Targets and Emerging Therapies for Schizophrenia 1st Edition

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Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases.

Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined.

With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia:

  • Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment
  • Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery
  • Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides

With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.

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Occupational Therapy in Orthopaedics and Trauma 1st Edition

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This book fills a gap in providing specialist information on orthopaedics and trauma occupational therapy. Its contributors bring together information on the aetiology, surgical input and the occupational therapy intervention appropriate to this client group. It is divided into two main sections, the first being orthopaedics and the second orthopaedic trauma. The first part is further subdivided to cover lower limb surgery, upper limb surgery, spinal conditions, and paediatric orthopaedic conditions. In Part two, principles of fracture management are covered, followed by pelvic and acetabular reconstruction, hand injuries and traumatic amputation.

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Infection Prevention and Control: Theory and Practice for Healthcare Professionals 1st Edition

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This book provides the reader with all of the background information necessary to enhance their understanding of the rationale behind the basic principles of infection control and how to apply them in every day situations; how specific bacteria interact with the host and cause infection; the background to each of the bacteria/infections described within the text, and, evidence based recommendations on the infection control management of these.

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Clinical Problems in General Medicine and Surgery, 2e 2nd Edition

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Clinical Problems provides a comprehensive selection of important medical and surgical scenarios. The reader is taken through 62 case histories step by step and is asked to interpret a broad range of medical data. Most of the clinical problems are accompanied by illustrations, which include cardiographs, radiographs, clinical and pathological photographs. In addition to detailed questions and answers, a commentary is provided that highlights the important issues of each case, as well as a guide to further topics of study.
The aim of any undergraduate curriculum is to produce graduates who have the knowledge and skills required to enable them to become competent members of the medical fraternity. Understandably, upon qualification these attributes will be raw and untried, but we expect them to be able to show that they possess what it is required of doctors in their first few years after graduation. What is ‘required’ in a clinical situation is often not obvious to the student and hence the reason for this book.
The book represents a departure from the traditional formula of systems and diseases, and an exhaustive review of each subject. Rather the authors have selected what they believe to be a number of important and, for the most part, relatively common medical and surgical scenarios and approached each from the perspective of the practicing clinician presented with a clinical problem. Whilst the book has been written primarily for undergraduates it describes clinical problems as they will be managed by recently qualified doctors.
It is not the purpose of this book to challenge or compete with standard reference material, rather it represents an important adjunct to the learning process of clinical reasoning, rather than provide the knowledge that must accompany it, although an considerable amount of factual material is to be found within its pages. Problem solving is a vital component of medical education, and while it can be taught well at the bedside and in small group tutorials, there are few books that help with this style of learning.

  • Addresses important medical and surgical topics from a problem-oriented approach.
  • Presents relevant clinical illustrations for each case, such as ECGs, radiographs, and clinical and pathologi-cal photographs.
  • Emphasizes empathy with the patient’s situation as well as effective patient counseling.
  • Provides commentaries from experienced clinicians, highlighting the most important issues of each case and offering suggestions on possible further areas of study.
  • Identifies situations where emergency management must take precedence over pathophysiological diagnosis.
  • Features extensive updates to reflect the increasing role of minimally invasive diagnostics.
  • Offers a new, full-color page design, with all-new photographs throughout.
  • Provides a stronger emphasis on the worldwide web as a source of further information.

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Substance Abuse Treatment for Youth and Adults: Clinician’s Guide to Evidence-Based Practice 1st Edition

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Part of the Clinician’s Guide to Evidence-Based Practice Series, Substance Abuse Treatment for Youth and Adultsprovides busy mental health practitioners with detailed, step-by-step guidance for implementing clinical interventions that are supported by the latest scientific evidence.

Edited by renowned educators David W. Springer and Allen Rubin, this thorough yet practical reference draws on a roster of experts and researchers in the field who have assembled state-of-the-art knowledge into this well-rounded guide. Each chapter serves as a practitioner-focused how-to guide and covers interventions that have the best empirical support for treating substance abuse problems, including:

  • Family behavior therapy for substance abuse and associated problems
  • Motivational interviewing
  • Problem solving and social skills training
  • Adolescent community reinforcement approach (A-CRA)
  • Cognitive behavioral coping skills therapy for adults
  • Seeking Safety treatment for clients with PTSD and substance abuse

Easy-to-use and accessible in tone, Substance Abuse Treatment for Youth and Adults is an indispensable resource for practitioners who would like to implement evidence-based, compassionate, effective interventions in their care of substance-abusing clients.

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Emerging Infectious Diseases: A Guide to Diseases, Causative Agents, and Surveillance (Public Health/Epidemiology and Biostatistics

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This important resource offers a comprehensive introduction to emerging and reemerging infectious disease, including the underlying mechanisms of microbial emergence, the technology used to detect them and the strategies available to contain them. The author describes the diseases and their causative agents that are major factors in the health of populations the world over. One of the main features of the book is its broad coverage of 25 different emerging infectious diseases, most of which are directly important to those practicing health in the U.S. The book is designed for students in epidemiology, global health, and biology.

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Medical Imaging: Essentials for Physicians

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This book is a concise, one–stop resource on medical imaging written for medical professionals, addressing a field of critical importance to them, in the language that they speak. Coauthored by a medical physicist and a clinical imaging physician, the book provides a solid working knowledge of the science and technology of image formation, including coverage of imaging modalities and how they operate, how to use the resulting diagnostic information, the proper applications of imaging, and many clinical case examples.

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Schema Therapy for Borderline

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The book was first published in Dutch by Uitgeverij Nieuwezijds – this book is an English language translation, translated from the original Dutch Language version by Jolijn Drost. The book offers a conceptual model of BPD, a treatment model and an array of methods and techniques for treating BPD clients. It covers treatment planning, the therapeutic relationships, cognitive and behavioural techniques, specific strategies, behavioural pattern breaking and the termination of therapy. The appendices contain handouts for patients including a biographical diary, forms for homework assignments and problem solving and a positive self statement log.

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Radiation Biology of Medical Imaging

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This book provides a thorough yet concise introduction to quantitative radiobiology and radiation physics, particularly the practical and medical application. Beginning with a discussion of the basic science of radiobiology, the book explains the fast processes that initiate damage in irradiated tissue and the kinetic patterns in which such damage is expressed at the cellular level. The final section is presented in a highly practical handbook style and offers application–based discussions in radiation oncology, fractionated radiotherapy, and protracted radiation among others. The text is also supplemented by a Web site.

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Topical and Transdermal Drug Delivery: Principles and Practice Hardcover – 27 Jan 2012

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By understanding the mechanisms by which compounds cross the skin, it becomes possible to devise means for improving drug delivery. Providing an overview of the current science in drug and cosmetic application to and through the skin, Topical and Transdermal Drug Delivery includes treatment of skin conditions, skin permeation, and enhancement and measurement of skin permeation. The book provides pharmaceutical scientists, skin product development experts, and those in the cosmetic and personal care industry with practical knowledge and insight into future product development.

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