Category: Clinical Skills

Oxford Guide to the Treatment of Mental Contamination (Oxford Guides to Cognitive Behavioural Therapy) 1st Edition

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A fear of contamination drives the most common manifestation of obsessive compulsive disorders(OCD), compulsive washing. OCD is a distressing anxiety disorder that affects 1-2 percent of the population and can be disabling. Intense and complex forms of the disorder benefit from advanced analyses of contamination and its treatment.

This book, part of a series on modern psychological treatments published by OUP, provides a detailed account of the nature and causes of the various forms of a fear of contamination and their consequences. Methods of treatment are described and fully illustrated by case histories. The inclusion of original analyses and explanations of a newly recognised form of the fear, mental contamination, is an important feature of the book and will enable therapists to expand their ability to assess and treat the abnormal fears of contamination.

Written by clinicians with extensive experience, this volume is valuable for all clinical psychologists and psychotherapists with an interest in OCD

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Protein Expression in Down Syndrome Brain (Springer Medicine) 2001st Edition

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When we worked on Down Syndrome brain in the past we have been focus­ ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz­ ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi­ cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under­ standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons. In addition, evaluation of the nature of the neuronal deficits in terms of neuro­ transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex.

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Bayesian Designs for Phase I–II Clinical Trials (Chapman & Hall/CRC Biostatistics Series) 1st Edition

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Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources.

Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.

The first two chapters minimize the technical language to make them accessible to non-statisticians. These chapters discuss the severe drawbacks of the conventional paradigm used for early-phase clinical trials and explain the phase I–II paradigm for optimizing dose, or more general treatment regimes, based on both efficacy and toxicity. The remainder of the book covers a wide variety of clinical trial methodologies, including designs to optimize the dose pair of a two-drug combination, jointly optimize dose and schedule, identify optimal personalized doses, optimize novel molecularly targeted agents, and choose doses in two treatment cycles.

Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

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Case History and Data Interpretation in Medical Practice: Case Histories, Data Interpretation, Pedigree, Spirometry

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This book has incorporated the techniques for a logical and accurate interpretation of the clinical information according to the modern examination system. The first edition of this book was published with the intention of helping students learn the basics of data interpretation and practice by themselves. Its huge popularity and wide acceptance among students has encouraged the author to upgrade the book and bring out this new edition enriched with new cases and pictures of a variety of clinical conditions. 100 new clinical cases have been added. The text contains variety in clinical setup, and the amount of data provided in each setup. Includes data on cardiac catheterization and a whole new chapter on pictorial diagnosis which contains 100 clinical pictures. Various modifications have been made in the book according to various innovative suggestions made by teachers and students. Incorporates many long and short questions with proper investigations, largely based on the real cases. Answers are given with brief short notes of the specific problems, so that the reader can get some idea without going through a big textbook. The book will help increase a doctors competence, and skill in diagnosing a particular disease, formulating specific investigations, and proper management. TABLE OF CONTENTS: I. Case History and Data Interpretation, II. Data Interpretation of Cardiac Catheter, III. Family Tree (Pedigree), IV. Spirometry, V. Pictures of Multiple Diseases.

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Allergies Sourcebook: Basic Consumer Health Information

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“Provides basic consumer health information about the development of allergies in children and adults; foods, food additives, airborne allergens, chemicals, and environmental triggers of allergic reactions; and facts about allergy testing, treatment options, prevention tips, and coping strategies. Includes index, glossary of related terms, and other resources”–

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Clinical Trials with Missing Data: A Guide for Practitioners (Statistics in Practice) 1st Edition

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This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable.

The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively.

The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.

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CPHIMS Review Guide, Third Edition

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Whether you’re taking the CPHIMS exam, or simply want the most current and comprehensive overview in healthcare information and management systems today – this completely revised and updated third edition has it all. But for those preparing for the CPHIMS exam, this book is an ideal study partner. The content reflects the exam content outline covering healthcare and technology environments; systems analysis, design, selection, implementation, support, maintenance, testing, evaluation, privacy and security; and administration leadership management. Candidates can challenge themselves with the sample multiple choice questions at the end of the book.

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Communicable Diseases: A Global Perspective (Modular Texts Series) 5th Edition

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Completely updated and revised, and now published in its fifth edition with an integrated eBook, this prestigious and best-selling text has continued to provide an essential overview of the subject for over 20 years. A comprehensive yet synoptic account of diseases and their modes of transmission, the book covers epidemiology, control strategies, notifications and regulations, as well as an overview of the major diseases established, new and emerging.

– Concise so that key information can be found at a glance
– Numerous clear diagrams, bullet points and tables for rapid review and learning
– Integrated eBook for online or download to a desktop, tablet or smartphone

Communicable Diseases continues to provide an essential resource for all those in public health and medical science, and for healthcare workers needing a comprehensive yet concise practical text.

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Diabetic Foot: A Clinical Atlas 1st Edition

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Over 120 million people worldwide suffer from diabetes and 85 percent of diabetes-related amputations are preceded by foot ulcer. Understanding the causes of this catastrophe, identifying the sufferers and those at high risk and developing effective preventive strategies and remedies for its consequences has become a major preoccupation with diabetologists in recent years. Diabetic Foot: A Clinical Atlas is primarily devoted to clinical matters with illustrations and case reports depicting varied diabetic foot problems. Divided into eight sections, the book contains 53 case studies and over 600 clinical photographs, as well as a detailed bibliography for further reading.

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PART I http://upsto.re/vSUHU22

PART II http://upsto.re/vSUeVnX

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