Category: Pharmacology

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There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species.

In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on ‘Metallotherapeutics’ throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered:

• non-invasive radiopharmaceuticals
• Magnetic Resonance Imaging (MRI)
• mineral supplements

From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.

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This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing.

As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout.

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From its origins as a niche technique more than 15 years ago, fragment–based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment–based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment–based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment–based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on–going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein–protein interaction and epigenetic targets.

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Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).

The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

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PHARMACY TECHNICIAN CERTIFICATION EXAM REVIEW, 3E is a comprehensive, all inclusive study tool to help prepare your students to become certified pharmacy technicians on a national level. This book mirrors content covered on the Pharmacy Technician Certification Exam (PTCE) and provides both exam content review and practice opportunities in a variety of formats. Ideal for review courses and for individual study, this book is a must-have tool for anyone preparing to take the PTCB and ExCPT exams. Sections are structured to help your students focus on critical topic areas outlined by the Pharmacy Technician Certification Board; including 14 chapters specifically on mathematics with examples and end-of-chapter review questions. This new edition also includes greatly expanded chapters on pharmacology, updated end-of-chapter practice questions, two cumulative tests at the end of the book, and solutions to all chapter review questions and practice exams. For even more practice, the back-of-book CD offers 600 additional review questions to create timed exams that simulate the actual PTCE!

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The third edition of Pharmaceutical Process Scale-Up deals with the theory and practice of scale-up in the pharmaceutical industry. This thoroughly revised edition reflects the rapid changes in the field and includes:

• New material on tableting scale-up and compaction.
• Regulatory appendices that cover FDA and EU Guidelines.
• New chapters on risk evaluation and validation as related to scale-up.
• Practical advice on scale-up solutions from world renowned experts in the field.

Pharmaceutical Process Scale-Up, Third Edition will provide an excellent insight in to the practical aspects of the process scale-up and will be an invaluable source of information on batch enlargement techniques for formulators, process engineers, validation specialists and quality assurance personnel, as well as production managers. It will also provide interesting reading material for anyone involved in Process Analytical Technology (PAT), technology transfer and product globalization.

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DRUG USE AND ABUSE takes an interdisciplinary approach in its coverage of current drug issues. It weaves psychological, historical, cultural, social, biological, and medical perspectives — emphasizing the idea that a drug’s effects depend not only on its properties, but also on the biological and psychological characteristics of its user. This theme is highlighted throughout, and is prominent in discussions of the individual classes of drugs, as well as in the chapters on pharmacology and psychopharmacology.

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With this fully revised fourth edition, Dr Stahl returns to the essential roots of what it means to become a neurobiologically empowered psychopharmacologist, expertly guided in the selection and combination of treatments for individual patients in practice. Embracing the unifying themes of ‘symptom endophenotypes’, dimensions of psychopathology that cut across syndromes, and ‘symptoms and circuits’, every aspect of the text has been updated to the frontiers of current knowledge, with the clarity of explanation and illustration that only Dr Stahl can bring. Integrating much of the basic neuroscience into the clinical chapters, and with major additions in the areas of psychosis, antipsychotics, antidepressants, impulsivity, compulsivity and addiction, this is the single most readily readable source of information on disease and drug mechanisms. This remains the essential text for all students and professionals in mental health seeking to understand and utilize current therapeutics, and to anticipate the future for novel medications.

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As the most common health-care intervention, prescription drug use shares the most important characteristics of the health-care system in the United States. When everything works well, it makes possible breathtakingly successful applications of science to the prevention and cure of human suffering. But everything doesn’t always work well.

Pharmaceutical Public Policy provides the understanding and framework required for effective organization, financing, and delivery of pharmaceutical products and services. It supplies an overview of the policy process as well as the roles of legislation and regulation in pharmaceutical policy.

The book identifies the goals, objectives, and key policy issues of concern to stakeholders involved in the development of products, use of pharmaceuticals in healthcare, and administration of insurance programs by both the private and government sectors. Policy issues examined include the appropriateness of prescribing and patient adherence.

Addressing questions of access, quality, and cost, the book considers the operation of the Affordable Care Act and Medicare Part D. It details the responsibilities of Federal providers of pharmaceutical care and private and public payers such as managed care organizations, pharmacy benefit managers, Medicare, and Medicaid.

The book covers the policies and practices involved in promoting pharmaceutical products. It also considers pharmacoeconomics as a response to market failure. Finally, the book describes the market, the role of the manufacturer, drug shortages, and the responsibilities of the FDA.

The book includes a Foreword by Jerry Avorn, MD, Professor of Medicine, Harvard Medical School; and Chief, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Woman’s Hospital

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