Category: Clinical Skills

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Thanks to an increasing life expectancy of our populations the number of elderly persons is steadily growing and will continue to do so. Among these, the rate of persons with illnesses and degenerative diseases is significant. The prevalence of osteoporosis is especially high in elderly women and leads to typical fracture patterns. Hip fractures, proximal humerus fractures, distal radius fractures and fractures of the vertebral column are the most common. In the last decade, we are confronted with a sharp increase of fragility fractures of the pelvis.

Until now, there is no consensus on how to identify and classify these lesions and there are no guidelines for treatment and after treatment. In particular, there is no common view on which patients need an operative treatment and which technique of osteosynthesis should be used.

This book fills the gap in available literature and gives a state of the art guide to the treatment of fragility fractures of the pelvis. With the sharp increase of these fractures and the lacking consensus, Fragility Fractures of the Pelvis will become indispensable for the physicians who take care of elderly patients with this pathology. Written by a team of expert opinion leaders, the aim of this book is to contribute to the scientific discussion in this area and to help provide the optimal care for these patients.

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About the Author

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Long-established as the gold standard in the field, Casarett and Doull’s Toxicology is now available in a new Sixth Edition that equips you with an unsurpassed treatment of modern toxicology, including the principles, concepts, mechanisms, and modes of thought that are the foundation of the discipline.

Comprehensive and completely up to date, the new edition of Casarett and Doull’s Toxicology remains your best source for the latest breakthroughs in this fast-changing field.
* The new edition of this gold standard in the field is more valuable than ever
* Detailed coverage of the advances in molecular biology and pharmacogenetics
* Expanded coverage of risk assessment
* Coverage of online references, in addition to traditional print journal and review articles
* New chapter outlines
* New 2-color design

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A comprehensive volume written by leading researchers, clinicians, and educators in the field, Clinical Management of Children With Cochlear Implants, Second Edition offers a guide for practitioners, instructors, and students. The book builds on over thirty-five years of collective experience in pediatric cochlear implantation and addresses contemporary practices. The authors share their expertise in such disciplines as otolaryngology, pediatrics, audiology, speech-language pathology, habilitation, education, electrophysiology, psychology, and clinical research. Although many of the chapters from the first edition remain relevant today, the field continues to evolve with advancements in technology, expanding indications, and patient demographics. The second edition reflects these changes with new topics and expanded updates, presenting up-to-date research findings with implications for clinical management of the pediatric implant population.
New to this edition:

• New chapters on neurocognitive assessment, dual language learning, early literacy, family-centered habilitation, and development of evidence-based programs
• Expanded chapters on device programming, education, and auditory brainstem implants
• Updates in research and clinical practices in assessment and management

Expert contributors include: Frank R. Lin, Patricia A. Roush, John K. Niparko, Richard C. Seewald, Laurie S. Eisenberg, Margaret E. Winter, Kristina Celani Rousso, Ksenia A. Aaron, Elina Kari, Rick A. Friedman, Jace Wolfe, Erin C. Schafer, Ruth Litovsky , Carolyn J. Brown, Rachel Anna Scheperle, Viral D. Tejani, Eun Kyung Jeon, Shruti Balvalli Deshpande, Paul J. Abbas, Karen Iler Kirk, René H. Gifford, Kristin Uhler, Sigfrid D. Soli, Yun Zheng, Dianne Hammes Ganguly, Sophie E. Ambrose, Catherine Cronin Carotta, Liat Kishon-Rabin, Osnat Segal, Carren J. Stika, John F. Knutson, William G. Kronenberger, David B. Pisoni, Sharon L. Cushing, Blake C. Papsin, Yevgeniy R. Semenov, Howard W. Francis, Jane Freutel, Mary D. McGinnis, Jill A. Muhs, Debra Kay Schrader, Vicki L. Reynolds, W. Michael Douglas, Jean L. DesJardinRachel Umans and Dana L. Suskind. Karen C. Johnson, Susan Wiley, Jareen Meinzen-Derr, Holly F.B. Teagle, Lisa R. Park, Shuman He, Carlton J. Zdanski, Craig A. Buchman, Laurel M. Fisher, Amy S. Martinez, Jamie L. Glater, and Robert V. Shannon

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This book discusses key aspects of platelet function in the regulation of hemostasis and thrombosis. It covers topics ranging from the platelet cytoskeleton to the antiphospholipid-antibody syndrome. Among the many highlights of the book is the section on von Willebrand’s disease, a group of quantitative and qualitative abnormalities of von Willebrand factor. These abnormalities are the most common causes of inherited bleeding disorders, with a prevalence of up to 1 percent of the population. The defect in primary hemostasis results from a failure of platelet adhesion at the site of vascular damage. New ways of classifying von Willebrand’s disease according to its pathophysiologic characteristics are discussed by Sadler. Lopez and colleagues review the glycoprotein Ib/IX/V complex, a group of proteins on the platelet surface that make it possible for the platelet to bind to matrix-bound von Willebrand factor. The authors point out that the Ib/IX/V complex forms a receptor with unique functions — platelet adhesion and activation — and they discuss how the binding of von Willebrand factor to the complex initiates platelet activation.

Du lucidly describes the dialogue between extracellular and intracellular compartments of the platelet. Some signaling pathways in the platelet are initiated with the binding of an agonist to a platelet membrane receptor; this causes the receptor to increase its affinity and thereby acquire the ability to respond to ligands such as fibrinogen and von Willebrand factor. Other signaling pathways are initiated after the ligation and clustering of integrins (transmembrane proteins that allow the attachment of cells to the extracellular matrix). The binding of ligands to receptors for platelet-derived growth factor or the thrombin receptor results in platelet spreading, secretion from intracellular granules, the availability of platelet membrane phospholipoprotein for coagulation, and clot retraction. Fox and Meyer, in discussing the platelet cytoskeleton, emphasize the similarity of cytoskeletal reorganizations in platelets to those in other cells, and Campbell and associates describe the background and current status of phosphoinositide-derived second-messenger molecules in platelet activation.

The important platelet membrane glycoprotein CD36 is discussed by Thorne and colleagues. Discrete functions of CD36 have been elucidated in lipid metabolism, fatty-acid transport, cell adhesion, angiogenesis, inflammation, and activation of transforming growth factor (beta). A deficiency of CD36 has been associated with hereditary hypertrophic cardiomyopathy.

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About the Author

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From the Back Cover