Category: Pharmacology

GPCRs as Therapeutic Targets

GPCRs as Therapeutic Targets 

A thorough discussion of the structure, pharmacology, function, and role of G protein-coupled receptors

In GPCRs as Therapeutic Agents, distinguished researcher Dr. Annette Gilchrist delivers an authoritative and in-depth compendium of a vibrant and active area of academic and industrial drug discovery. The book serves as an important reference for new and experienced researchers studying G protein-coupled receptors and discusses the molecular pharmacology of this important target class. It also includes up-to-date material on GPCR structures and structure-based drug design.

The book explores the role of GPCRs in the treatment of disease and novel approaches to their study. In addition to providing information on the structure, pharmacology, and function of GPCRs, it discusses their role in disease states, and advances new methods for measuring GPCR activity in an accessible and engaging way. The book includes:

A thorough introduction to the molecular pharmacology of G protein-coupled receptors, including up-to-date material on GPCR structures and structure-based drug design
In-depth discussions of the evolving pharmacology for GPCRs, intracellular trafficking, and subcellular GPCR signaling
Comprehensive explorations of allosteric modulation, receptor dimerization, deorphanization, and ubiquitination
Fulsome treatments of the role played by GPCRs in the treatments of cancer, substance use disorders, cerebrovascular diseases, and metabolic diseases
Perfect for researchers in biochemistry, cell biology, and pharmacology, GPCRs as Therapeutic Agents will also earn a place in the libraries of professionals working in medicinal chemistry, structural biology, and clinical pharmacology.

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Hale’s Medications & Mothers’ Milk 2023: A Manual of Lactational Pharmacology 20th Edition

Hale’s Medications & Mothers’ Milk 2023: A Manual of Lactational Pharmacology 20th Edition

The worldwide gold standard for lactation support professionals

Developed by world leaders in lactational pharmacology, this essential reference contains the most current, complete, and evidence-based information available on the transmission of maternal drugs into human milk. It thoroughly addresses one of the most commonly asked questions by breastfeeding mothers―which drugs are safe, and which are hazardous for the infant? The new twentieth edition adds 72 new drugs, updates 356 medications with new data, and adds new information to 927 drugs.

The resource relies upon the most current evidence-based studies to evaluate the relative risk of commonly used drugs including Dr. Hale’s highly renowned Lactation Risk Categories (LRC). Considered indispensable by hundreds of clinicians worldwide, the book lists safe alternatives for drugs one is currently taking or might need to take in the future. For ease of access to information, it includes key points and savvy tips in information boxes, common abbreviations, illustrative diagrams, concise information on evaluating the infant, and more.

New to the 2023 Edition:

  • 72 new drugs
  • 356 medications updated with new data
  • 3 drugs with FDA updates
  • 927 medications updated with new information
  • 74 existing drugs with updated LRC
  • NEW TABLES on monoclonal antibodies and migraines
  • New information on Cannabis.

Key Features:

  • Delivers current, evidence-based information on over 1300 drugs, diseases, vaccines, syndromes
  • Incorporates recent updates to Dr. Hale’s world-renowned LRC
  • Includes key points and savvy tips about breastfeeding and medications for quick reference
  • Lists common abbreviations and drugs in easily-accessible alphabetical order
  • Discusses adult concerns, adult dose, pediatric concerns, infant monitoring, and alternatives
  • Includes succinct information on evaluation of the infant

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Symptoms in the Pharmacy: A Guide to the Management of Common Illnesses 9th Edition

Symptoms in the Pharmacy: A Guide to the Management of Common Illnesses 9th Edition

A Thorough Guidebook for Assessing and Managing Common Symptoms and Illnesses Seen in the Pharmacy

Pharmacies, and pharmacists, are often the first source for information and advice used by a patient when health problems arise. This book supports pharmacists to recognize symptoms, advise with confidence, and recommend appropriate treatment or referral, while also providing a comprehensive digest of common conditions ideal for both practical use and reference.

Informed by the experiences and expertise of seasoned pharmacists and GPs, each chapter in the book provides pharmacists and their staff working in the community with a decision-making framework along with suggestions on “when to refer” contained within summary boxes. A unique feature of the book is that case studies are provided throughout, in which pharmacists, doctors, nurses and patients themselves describe assessment and treatment of a wide range of common problems.

This 9th edition of the book also includes:

  • Consideration of conducting pharmacy consultations remotely as well as in person in the pharmacy
  • New content on COVID-19 and Long-COVID in pharmacy practice
  • Information about medicines recently reclassified for OTC supply
  • Expanded content on women’s health including information on desogestrel, menopause and incontinence
  • Broadening of the insomnia chapter to include consideration of mental health problems
  • Increased content on non-drug treatment options and their supporting evidence
  • A summary of evidence sources at the end of each chapter
  • Decision-making support for unique cases which involve ethical dilemmas

Practicing and Foundation trainee pharmacists, as well as undergraduate pharmacy students and other healthcare professionals, will find Symptoms in the Pharmacy: A Guide to the Management of Common Illnesses invaluable when dealing with both common and obscure symptoms and illnesses.

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Community Pharmacy Practice Guidebook 1st Edition

Community Pharmacy Practice Guidebook 1st Edition

Get up to speed on everything there is to know about community pharmacy!

This unmatched resource provides the tools you need to operate, manage, and advance community pharmacy. The authors have gathered information from practicing community pharmacists to deliver the most salient information you need to know.

Community Pharmacy Practice Guidebook covers everything from operations and financial aspects to hiring/managing staff and important quality metrics within the community pharmacy practice setting. Delivering real-world content and practical applications for building the specific skills you need to succeed; it helps you create innovative solutions to optimize business and patient-related outcomes through clinical and value-added services specific to the community.

Features

  • Practice questions at the beginning and end of each chapter to test your knowledge.
  • Each chapter includes practical application cases to build problem-solving skills related to community pharmacy.
  • Real-life anecdotes, not just fictional situations, that provide a clear picture of how community pharmacy actually works.
  • Coverage of community pharmacy models, legal considerations, pharmacy ownership and entrepreneurship, workflow optimization, human resources management, inventory, the role of technology, payment models and methods, clinical and value-added services, risk management, quality metrics, and more.

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Kucers’ The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition – Three Volume Set 7th Edition

Kucers’ The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition – Three Volume Set 7th Edition

Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections – antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs – and is highly structured for ease of reference.

Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses – a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

10 B/W Illustrations

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Drugs for the Heart: Expert Consult – Online and Print, 8e 8th Edition

Drugs for the Heart: Expert Consult – Online and Print, 8e 8th Edition

Drugs for the Heart presents highly portable, up-to-date information on every drug class used to treat cardiovascular disease. Drs. Lionel H. Opie and Bernard J. Gersh put the latest dosages, interactions, indications and contraindications, side effects, and more at your fingertips, equipping you to make effective clinical decisions on behalf of your patients

  • Quickly check when to use each drug for any condition with the popular “Which Drug for Which Disease” chapter.
  • Get expert advice from the practice-proven experience of two well-known editors who represent the best possible combination of clinical and research expertise in cardiovascular therapeutics.
  • Expedite your reference with summaries of each drug class at the end of chapters.
  • Carry it with you anywhere thanks to a highly compact, pocket-sized format.
  • Navigate the latest pharmacologic advances through coverage of the newest drugs and drug classes, as well as all the latest clinical trial results and evidence used to treat heart disease.
  • Effectively manage comorbid diseases.
  • Apply international insights into cardiac drugs, thanks to new global contributors.
  • Visualize key pharmacologic and physiologic actions thanks to dynamic new full-color drawings.
  • Access the complete contents online at Expert Consult, with regular online updates posted by leading cardiologist, Dr. Opie.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

100 Cases in Clinical Medicine 3rd Edition

100 Cases in Clinical Medicine 3rd Edition

Making speedy and appropriate clinical decisions and then choosing the best course of action is an essential skill for doctors. Exploring initial medical assessment, 100 Cases in Clinical Medicine presents 100 scenarios commonly seen by medical students and junior doctors in the emergency or outpatient department, on the ward, or in the community setting.

Each case begins with a succinct summary of the patient’s history, examination, and initial investigation. The text includes photographs where relevant and questions on the diagnosis and management of each case. The answers provide a detailed discussion on each topic, with further illustration where appropriate.

Most of the cases included are common problems but the book also includes more unusual cases to illustrate specific points and to emphasize that rare things do present. The first 20 cases are arranged by systems; the next 80 are in random order because symptoms such as breathlessness and pain may relate to many different clinical problems in various systems.

These true-to-life cases will teach students and junior doctors to recognize important clinical symptoms and signs and to develop the diagnostic and management skills needed for the cases they will encounter on the job.

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Randomised Clinical Trials: Design, Practice and Reporting 2nd Edition

Randomised Clinical Trials: Design, Practice and Reporting 2nd Edition

Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and case studies from industry, academia, and the research literature help readers understand each stage of the clinical trial process.

This second edition contains extensively revised material throughout, including new chapters covering designs for repeated measures, non-inferiority, cluster and stepped wedge trials. Other new chapters describe data and safety monitoring, biomarker studies, and feasibility studies. Updated and expanded sections discuss situations where multiple organs, different body locations or competing risks are involved, subgroup analysis, and multiple outcomes. Written by an author team with extensive experience in conducting clinical trials, this book:

  • Provides comprehensive coverage of randomised clinical trials, ranging from basic to advanced
  • Features several new chapters, updated case studies and examples, and references to changes in regulations
  • Explains basic randomised trials, including the parallel two-group controlled trial with a single outcome measure
  • Covers paired trial designs and trials with more than two interventions
  • Includes a chapter on miscellaneous topics such as adaptive designs, large simple trials, Bayesian methods for very small trials, alpha-spending functions and the predictive probability test

Randomised Clinical Trials is essential reading for clinicians, nurses, data managers, and medical statisticians involved in clinical trials, and for health practitioners responsible for direct patient care in a clinical trial setting.

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Clinical Pharmacology 12th Edition

Clinical Pharmacology 12th Edition

‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’

The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy.

Coverage of all major therapeutic topics by body system.
Introductory sections give brief chapter synopses.
Case studies where relevant.
Covers the needs of the developing world with a focus on practical prescribing and health technology assessment.
Definition, tips, brief explanation boxes throughout.
Interesting histories, etymologies and provenances of terms throughout.
Entertaining footnotes throughout.
Fully updated throughout.
New co-editor: Fraz Mir, Addenbrooke’s Hospital and Department of Medicine, University of Cambridge.
Now with free e-book on StudentConsult.

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