Ankylosing Spondylitis: The Facts (The Facts Series) Reprint Edition

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Ankylosing spondilitis is a chronic form of arthritis known to affect around 1 in 200 people (over 1 million sufferers in the USA alone). No cure has yet been found for the disease, however, early diagnosis and proper medical management can be important in reducing the risk of disability and deformity. Ankylosing spondilitis: the facts is the first mass market book to be published on this important disease. It provides clear and accessible information on treatment, diagnosis, genetic counselling, and daily life with this illness. Professor Khan is one of the leading experts in the world on AS, while also suffering from it. This combination of scientific knowledge and personal experience of a debilitating disorder results in a unique book which will prove invaluable for sufferers wishing to know more about their condition, and those that share their lives.

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Human Gross Anatomy: An Outline Text 1st Edition

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This text presents gross anatomy in an expanded outline format. Its conciseness and logical organization permit easy previewing of the subject matter before a lecture or laboratory as well as efficient learning and reviewing of the material before an examination. Notwithstanding its succinct style, the text’s coverage of gross anatomy is comprehensive and is written at a level of detail appropriate for the medical student.
The book begins with an introduction, setting forth basic principles and terminology that will serve the student throughout the remainder of the text. Overviews of the nervous, muscular, skeletal, and vascular systems are also included in the introduction. The main part of the text is organized in the following sequence: The Back; The Thorax; The Abdomen; The Perineum and Pelvis; The Head and Neck; The Upper Limb; and The Lower Limb. Clinical notes that highlight anatomy relevant to current medical practice appear throughout these chapters. Since each regional anatomy chapter is complete in itself, the order in which they are studied is optional.

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AIDS-Related Cancers and Their Treatment (Basic and Clinical Oncology) 1st Edition

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This book summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS.
Presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system.
Illustrates points with clear and easily read figures, tables, and flow charts!
Written to survey the magnitude of the impact HIV and AIDS have had on public health and oncology, AIDS-Related Cancers and Their Treatment

  • identifies types of cancer and gives evidence for their associations with immunosuppression
  • compares and contrasts AIDS-related cancer with non-HIV malignancies
  • investigates the pathogenesis of malignancy in HIV/AIDS patients
  • provides guidelines for recognizing possible symptoms and making accurate diagnoses
  • supplies algorithms for evaluating and staging patients at presentation
  • outlines potential problems and obstacles in caring for AIDS-related cancer patients
  • suggests optimal therapeutic approaches for the care of patients with AIDS and cancer
  • discusses prognostic factors in response to therapy and survival statistics
  • describes preliminary experience with emerging therapies and projects new approaches
  • advises how to enroll patients to participate in clinical trials of new therapies
  • considers the psychological impact on patients and their need for counseling and support
  • reviews access-to-care issues in AIDS and the community burden of this epidemic
  • provides information sources for both AIDS patients and their physicians
  • and more
    With contributions from nearly 25 clinicians and citing more than 1200 references to support and elaborate on text material, AIDS-Related Cancers and Their Treatment is a crucial reference for oncologists, immunologists, infectious disease specialists, hematologists, internists, microbiologists, virologists, epidemiologists, molecular and cell biologists, pathologists, and medical students in these disciplines.

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The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology 1st Edition

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Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease.

The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states.

Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section.  The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position.

  • Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota
  • Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition
  • Explores the relationship humans have with their microbiota, and its significance in human health and disease
  • Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease

Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

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Pathogenesis of Neurodegenerative Disorders (Contemporary Neuroscience) Softcover reprint of hardcover 1st ed. 2001 Edition

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As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor­ ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro­ mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa­ tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.

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Advanced Digestive Endoscopy: ERCP 1st Edition

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Advanced Digestive Endoscopy: ERCP addresses some of the most complex diagnostic and therapeutic procedures for endoscopists. It provides the latest thinking and clear instruction on the techniques, which have been integrated with overall patient care.

Written by the leading international names in endoscopy, the text has been expertly edited by Peter Cotton into a succinct, instructive format. Presented in short paragraphs structured with headings, subheadings and bullet points and richly illustrated throughout with full-color photographs.

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BizTalk 2013 EDI for Health Care: HIPAA-Compliant 834 (Enrollment) and 837 (Claims) Solutions 2nd ed. Edition

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BizTalk 2013 EDI for Healthcare – EDI 834Enrollment Solutions eliminates the complexity anddemonstrates how to build both inbound and outbound EDI 834 processes inBizTalk server that follow the required patterns for integrations with theseexchanges. Archiving, mapping,reconstituting EDI 837 data, exception handling and advanced logging andreporting (without the need for BAM!) are all covered in enough detail to allowyou to implement your own fully functional solution.

The Affordable CareAct and the requirements to integrate with state Exchanges have securedBizTalk’s role with integrations within the healthcare industry. EDI 834 documents are the heart to allintegrations, dealing with enrollment and the maintenance of enrollments. In order to successfully integrate with theexchanges, companies are required to implement a number of architectural componentsthat can be daunting and complex to work through. High-quality resources for IT professional to handle these challenges are sorely needed, and this resource has been designed to provide concise solutions.

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Assessing and Treating Low Incidence/High Severity Psychological Disorders of Childhood 2011th Edition

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During the past several decades, interest in children’s psychological disorders has grown steadily within the research community, resulting in a burgeoning knowledge base. The majority of the attention and funding, not surprisingly, has focused on the more prevalent and well-known conditions. Although this raises the odds that young people with more well-known disorders such as ADHD, autism, and learning disorders will receive much-needed professional assessment and intervention, children with less frequently encountered disorders may experience a higher risk of misdiagnosis and inappropriate treatment.

Useful data has been scattered throughout the literature for severe-but-less-frequent childhood psychological disorders, including: fire setting; gender identity disorder; impulse control disorders (i.e., kleptomania, trichotillomania, intermittent explosive disorder); selective mutism; Munchausen by proxy; childhood schizophrenia; gang involvement; sexual offending; self-injurious behavior; and feral children. This concise volume offers up-to-date information on these conditions, which, though relatively rare, may have profound effect not only on the children themselves but also their families, friends, and the community at large. Coverag

e of each disorder is presented in an accessible format covering:

  • Overview and history.
  • Description and diagnostic classification, with proposed changes to the DSM-V.
  • Etiology and theory.
  • Assessment tools and interview protocols.
  • Commonly used psychological and pharmacological treatment options.
  • Current research issues and directions for future investigation.

Assessing and Treating Low Incidence/High Severity Psychological Disorders of Childhood is a must-have reference for researchers, clinicians, practitioners, and graduate students in clinical child and school psychology, pediatrics, psychiatry, social work, school counseling, education, and public policy.

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The ASCRS Manual of Colon and Rectal Surgery 2nd ed. 2014 Edition

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The ASCRS Manual of Colon and Rectal Surgery, Second Edition is designed to provide a rapid access pocket reference for residents, fellows, private clinicians, and allied health professionals caring for patients with colorectal surgical diseases. The Manual, abstracted from the ASCRS Textbook of Colon and Rectal Surgery, Second Edition, is intended to impart succinct, clinically relevant information for daily patient care. The chapters take an evidence-based approach and many provide ASCRS practice parameters. The contents are presented consistently, with concise overviews of the most clinically relevant topics. The disease chapters discuss etiology, anatomic considerations, patient evaluation, lab results, imaging, diagnosis and treatment. The surgical chapters address these same issues, in addition to discussion of minimally invasive versus open techniques, possible complications, and perioperative care. The Manual also includes anatomical and technique drawings, operative photos and algorithms.

Concise yet comprehensive, The ASCRS Manual of Colon and Rectal Surgery, Second Edition is very useful for physicians and researchers dealing with diseases of the colon and rectum.

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Re-inventing Drug Development 1st Edition

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The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This book explores the evolving definition of innovation in therapeutic product development and begins to examine its effects on the life sciences R&D industry.

Historically, scientific innovation alone was sufficient to maintain ROI and deliver on unmet medical needs. However, with many forces now conspiring to increase pressures on the commoditization of drug development, industry support for truly novel, often high-risk development has eroded. This calls for a drastic redefinition of what “innovation” is. While innovation in the pharmaceutical R&D industry has historically been applied to major advances in therapy and unmet medical needs, we now need to see innovation increasingly defined in terms of financial, marketing (e.g. branded generics and emerging markets), pharmacoeconomic, and operational innovation.

In this book, contributors drawn from the executive ranks of clinical development practitioners and stakeholders―from biopharmaceutical companies, clinical research organizations, academia, the financial community, and the patient perspective―have all come together to provide their expertise and visions. Their goal is to start a dialogue about ways to radically improve therapeutics development and get more and better medicines to the patients who need them, as fast as possible, in the most cost-efficient manner.

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