Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects 1st Edition

Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

• Provides the very latest overview of the pathogenesis of SLE
• Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease
• Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more
• Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage
• Discusses the latest treatment options on disease modifying or disease controlling agents
• Provides ‘one stop’ coverage of all the latest scientific and clinical developments in SLE

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Systemic Lupus Erythematosus

This book provides a comprehensive overview of the basic and clinical sciences of Systemic Lupus Erythematosus. It is suitable for basic scientists looking for detailed coverage of their areas of interest. It describes how advances in molecular biology have increased our understanding of this disease. It is a valuable clinical resource for practicing clinicians from different disciplines including rheumatologists, rheumatology fellows and residents. This book provides convenient access to information you need about cytokines, genetics, Fas pathway, toll like receptors and atherogenesis in SLE. Animal models have been reviewed as well. How to avoid delay in SLE diagnosis and management, in addition to various clinical manifestations including pregnancy and SLE have all been explained thoroughly in this book.

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Systemic Lupus Erythematosus: Methods and Protocols (Methods in Molecular Biology, 1134) 2014th Edition

Systemic Lupus Erythematosus: Methods and Protocols describe a number of genetic, biochemical and immunological techniques. These techniques provide an advancing understanding of the pathology, breakdown of the immune system and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Systemic Lupus Erythematosus: Methods and Protocols appeal to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level.

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Lupus Renal Involvement: A Case-based Atlas UK ed. Edition

Systemic lupus erythematosus (SLE or lupus) is a fairly common disease with a relatively high mortality rate that is characterized by multisystemic disorders, including the kidney. Recently, epidemiologic studies also show that the incidence of new SLE cases is increasing. Renal involvement is very common in systemic lupus erythematosus, occurring in up to 2/3 of patients and is a major cause of morbidity and mortality. Lupus nephritis affects glomeruli, tubules, interstitium peritubular capillaries, arteries, and veins with a spectrum of lesion. Although tubular, interstitial, and vascular lesions are common in lupus nephritis and may contribute significantly to overall disease severity, activity, and chronicity, they are not considered in most important classifications (OMS and ISN/RPS). These classifications are based entirely on the evaluation of glomerular alterations. Furthermore, the increasingly recognized, new pathological entity called lupus podocitopathy in the context of SLE, is not also accepted in the above classifications. Amyloidosis, non-lupus nephritides (including IgA nephropathy), therapeutic nephrotoxicity, and lupus in overlap with other connective tissue diseases are occasionally described. Therefore, this new case-based book fills a gap in the literature, and the authors call attention to some clinical entities which are less known and more difficult to recognize. The book design allows correlating morphologic aspects with clinical findings, and determines the prognosis and therapeutic response. It is a useful resource for pathologists, nephrologists, rheumatologist, physicians, and lupus and kidney students. Each case consists of typical histology images, a brief history, diagnosis, discussion, and pearls and pitfalls. The book is based on a multicenter experience, and the importance of kidney biopsy in the differential diagnosis is emphasised.

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Dubois’ Lupus Erythematosus and Related Syndromes – E-Book: Expert Consult – Online and Print 9th Edition

For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes.

• Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.
• Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients.
• Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS).
• Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment.
• Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

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Advanced Handbook of Systemic Lupus Erythematosus 1st ed. 2018 Edition

This book will provide an introduction to the epidemiology, etiology and pathogenesis of the condition while also exploring the classification, diagnosis, and current and emerging therapies for systemic lupus erythematosus. Systemic lupus erythematosus is an autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs. The underlying cause of the disease is not fully known, and SLE is much more common in women than in men. It may occur at any age but most often occurs in people between 10 and 50 years of age. This is the second Adis title from Ronald F van Vollenhoven, who previously authored Biologics for the Treatment of Rheumatoid Arthritis.

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Differential Diagnosis in Computed Tomography 2nd edition

The new Burgener: Improve your interpretation skills with this bestselling comprehensive reference to interpreting abnormal CT findings

Differential Diagnosis in Computed Tomography, 2nd edition, is an invaluable reference aid in the evaluation of CT images to help confidently gain a general diagnostic impression and a reasonable differential diagnosis. In contrast to disease-oriented radiology texts, this book is organized by CT findings, enabling the reader to quickly match the appropriate differential diagnosis to CT results.

Special features of the second edition:

• Continuation of the successful Burgener concept: Comprehensive tables describe the imaging patterns of the various diseases that may present on CT, along with other characteristically associated imaging findings and pertinent physiopathologic, pathologic, and clinical data
• Over 2,000 detailed, high-quality images demonstrating a wide range of common and uncommon CT findings
• Chapters organized according to anatomic regions, from the brain to the pelvis and the musculoskeletal system, with new chapters on meningeal and calvarian lesions and on trauma
• Updated and revised sections reflecting the latest advances in CT technology and indications, including accurate staging of intra-articular and spinal fractures and evaluation of vascular diseases
• Extensive index systematically cross-references diseases and CT findings for optimal access to information

Recognizing the central role that CT plays in the field of modern medical imaging, this book is essential for physicians who want to strengthen their diagnostic acumen and CT interpretation skills: radiologists in practice; residents preparing for board exams; and any other physician charged with understanding and interpreting CT images.

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Receptor Biology (No Longer Used) 1st Edition

This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling. The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. It goes on covering each receptor superfamily in detail including their structure and evolutionary context. The last part focusses exclusively on examples where thorough knowledge of receptors is critical: pharmaceutical research, developmental biology, neurobiology and evolutionary biology. Richly illustrated, the book is perfectly suited for all courses covering receptor based signaling, regardless whether they are part of the biology, medicine or pharmacology program.

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Receptor Binding Techniques (Methods in Molecular Biology, 897) 3rd ed. 2012 Edition

A broad definition of a receptor is a specialized protein on or in a cell that recognizes and binds a specific ligand  to undergo a conformational change, leading to a physiological response or change in cell function.  A ligand can be an endogenous neurotransmitter, hormone, paracrine/autocrine factor, or a synthetic drug that may function as an agonist or antagonist. The third edition of  Receptor Binding Techniques expands upon the methods and techniques used for studying receptors in silico, in vitro and in vivo. Comprehensive chapters describe how to use online resources for experimental research such as prediction of receptor-ligand interactions and mine the IUPHAR receptor database. Classical techniques of radioligand binding, quantitative autoradiography and their analyses are complemented by the use of  immunocytochemistry  for the cellular localization of receptor protein and hybridization to detect receptor mRNA.  Protocols using fluorescent labeled ligands are described to visualise receptors in living cells, their interaction with beta-arrestin to measure ligand-induced internalisation and  green fluorescent protein to study  trafficking. Non-radioactive, chemiluminescent cAMP and arrestin assays facilitate the identification of novel ‘biased agonists’. Detailed methods are provided for in vivo imaging of receptors using positron emission tomography (PET).

Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Receptor Binding Techniques, Third Edition, aids scientists in continuing to study receptor binding.

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