Churchill’s Pocketbook of Differential Diagnosis (Churchill’s Pocketbooks) 4th Edition

Churchill’s Pocketbook of Differential Diagnosis (Churchill’s Pocketbooks) 4th Edition

Making a correct diagnosis is one of the key aspects of every medical student’s and junior doctor’s clinical training, and problem-based learning is now widely used to focus on the causes behind the presentation of a clinical feature. The Fourth Edition of this best-selling book is packed full of information to help the reader move from a presenting problem to an accurate diagnosis.

  • This Fourth Edition covers 127 common presenting problems in both medicine and surgery in a consistent format.

  • Each topic includes a list of all potential causes of the condition, colour coded to indicate common, occasional or rare causes. Important geographical variations are also highlighted.

  • Two sections cover the differential diagnosis of biochemical and haematological disorders which provide a ready check when reviewing abnormal results

  • The text includes a targeted guide to the relevant general and specific follow-up investigations which should be carried out as appropriate.

  • At the end of each topic a box highlights important learning points, or indicates symptom and signs suggestive of significant pathology which require urgent action.
  • Eighty colour photographs of key clinical presentations have been added to assist symptom recognition.

  • Two new chapters on Hypotension and Photophobia.

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Principles and Practice of Clinical Parasitology 1st Edition

Evolution and Development: Conceptual Issues (Elements in the Philosophy of Biology)

Evolution and Development: Conceptual Issues (Elements in the Philosophy of Biology)

The intersection of development and evolution has always harbored conceptual issues, but many of these are on display in contemporary evolutionary developmental biology (evo-devo). These issues include: (1) the precise constitution of evo-devo, with its focus on both the evolution of development and the developmental basis of evolution, and how it fits within evolutionary theory; (2) the nature of evo-devo model systems that comprise the material of comparative and experimental research; (3) the puzzle of how to understand the widely used notion of ‘conserved mechanisms’; (4) the definition of evolutionary novelties and expectations for how to explain them; and (5) the demand of interdisciplinary collaboration that derives from investigating complex phenomena at key moments in the history of life, such as the fin-limb transition. This Element treats these conceptual issues with close attention to both empirical detail and scientific practice to offer new perspectives on evolution and development. This title is also available as Open Access on Cambridge Core.

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Basic Skills in Interpreting Laboratory Data 6th Edition

Basic Skills in Interpreting Laboratory Data 6th Edition

Basic Skills in Interpreting Laboratory Data continues to be the most popular teaching text on laboratory data for pharmacy students as well as the go-to reference for pharmacists in therapeutic practice. Now in its sixth edition, it has been expanded and updated to cover new drugs, research, and therapeutic approaches. The sixth edition is a comprehensive, in-depth guide to all aspects of lab work that apply to clinical practice. Written by 40 established clinicians and pharmacy faculty members and reviewed by additional experts, it is designed to make all information clear and quickly accessible. Minicases provide clinical scenarios for using tests and managing patients, and quickview charts throughout offer clear interpretations of lab results. New to this edition:* A new chapter on point-of-care testing.* New materials on male infertility workups.* Data on pharmacogenomics testing for neuropsychiatric drugs.* At least one new case and new learning points for almost all chapters.* New discussions in many chapters, including for C-reactive protein, antiglycan antibody and lactoferrin, antithroglobulin antibody, and cryoglobulin, and more.* 23 chapters are now divided into three sections: Basic Concepts and Test Interpretations, System Disorders and Diagnostic Tests, and Tests for Special Populations. Complex but critical skills are required for clinical pharmacists to effectively use lab data in screening for or diagnosing diseases and in monitoring the safety and effectiveness of treatment. As the only book of its kind specifically written for pharmacists by pharmacists, Basic Skills in Interpreting Laboratory Data makes it easier to make accurate and critical decisions based on laboratory data.

Important Correction Notice

The publishers wish to inform you of a correction in Chapter 6, page 110.

On page 110, Chapter 6, Interpretation of Serum Drug Concentrations, the equation before the heading “Valproic Acid” in the right column should appear as:

normalized PHT concentration = measured PHT concentration
+ (0.01 x VPA concentration x measured PHT concentration)

In the published book, the equation has boxes where multiplication symbols should appear.

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Biomaterials for 3D Tumor Modeling (Materials Today) 1st Edition

Biomaterials for 3D Tumor Modeling (Materials Today) 1st Edition

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer.
This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.

– Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles
– Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types
– Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

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Monte Carlo in Heavy Charged Particle Therapy: New Challenges in Ion Therapy (ISSN) 1st Edition

Monte Carlo in Heavy Charged Particle Therapy: New Challenges in Ion Therapy (ISSN) 1st Edition

This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them.

Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics.

It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical staff.

Key Features:

  • Explores the exciting and interdisciplinary topic of Monte Carlo in particle therapy and medicine
  • Addresses common challenges in the field
  • Edited by an authority on the subject, with chapter contributions from specialists

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Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models 1st Edition

Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models 1st Edition

How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes.

Key Features:

  • Full-color illustration program with diagrams to help illuminate the concepts
  • Enables the reader to apply modeling and theory to the biological processes
  • Further Reading for each chapter
  • High-quality figures available for instructors to download

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Directed Evolution: Methods and Protocols (Methods in Molecular Biology Book 2461)

Directed Evolution: Methods and Protocols (Methods in Molecular Biology Book 2461)

This volume explores the latest techniques used by researchers to study directed evolution (DE) at each stage of the Design-Build-Test-Learn cycle. Chapters in this book cover topics such as designing overlap extension PCR primers for protein mutagenesis; antha-guided automation of Darwin assembly for the construction of bespoke gene libraries; rapid cloning of random mutagenesis libraries using PTO-Quickstep; and DE of glycosyltransferases by a single-cell screening method. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Cutting-edge and comprehensive, 
Directed Evolution: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about this field and incorporating these studies into new experimental workflows.

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Practical Skills in Biomolecular Science 5th Edition

Practical Skills in Biomolecular Science 5th Edition

If you are studying the biomolecular sciences – including biochemistry, biomedical sciences, biotechnology, genetics, microbiology and molecular biology – then this book will be an indispensable companion throughout the whole of your degree programme. It provides effective explanation and support for the development of a wide range of laboratory and data analysis skills that you will use time and again during the practical aspects of your studies. This book also gives you a solid grounding in the broader transferable skills, which are increasingly necessary to achieve a high level of academic success.

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