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Clark’s Essential Guide to Clinical Ultrasound (Clark’s Companion Essential Guides) 1st Edition

Clark’s Essential Guide to Clinical Ultrasound (Clark’s Companion Essential Guides) 1st Edition

This easy-to-understand pocketbook in the highly respected Clark’s stable of diagnostic imaging texts is an invaluable tool for students, sonographers and other ultrasound practitioners, providing practical guidance on clinical ultrasound procedures, summarising current relevant literature and professional body guidelines.

The content is arranged by anatomical system and organ for ease of reference, with each section comprising a short introduction, the indications for the procedure, patient preparation, the imaging procedure itself, along with an image analysis, supported throughout by positioning photographs and clinical images.

Clark’s Essential Guide to Clinical Ultrasound is ideal for all users of clinical ultrasound at both undergraduate and postgraduate level and will also provide a convenient distillation of the latest best practice and guidelines for sonographers, midwives, vascular technologists, ECG technologists, medical doctors, sports injury specialists, paramedics, and other health professionals.

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Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models 1st Edition

Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models 1st Edition

How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes.

Key Features:

  • Full-color illustration program with diagrams to help illuminate the concepts
  • Enables the reader to apply modeling and theory to the biological processes
  • Further Reading for each chapter
  • High-quality figures available for instructors to download

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Clinical Integration: Surgery

Clinical Integration: Surgery

Clinical Integration: Surgery

This medical book shows readers the logical connections between patient history, examination findings, investigation results, management rationale and their underlying mechanisms. Readers learn to understand the “why and how” behind the diagnosis, investigation and management of common clinical problems.

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The book takes a system-based approach to cover common surgical cases, from aortic stenosis to varicose veins, via diverticulitis and pressure ulcers.

Every case uses a consistent format to:

  • highlight the key elements of the history, examination and investigations
  • ­offer a guide to management options
  • ­provide rapid access to important facts

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Cancer Immunotherapy Principles and Practice, Second Edition

Cancer Immunotherapy Principles and Practice, Second Edition

Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer.

The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field.

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Placental-Fetal Growth Restriction 1st Edition

Placental-Fetal Growth Restriction 1st Edition

Placental-Fetal Growth Restriction 1st Edition

Master the effective evaluation, analysis and management of placental-fetal growth restriction (PFGR), developing strategies to reduce the risk of perinatal mortality and morbidity in patients worldwide. Extensively researched by international experts, this manual provides practitioners with a detailed, hands-on approach to the practical ‘pearls’ for direct patient management.

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This authoritative volume advises on matters such as the correct evaluation and management of high-risk patients in danger of PFGR through to delivery. Extensive and wide-ranging, this book is an invaluable companion to the developing research interest and clinical applications in PFGR, including developmental outcomes in early childhood. Featuring a critical evaluation of a variety of abnormal conditions, such as fetal hypoxia and extreme prematurity, which are clearly displayed through extensive illustrations, this essential toolkit ensures that practitioners at all levels can effectively limit adverse outcome and reach the correct diagnosis.

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Oxford Handbook of Operative Surgery (Oxford Medical Handbooks) – 3rd Edition

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Oxford Handbook of Operative Surgery (Oxford Medical Handbooks) – 3rd Edition

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For its third edition, this handbook has been fully revised and rewritten for the renowned Oxford Medical Handbook series. Including comprehensive coverage of all common surgical specialties and operations, it fully integrates practical advice on pre-operative procedure, equipment, step-by step surgical procedures, common techniques, and tips and tricks from over thirty experienced specialist surgeons.

With over three hundred detailed practical diagrams and images to assist your understanding and packed with step-by-step, concise, and clear expert advice, you can be confident that this handbook will be your essential guide to all aspects of operative surgery.

Providing an overview of modern operative surgical practice the Oxford Handbook of Operative Surgery will enable all surgeons, whether they are just starting out or posessing many years’ experience, to prepare fully and be confident in observing, assisting or performing across the wide variety of surgical operations. Fully up to date and reflecting current practice and guidelines, it provides an essential complement to the highly successful Oxford Handbook of Clinical Surgery.

Resistance to Tyrosine Kinase Inhibitors (Resistance to Targeted Anti-Cancer Therapeutics) 1st ed

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Imaging and Intervention in Urinary Tract Infections and Urosepsis 1st ed. 2018 Edition

Aimed at practicing clinicians and radiologists, this volume provides up-to-date, detailed information on potentially severe urinary tract infections (UTIs), which frequently require intensive in-patient antibiotic therapy, percutaneous or surgical treatment. UTIs are the most prevalent infectious illness, and account for hundreds of thousands of emergency and hospital admissions yearly. Furthermore, UTIs are the most common (almost 40%) type of hospital-acquired infections, with bladder catheterisation being the key risk factor. According to the European Association of Urology guidelines, complicated urinary tract infections (C-UTIs) are those associated with structural or functional genitourinary abnormalities or with conditions that impair the host’s defence mechanisms, leading to an increased risk of acquiring infection or therapy failure.

Besides offering current perspectives from urologists, nephrologists, and specialists in infectious diseases, the book presents the techniques and highlights the role of ultrasound and contrast-enhanced ultrasound, nuclear medicine, multidetector computed tomography (CT) and magnetic resonance imaging (MRI) in providing comprehensive investigations of upper and lower tract UTIs, and of systemic infections from unknown sources. Cross-sectional imaging is currently recommended to confirm UTI, to assess severity and look for underlying treatable structural or functional abnormalities, in order to provide a consistent basis for a correct therapeutic choice.

Furthermore, dedicated chapters illustrate the current status of UTI imaging in children and the expanding role and possibilities of interventional radiology in the treatment of severe urinary tract infections.

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