Tag: Toxicology

Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary (ISSN)

Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary (ISSN) 

Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more.

Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more.

Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450.

  • Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology
  • Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans
  • Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450

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Immunotoxicology and Immunopharmacology (Target Organ Toxicology Series, 23) 3rd Edition

Immunotoxicology and Immunopharmacology (Target Organ Toxicology Series, 23) 3rd Edition

Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book’s history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals.

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Goldfrank’s Toxicologic Emergencies, Eleventh Edition 11th Edition

Goldfrank’s Toxicologic Emergencies, Eleventh Edition 11th Edition

Goldfrank’s is the premier toxicology textbook that should be in every emergency department or poison center library. Whether you are a student, resident, or faculty, there is something here for you. If you are a toxicology fellow or poison specialist studying for your boards, this is your go-to book. I highly recommend this work…

―The Journal of Emergency Medicine

The best edition yet of the landmark text in medical toxicology

A Doody’s Core Title for 2022!

Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins.

Fully referenced and supported by a cohesive organization and full-color format, Goldfrank’s begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations.

The Eleventh Edition of Goldfrank’s Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis.

New to this Edition:

• Additional cases and “Special Considerations” chapters designed to enhance clinical decision-making and patient outcomes
• New “Antidotes in Depth” provides timely, critical information on toxicologic treatment strategies
• New content on toxicogenomics explores its increasingly important role in predictive toxicology
• Chapter-ending bulleted summaries of key points
• Updated coverage of synthetics such as “K2”
• Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment tools

Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology 4th Edition

Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology 4th Edition

Haschek and Rousseaux’s Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters.

Completely revised with a number of new chapters, Volume 1, “Principles and the Practice of Toxicologic Pathology,” covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses “Toxicologic Pathology in Safety Assessment” and “Environmental Toxicologic Pathology”. These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of “Target Organ Toxicity”, emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

  • Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

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Basic and Clinical Toxicology of Organophosphorus Compounds

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This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

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Toxicology and Risk Assessment: A Comprehensive Introduction 2e 2nd Edition

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Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios

Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios.

Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals.

  • Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures
  • 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals
  • Written by a team of international specialists, and edited by two outstanding scientists in the field

Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

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