Category: Pharmacology

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Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).

The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

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The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates.

The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book.

Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum.

Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.

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While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

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The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This book explores the evolving definition of innovation in therapeutic product development and begins to examine its effects on the life sciences R&D industry.

Historically, scientific innovation alone was sufficient to maintain ROI and deliver on unmet medical needs. However, with many forces now conspiring to increase pressures on the commoditization of drug development, industry support for truly novel, often high-risk development has eroded. This calls for a drastic redefinition of what “innovation” is. While innovation in the pharmaceutical R&D industry has historically been applied to major advances in therapy and unmet medical needs, we now need to see innovation increasingly defined in terms of financial, marketing (e.g. branded generics and emerging markets), pharmacoeconomic, and operational innovation.

In this book, contributors drawn from the executive ranks of clinical development practitioners and stakeholders―from biopharmaceutical companies, clinical research organizations, academia, the financial community, and the patient perspective―have all come together to provide their expertise and visions. Their goal is to start a dialogue about ways to radically improve therapeutics development and get more and better medicines to the patients who need them, as fast as possible, in the most cost-efficient manner.

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This volume of Modern Aspects of Electrochemistry reviews the latest developments in electrochemical science and technology related to biomedical and pharmaceutical applications.
In particular, this book discusses electrochemical applications to medical devices, implants, antimicrobially active materials, and drug delivery systems.

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This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

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The most effective and comprehensive pharmacy review for the NAPLEX®

The ultimate pharmacy review covering every topic tested on the exam

Companion CD-ROM prepares you for the computerized format of the NAPLEX®

1500+ NAPLEX-style Q&As deliver unmatched preparation for the exam

• Build confidence and test-taking skills with more than 1500 NAPLEX®-style questions and tried-and-proven tips for boosting exam performance
• Learn from detailed explanations why answers are correct or incorrect
• Familiarize yourself with computerized testing with the companion CD-ROM
• Improve in every essential competency: pharmacology, pharmaceutical calculations, pharmacy, pharmaceutical compounding, biopharmaceutics and pharmacokinetics, health care equipment and supplies, and pharmaceutical care
• Recognize all frequently dispensed drugs, including the 200 generic drugs most likely to be dispensed by pharmacists

EVERYTHING YOU NEED TO EXCEL ON THE NAPLEX®

• Questions that cover every topic found on the exam
• An entire chapter devoted to patient profiles, with each profile accompanied by a series of questions
• Companion CD-ROM with 360 Q&As
• An informative description of the computer-based examination
• Two valuable appendices: frequently dispensed drugs and trade names versus generic names

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MORE THAN 1000 Q&As PREPARE YOU FOR MEDICAL PHARMACOLOGY COURSE EXAMS AND BOARD EXAMINATIONS

From the authors of pharmacology’s #1 textbook, Katzung & Trevor’s Basic & Clinical Pharmacology, Twelfth Edition, this review delivers a clear, concise review of fundamental concepts backed by more than 1,000 review questions and answers. The chapter-based approach facilitates use with course notes or larger texts.

Outstanding learning aids include:

• Short discussion of the major concepts that underlie basic principles or specific drug groups
• Explanatory figures and tables
• Review questions followed by answers and explanations
• Drug trees in drug-oriented chapters that visually organize drug groups
• A list of high-yield terms and definitions you need to know
• Skill Keeper Questions that prompt you to review previous material to understand links between related topics
• A checklist of tasks you should be able to perform upon completion of a chapter
• Summary tables that list the important drugs and include key information about their mechanisms of action, effects, clinical uses, pharmacokinetics, drug interactions, and toxicities
• Two comprehensive 100-question examinations followed by the correct answers and rationales
• Valuable test-taking strategies for improving your test performance

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