This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics.
Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

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Hypertension and Renal Organ Damage (Practical Case Studies in Hypertension Management) 1st ed. 2018 Edition

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TNM Classification of Malignant Tumours 8th Edition

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TNM Classification of Malignant Tumours eighth edition provides the latest, internationally agreed-upon standards to describe and categorize cancer stage.

  • Published in affiliation with the Union for International Cancer Control (UICC)
  • Arranged by anatomical region, this authoritative pocket sized guide contains many important updated organ-specific classifications
  • There are new classifications for p16 positive oropharyngeal carcinomas, carcinomas of the thymus, neuroendocrine tumours of the pancreas, and sarcomas
  • To facilitate the collection of stage data for cancer surveillance in low and middle income countries there are new sections on Essential TNM and Paediatric Cancer Stage
  • New colour presentation

Erratum

TNM Classification of Malignant Tumours, 8th edition is available as an app for iOS and Android. This Wiley app-book is developed by MedHand Mobile Libraries. Improve your performance with relevant, valid material which is accessed quickly and with minimal effort in the palm of your hand using MedHand’s patented technology.

Click here to buy online or to find out more

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Total Burn Care, 5e 5th Edition

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Recent advances in research have resulted in tremendous changes in burn management. Stay fully up to date with the new edition of Total Burn Care, by leading authority Dr. David N. Herndon. Detailed procedural guidelines and video clips walk you through every step of the process, from resuscitation through reconstruction and rehabilitation. Everyone on the burn care team, including general and plastic surgeons, intensivists, anesthestists, and nurses, will benefit from this integrated, multidisciplinary guide to safe and effective burn management.

    • Discusses infection control, early burn coverage, occupational physical exercise, respiratory therapy, and ventilator management.

 

  • Summarizes key points at the beginning of each chapter for quick reference.
  • Uses an integrated, team approach to help you meet the clinical, physical, psychological, and social needs of every patient.
    • Offers expert guidance on early reconstructive surgery and rehabilitation, with new content on improved surgical techniques.
    • Provides access to 15+ procedural operative videos and PowerPoint presentations on topics ranging from alopecia and anesthesia to radiation and treatment of infection – ideal for teaching and presenting.
    • Covers special populations such as elderly and pediatric patients, and includes a new chapter on burns in pregnancy.

 

  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

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Atlas of Common Pain Syndromes, 4e 4th Edition

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The first step in the effective management of patients in pain is making the correct diagnosis . . . and how todiagnose pain is what Waldman’s Atlas of Common Pain Syndromes, 4th Edition is all about.

Written to help practitioners care for their patients in pain, this top-selling text provides complete, concise, step-by-step visual guidance to help simplify the diagnosis and management of over 130 common pain syndromes. The user friendly, easy to reference head-to-toe format gives the practitioner a concise description of each pain syndrome along with full-color art, drawings, clinical photographs, and a full range of radiological and ultrasound images that will help simplify making the correct diagnosis.

    • Covers more than 130 common pain conditions with the concise information you need to make the correct diagnosis, making it a useful everyday reference in clinical practice.
    • Using a consistent, easy to follow visual format, each chapter covers one common pain syndrome beginning with the correct ICD-10 code and containing a clear description of the signs and symptoms of each painful condition as well as the tests, differential diagnosis, clinical pearls, and the most up-to-date treatment options.

 

  • Includes a “Side Effects and Complications” sections in every chapter that help you avoid potential pitfalls in diagnosis and treatment.
    • Features thoroughly updated chapters throughout, keeping you up to date when treating the painful conditions you’re most likely to encounter.
    • Includes 13 new chapters that give you the knowledge you need to diagnosis and treat these new common pain syndromes.
    • Contains dozens of new clearly labeled illustrations, tablesand radiologic and ultrasound images that enhance this visually focused reference, helping you make the diagnosis.

 

  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

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Oral Mucosa in Health and Disease: A Concise Handbook 1st ed

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Trauma Induced Coagulopathy 1st ed

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This text is aimed at defining the current concepts that define trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It will serve as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader will have full understanding of the tests that are used to study trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications are reviewed in detail.

Trauma Induced Coagulopathy will also be a valuable source for quick reference to the clinician that is faced with specific clinical challenges when managing coagulopathy.

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Diagnostic Methods for Cirrhosis and Portal Hypertension 1st ed. 2018 Edition

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In-Flight Medical Emergencies: A Practical Guide to Preparedness and Response 1st ed. 2018 Edition

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