Category: Clinical Skills

Antibiotics: Challenges, Mechanisms, Opportunities 1st Edition

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A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance

Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.

This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.

Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:

  • What are antibiotics?
  • Where do antibiotics come from?
  • How do antibiotics work?
  • Why do antibiotics stop working?
  • How should our limited inventory of effective antibiotics be addressed?

Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

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Advances in Clincal Cognitive Science: Formal Modeling of Processess and Symptoms

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Increasingly, contemporary quantitative cognitive science is appearing in mainstream clinical-science and clinical-practice journals, and many of the techniques under study hold promise for aiding individuals who have problems in living. The essays in this volume showcase fertile clinical applications of quantitative cognitive science in charting abnormalities among groups and individuals, and discuss ways in which readers can apply these techniques in their own research and potentially in clinical assessment and practice. The contributors are cognitive scientists who have formally modeled clinically relevant aspects of cognitive functioning or cognition-related symptoms among special populations, and clinical scientists who have adapted techniques of quantitative cognitive science to advance their clinical research and assessment.

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The Vaccine Court: The Dark Truth of America’s Vaccine Injury Compensation Program

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A hard look at the National Vaccine Injury Compensation Program and the families desperately trying to navigate their way through it.

The Vaccine Court looks at the mysterious and often unknown world of the National Vaccine Injury Compensation Program (NVICP), the only recourse for seeking compensation for those who have been injured by a vaccine. The NVICP, better known as the ”Vaccine Court,” however, is not without controversy.

Established by Congress as a direct result of the passage of the National Childhood Vaccine Injury Act of 1986, the NVICP was supposed to offer a no-fault alternative to the traditional injury claims filed in state or federal courts and was to provide quick, efficient, and fair compensation for those who have been injured by vaccines. The reality, however, is that many cases take several years or longer to complete and require tremendous commitment from families already pushed to the brink of bankruptcy caring for the vaccine-injured family member, only to discover that the end result is manipulated by the government in defense of the US vaccine policy.

Mr. Rohde looks into the inner workings of the US Federal Claims Court and the NVICP. He interviews families who have filed petitions and won compensation, families who have been denied compensation, and families still waiting for a decision. By highlighting the journeys of these families—their efforts to find attorneys willing to represent them, the filing of their petitions, and the subsequent mountain of paperwork, medical records, and other documents that span years—Mr. Rohde exposes the bitter truth behind the NVICP. Through his thoughtful interviews and fact-finding research, The Vaccine Court sheds light on how the NVICP has evolved into something far more treacherous than what Congress envisioned with the National Childhood Vaccine Injury Act in 1986.

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Fundamentals of Medical Practice Investigation 1st Edition

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Fundamentals of Medical Practice Investigation fills an important gap in the resources for criminal investigators. Appropriate for novice medical investigators as well as seasoned investigators looking to sharpen their skills, this book unites step-by-step fundamentals with up-to-date research reviews of critical issues in the field, including sexual misconduct, patient abuse, drug use among medical practitioners, and unethical or illegal prescription practices. An essential tool for law enforcement and other criminal justice professionals, Fundamentals of Medical Practice Investigation will improve the quality of all types of medical investigation.

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Optimizing Your Capacity to Care: A Systems Approach to Hospital and Population Health Management 1st Edition

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Our nation’s capacity to care is becoming increasingly stressed as an aging and increasingly unhealthy population collides with a relative reduction in the numbers of clinicians and ever-tightening financial resources. If even the mildest of future-state predictions are to be believed, we need a significant restructuring of our entire healthcare system and its total Capacity to Care, such that we can simultaneously improve care capacity, cost, quality, accessibility, and resource gratification.

Optimizing Your Capacity to Care: A Systems Approach to Hospital and Population Health Management provides comprehensive guidance to a new way to optimize and manage community-wide Care Capacity via a unique, holistic approach to healthcare operations. Through clear examples and actual project results, the book demonstrates the outcomes of a systems-level way of thinking about a community’s Capacity to Care that incorporates and integrates the full spectrum of available clinical and communal resources into the care of patients, including hospitals, physicians, emergency departments, surgical services, local churches, civic organizations, pharmacies, and volunteers.

The book details operational models for each major department of the hospital and a fully integrated communal resource pool to demonstrate how the optimization of capacity, resource utilization, cost, and clinical outcomes can be attained. And by providing healthcare leaders with a deeper understanding of key elements missing from the most common process improvement methodologies and approaches, this book offers fresh perspectives and bold alternatives for hospitals, health systems, and entire communities.

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Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis (Chapman & Hall/CRC Biostatistics Series)

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Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. FDA and National Cancer Institute), and the pharmaceutical industry share their extensive experiences in cancer clinical trials and present examples taken from actual trials.

The book covers topics that are often perplexing and sometimes controversial in cancer clinical trials. Most of the issues addressed are also important for clinical trials in other settings. After discussing general topics, the book focuses on aspects of early and late phase clinical trials. It also explores personalized medicine, including biomarker-based clinical trials, adaptive clinical trial designs, and dynamic treatment regimes.

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The Primary FRCA Structured Oral Exam Guide 1, Second Edition (MasterPass) 2nd Edition

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The Primary FRCA Structured Oral Examination Study Guide 1 is the definitive revision aid to the Primary FRCA structured oral examination. This second edition is revised and updated in line with the new Royal College of Anaesthetists ‘Guide to the Primary FRCA’, with over 20 new topics to reflect changes to the RCoA’s model questions and major revisions to graphs, diagrams and many of the pre-existing sections.

Packed with new guidelines and current hot topics, this first volume covers physiology and physics. The nearly 50 physiology topics covered include lung function, hypoxia, acid–base balance, pain pathways, oxygen transport, cerebral blood flow and more. Nearly 30 physics topics are covered including gas laws, oxygen measurement, cardiac output monitoring, safety features of the anaesthetic machine, resuscitation bags and valves, depth of anaesthesia monitoring and more. The second edition of this hugely popular book is improved in clarity and content but stays true to the pragmatic approach adopted by the authors in the first edition.

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Smart Use of State Public Health Data for Health Disparity Assessment 1st Edition

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Health services are often fragmented along organizational lines with limited communication among the public health–related programs or organizations, such as mental health, social services, and public health services. This can result in disjointed decision making without necessary data and knowledge, organizational fragmentation, and disparate knowledge development across the full array of public health needs. When new questions or challenges arise that require collaboration, individual public health practitioners (e.g., surveillance specialists and epidemiologists) often do not have the time and energy to spend on them.

Smart Use of State Public Health Data for Health Disparity Assessment promotes data integration to aid crosscutting program collaboration. It explains how to maximize the use of various datasets from state health departments for assessing health disparity and for disease prevention. The authors offer practical advice on state public health data use, their strengths and weaknesses, data management insight, and lessons learned. They propose a bottom-up approach for building an integrated public health data warehouse that includes localized public health data.

The book is divided into three sections: Section I has seven chapters devoted to knowledge and skill preparations for recognizing disparity issues and integrating and analyzing local public health data. Section II provides a systematic surveillance effort by linking census tract poverty to other health disparity dimensions. Section III provides in-depth studies related to Sections I and II. All data used in the book have been geocoded to the census tract level, making it possible to go more local, even down to the neighborhood level.

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Sensory Perceptual Issues in Autism and Asperger Syndrome: Different Sensory Experiences – Different Perceptual Worlds Paperback – June 15, 2003

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The ability to perceive accurately stimuli in the environment is basic to many areas of academic, communicative and social functioning. Although people with autism live in the same physical world and deal with the same `raw material’ their perceptual world turns out strikingly different from that of non-autistic people. It is widely reported that autistic people have `unusual’ sensory perceptual experiences that may involve hypo- and hypersensitivity, fluctuation between different `volumes’ of perception and difficulty interpreting a sense.

In this book, Olga Bogdashina attempts to define the role of sensory perceptual problems in autism identified by autistic individuals themselves. Often ignored by many professionals, this is one of the main problems highlighted by autistic individuals. This book singles out possible patterns of sensory experiences in autism and the cognitive differences caused by them. The final chapters are devoted to assessment and intervention issues with practical recommendations for selecting appropriate methods and techniques to eliminate the problems and enhance the strengths.

Sensory Perceptual Issues in Autism and Asperger Syndrome is vital to teachers and other professionals working with autistic individuals to fully comprehend sensory perceptual differences in autism. This book will help readers select appropriate methods for dealing with autistic individuals. In addition, parents of autistic individuals and autistic individual themselves will find the information will enable them to initiate relevant strategies and environmental changes to facilitate more effective learning.

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Personalized Medicine: Promises and Pitfalls 1st Edition

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Personalized Medicine: Promises and Pitfalls broadly explores the tailoring of medical treatment to a patient’s characteristics, needs, and preferences during all stages of care, including prevention, diagnosis, treatment, and follow-up.

The book’s goal is to explain the science behind personalized medicine, what impact it may have on specific diseases, and some of the repercussions of a personalized medical approach on our medical institutions.

Novel personalized therapeutic treatments and their scientific basis are discussed by covering topics as diverse as genomics, proteomics, epigenetics, integrative medicine, stem cells, and the factors that influence personal health.

A personalized medical system also requires patient involvement in developing a healthy lifestyle, and so this book touches on topics such as the individual’s family history, present and past lifestyle, nutrition, exercise levels, and stress factors.

By explaining these broad topics in personalized medicine and the science behind them, we discover how personalized medicine can have a positive impact on an individual’s health.

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