Alzheimer’s Disease: Methods and Protocols (Methods in Molecular Biology Book 2561)

This volume explores the latest techniques used to study the human brain towards understanding Alzheimer’s Disease and related neurodegenerative disorders. Contributed to by world-renowned experts, the chapters in this book are divided into five parts. Part One discusses human post-mortem brain preparations including single-cell isolation and use of specialized imaging. Part Two talks about neural cellular models using primary and human induced pluripotent stem cells to model aspects of the human brain. Part Three details nucleic acid analyses including transcriptomic and somatic genomic changes, and Part Four discusses lipid analyses via mass spectrometry. Lastly, Part Five covers protein analyses, particularly Aβ and Tau. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Alzheimer’s Disease: Methods and Protocols is a valuable tool for all researchers who want to expand their knowledge and understanding of this disease and other related dementias.

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Chromaffin Cells: Methods and Protocols (Methods in Molecular Biology Book 2565)

This volume covers the most up-to-date methods and techniques used to further the understanding of chromaffin cell biology and pharmacology. Chapters guide readers through the basic mechanisms that regulate the stimulus-secretion coupling, chromaffin, tumor-derived cell PC-12 , morphology, biochemistry, pharmacology, electrophysiology, and electrochemistry. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Chromaffin Cells: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

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Virus as Populations: Composition, Complexity, Quasispecies, Dynamics, and Biological Implications 2nd Edition

Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.

The book’s main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.

• Features current views on key steps in the origin of life and origins of viruses
• Includes examples relating ancestral features of viruses with their current adaptive capacity
• Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read
• Considers quasispecies as a framework to understand virus adaptability and disease processes

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Fundamental Medical Mycology 1st Edition

Medical mycology deals with those infections in humans, and animals resulting from pathogenic fungi. As a separate discipline, the concepts, methods, diagnosis, and treatment of fungal diseases of humans are specific. Incorporating the very latest information concerning this area of vital interest to research and clinical microbiologists,Fundamental Medical Mycology balances clinical and laboratory knowledge to provide clinical laboratory scientists, medical students, interns, residents, and fellows with in-depth coverage of each fungal disease and its etiologic agents from both the laboratory and clinical perspective. Richly illustrated throughout, the book includes numerous case presentations.

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Bone and Joint Infections: From Microbiology to Diagnostics and Treatment 2nd Edition

BONE AND JOINT INFECTIONS

Explore this comprehensive presentation of bone and joint infections, including non-implant and implant-associated orthopedic infections

In the newly revised Second Edition of Bone and Joint Infections: From Microbiology to Diagnostics and Treatment, accomplished researcher and author Werner Zimmerli delivers a comprehensive overview of the most recent developments in the subject of bone and joint infection. Covering much of the new information appearing over the last five years, the book includes four new chapters presenting the diagnostic approach in bone and joint infections, discussing the identification of pathogens by non-culture techniques, management of multi-resistant bacteria in bone and joint infections ­by bacteriophages, and unusual microorganisms in periprosthetic joint infections.

Many of the chapters are also updated to include new information on topics like eubacterial PCR, multiplex PCR, and the shotgun metagenomics approach. These subjects are of increased applicability and interest to increase the fraction of cases with identified pathogens. The book also helps clinicians to understand MRI-based images and rapidly interpret and plan for comprehensive therapy.

Readers will also benefit from the inclusion of:

• A thorough introduction to the pharmacokinetics and pharmacodynamics of antibiotics in bone and preclinical models of infection in bone and joint surgery
• An exploration of native joint arthritis in children and adults, as well as an overview of septic arthritis of axial joints
• A practical discussion of the general aspects of periprosthetic joint infection, as well as specific aspects of periprosthetic joint infection after total hip and knee, shoulder, elbow, and ankle arthroplasty
• A concise treatment of osteomyelitis in children and adults

Perfect for infectious disease specialists, microbiologists, orthopedic and trauma surgeons, and internists, Bone and Joint Infections: From Microbiology to Diagnostics and Treatment will also earn a place in the libraries of professionals working in the implant industry and pharmaceuticals, as well as clinical pharmacologists and rheumatologists.

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Microbiology with Diseases by Taxonomy 6th Edition

For courses in introductory microbiology.

Explore the invisible world of microbiology and why it matters to human life

Known for its unique art program and conversational writing style, Robert Bauman’s Microbiology with Diseases by Taxonomy consistently emphasizes why microbiology matters, especially in health care. The taxonomic organization of the disease chapters (Chapters 19―27) presents microbial diseases by type of pathogenic microbe, helping students recognize shared characteristics among categories of microbes.

The 6th Edition presents a revitalized and strengthened pedagogical framework based on how students learn best. Checkpoints appear throughout the text and direct students to interactive versions of text features in Mastering Microbiology. The interactive features provide just-in-time remediation that helps fill skill gaps and gives students immediate feedback on their progress with the material. New interactive concept maps provide opportunities for students to construct their knowledge and can be assigned in Mastering Microbiology. To emphasize how our understanding of microbiology is constantly expanding, the new edition integrates cutting-edge microbiology research that is critical for today’s students. New Research on Microbial metabolism is introduced in Chapter 5 as well as recent findings on recombinant DNA technology and CRISPR technique are found in Chapter 8.

Also available as a Pearson eText or packaged with Mastering Microbiology

Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience available within Mastering Microbiology. It lets students highlight, take notes, and review key vocabulary all in one place – even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class.

MasteringTM is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools developed to engage students and emulate the office-hour experience, Mastering personalizes learning and improves results for each student. Mastering Microbiology provides tutorials, animations and career relevant applications that enable students to see the invisible world of microbiology, to master key microbiology concepts, and to apply those concepts to human life.

Note: You are purchasing a standalone product; Mastering Microbiology does not come packaged with this content. Students, if interested in purchasing this title with Mastering Microbiology, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information.

If your instructor has assigned Pearson eText as your main course material, search for:

• 0135799996 / 9780135799994 Pearson eText Microbiology with Diseases by Taxonomy 6/e — Access Card
OR
• 0135800013 / 9780135800010 Pearson eText TMicrobiology with Diseases by Taxonomy, 6/e– Instant Access

If you would like to purchase both the physical text and Mastering Microbiology search for:

013515992X / 9780135159927 Microbiology with Diseases by Taxonomy Plus Mastering Microbiology with Pearson eText — Access Card Package

Package consists of:

0134832302 / 9780134832302 Microbiology with Diseases by Taxonomy
0134999517 / 9780134999517 Mastering Microbiology with Pearson eText — ValuePack Access Card — for Microbiology with Diseases by Taxonomy

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