Fundamentals of Radiation Oncology: Physical, Biological, and Clinical Aspects, Third Edition continues to provide current, concise, and a readily available source of clinical information for busy practicing radiation oncologists.

The book consists of 26 chapters, divided into four parts:

Part I describes the basic science of radiation oncology, with discussions of radiation physics, radiation protection, and radiation biology, as well as molecular biology.

Part II describes techniques and modalities of radiation oncology including brachytherapy, intensity-modulated radiation therapy (IMRT), stereotactic radiotherapy (SRS), stereotactic body radiation therapy (SBRT), and proton therapy. Significant recent advances made in the areas of immunotherapy and combined modality therapy; as such, these chapters have also been added to this new edition.

Part III describes the clinical science of radiation oncology including risk factors, symptoms/signs, and investigations needed for the cancer diagnosis and up-to-date treatment recommendations in accordance with the new AJCC staging system. In addition, radiation treatment techniques, with an emphasis on IMRT, have been expanded to all the chapters. Also included in this version of the book is a chapter on benign diseases. Updated annotated bibliographies of latest landmark studies providing evidence-based rationale for the recommended treatments are presented at the end of each chapter.

Part IV describes palliative radiation treatments to improve the quality of life for cancer patients and the management of side effects from radiation treatment.

This book is a must-have for all radiation oncology residents, radiation oncologists and all professionals engaged in the care of cancer patients.

• New chapters on brachytherapy, IMRT/IGRT, SRS, SBRT, proton therapy, immunotherapy, combined modality therapy, and benign diseases
• Eighth edition of the AJCC staging system
• IMRT techniques for all common cancer sites, along with up-to-date treatment recommendations
• Relevant, landmark studies that provide evidence-based rationale for recommended treatments

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Combinational Therapy in Triple Negative Breast Cancer discusses TNBC at the molecular level from a holistic approach, focusing on combinational strategies targeting various pathways involved in this specific cancer type. Using a monotherapy for the treatment of cancer, especially high-grade tumors like TNBC, is mostly worthless due to the inherent genetic instability of tumor cells to develop intrinsic and acquired resistance. Combination therapy presents more, or at least the same, effectiveness with lower doses of every single agent and decreases the likelihood of chemoresistance, making it essential to understand for multiple therapy options.

The book is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of combinational therapies to treat triple negative breast cancer.

Presents up-to-date and cutting-edge knowledge of Triple negative breast cancer (TNBC) biology, clinical aspects and treatment options
Discusses novel targets and pathways involved in TNBC
Provides insights and approaches for future research on TNBC

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THE PERIPHERAL T-CELL LYMPHOMASProvides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments

Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat.

For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource:

• Covers the biological basis, epidemiology, classification, and treatment of PTCL
• Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL
• Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation
• Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations
• Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL

Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.

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