Receptor Biology (No Longer Used) 1st Edition

Receptor Biology (No Longer Used) 1st Edition

This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling. The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. It goes on covering each receptor superfamily in detail including their structure and evolutionary context. The last part focusses exclusively on examples where thorough knowledge of receptors is critical: pharmaceutical research, developmental biology, neurobiology and evolutionary biology. Richly illustrated, the book is perfectly suited for all courses covering receptor based signaling, regardless whether they are part of the biology, medicine or pharmacology program.

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Receptor Binding Techniques (Methods in Molecular Biology, 897) 3rd ed. 2012 Edition

Receptor Binding Techniques (Methods in Molecular Biology, 897) 3rd ed. 2012 Edition

A broad definition of a receptor is a specialized protein on or in a cell that recognizes and binds a specific ligand  to undergo a conformational change, leading to a physiological response or change in cell function.  A ligand can be an endogenous neurotransmitter, hormone, paracrine/autocrine factor, or a synthetic drug that may function as an agonist or antagonist. The third edition of  Receptor Binding Techniques expands upon the methods and techniques used for studying receptors in silico, in vitro and in vivo. Comprehensive chapters describe how to use online resources for experimental research such as prediction of receptor-ligand interactions and mine the IUPHAR receptor database. Classical techniques of radioligand binding, quantitative autoradiography and their analyses are complemented by the use of  immunocytochemistry  for the cellular localization of receptor protein and hybridization to detect receptor mRNA.  Protocols using fluorescent labeled ligands are described to visualise receptors in living cells, their interaction with beta-arrestin to measure ligand-induced internalisation and  green fluorescent protein to study  trafficking. Non-radioactive, chemiluminescent cAMP and arrestin assays facilitate the identification of novel ‘biased agonists’. Detailed methods are provided for in vivo imaging of receptors using positron emission tomography (PET).

Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Receptor Binding Techniques, Third Edition, aids scientists in continuing to study receptor binding.

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Physics for Clinical Oncology (Radiotherapy in Practice) 2nd Edition

Physics for Clinical Oncology (Radiotherapy in Practice) 2nd Edition

Radiotherapy remains a major non-surgical treatment modality for malignant disease, and an understanding of how this treatment works is essential in ensuring optimum practice. Trainees in oncology learn about ionising radiation, but to understand it fully they must also understand the physics relevant to its use in therapy.

This book is written specifically for the oncology and radiation team, supporting clinical oncologists in their understanding of the science which underpins radiotherapy. It begins with basic concepts and then explores the principles and practice of physics as it relates to radiotherapy, including discussion of specific types of therapy.

Written by authors chosen for their expertise in in their respective fields, and aligned to the Royal College of Radiologists FRCR Curriculum in Oncology, this volume will provide an excellent source of information for trainee and practicing oncologists, and wider radiotherapy teams. This second edition has been fully updated to reflect advances in technology and the increased complexity in modern radiotherapy, including two new chapters on imaging and a new brachytherapy chapter.

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Principles and Practice of Pediatric Infectious Diseases 5th Edition

Principles and Practice of Pediatric Infectious Diseases 5th Edition

Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 5th Edition, by Drs. Sarah Long, Charles Prober, and Marc Fischer, is your go-to resource for authoritative information on infectious diseases in children and adolescents. A veritable “who’s who” of global authorities provides the practical knowledge you need to understand, diagnose, and manage almost any pediatric infectious disease you may encounter.

  • Features a consistent, easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables.
  • Allows quick look-up by clinical presentation, pathogen, or type of host.
  • Includes coverage of the latest vaccine products, recommendations, and effectiveness as well as expanded diagnostics and therapies for autoinflammatory/periodic fever syndromes.

  • Covers emerging viruses such as Zika, Ebola, and EV-D68, as well as infectious risks of immunomodulating drugs and expanding antimicrobial resistance patterns.

  • Discusses expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections.

  • Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

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Primer on the Autonomic Nervous System 4th Edition

Primer on the Autonomic Nervous System 4th Edition

Primer on the Autonomic Nervous System, Fourth Edition provides a concise and accessible overview of autonomic neuroscience for students, scientists, and clinicians. The book’s 142 chapters draw on the expertise of more than 215 basic scientists and clinicians who discuss key information on how the autonomic nervous system controls the body, particularly in response to stress. This new edition also focuses on the translational crossover between basic and clinical research. In addition to comprehensively covering all aspects of autonomic physiology and pathology, topics such as psychopharmacology decoding and modulating nerve function are also explored.

  • Provides concise and practical information on the autonomic nervous system
  • Discusses all aspects of autonomic physiology and pathology
  • Contains new content on psychopharmacology and modulating nerve function

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MR Neuroimaging: Brain, Spine, Peripheral Nerves 1st Edition

MR Neuroimaging: Brain, Spine, Peripheral Nerves 1st Edition

100% pure MR imaging of the CNS…comprehensive, up to date, essential

The imaging quality achievable in MR imaging today was inconceivable just a few years ago. No other subdiscipline has evolved so swiftly while placing ever-greater emphasis on fast and accurate results. This book is intended as an indispensable tool at the workplace, as reference for image interpretation, and even for fast orientation during the examination. Adjunct information is provided that fosters the dialogue with referring physicians: for most diseases and conditions there are summaries of epidemiology, clinical findings, pathogenesis and pathophysiology, as well as basic therapy concepts.

Special features:

  • A fast-reference guide, even in tricky cases-differential diagnosis made easy, with high clinical relevance
  • Tips for organizing examinations
  • Reference images for comparison with actual images
  • A reference book for looking up equivocal findings
  • More than 1,300 vivid, high-resolution images from the latest generation of scanners
  • Coverage of peripheral nervous system diseases and MR neurography
  • Answers to questions such as:
  • What technique is best for answering a specific question?

For all radiologists in hospital or office settings, also for neurologists and neurosurgeons.

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Farquharson’s Textbook of Operative General Surgery, 10th Edition 10th Edition

Farquharson’s Textbook of Operative General Surgery 10th Edition

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Sixty years after its first publication, Farquharson’s Textbook of Operative General Surgery remains firmly established as a classic textbook for general surgeons throughout the world, whether they are just embarking on training or are well established in their career. This tenth edition has been fully revised and updated, while retaining the core philosophy that has ensured its popularity over six decades―to provide an authoritative guide to operative surgery for the general surgeon in a manageable single volume.

Farquharson’s Textbook of Operative General Surgery covers not only basic techniques for the junior trainee but also the common operations in the general surgical subspecialties that are likely to be encountered during higher surgical training. In addition, the book describes procedures for the general surgeon in a remote hospital, who may have to operate outside his or her specialty and offer a limited service in orthopaedics, neurosurgery, urology or obstetrics.

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Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers 2nd Edition

Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers 2nd Edition

A unique question-and-answer book for surgical residents and trainees that covers all surgical aspects of critical care and acute or emergency medicine 

This is a comprehensive, one-of-a-kind question-and-answer text for medical professionals and apprentices concentrating on the growing subspecialty of surgery in critical care and emergency surgery. Covering all surgical aspects of critical care and acute or emergency surgery, it is an ideal learning and review text for surgical residents and trainees who care for these patients and those taking the Surgical Critical Care Board Examination.

Edited by highly experienced professionals, and written in an engaging style, Surgical Critical Care and Emergency Surgery: Clinical Questions and Answers focuses exclusively on the unique problems and complexity of illnesses of the critically ill and injured surgical patient, and covers the specialist daily care such patients require. It reflects the latest advances in medical knowledge and technology, and includes fully revised and updated questions throughout, with additional topics addressed in a new companion website. 

  • Unique question-and-answer book on the growing specialty of critical care and acute surgery
  • Ideal for US boards candidates
  • Covers trauma and burns as well as critical care
  • 8 page full-color insert showing high quality surgical photos to aid study
  • Supplementary website including additional questions

Surgical Critical Care and Emergency Surgery, Second Edition is an excellent resource for medical students, residents, fellows, and surgeons, as well as those in non-surgical specialties.

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Problem-Based Anatomy 1st Edition

Problem-Based Anatomy 1st Edition

This new text features a compilation of clinical cases that use a problem-based approach to illustrate the clinical significance of the subdisciplines of anatomy. Seven separate sections present anatomy in a regional format. Each section contains several clinical cases that walk you through various patients’ presentation, history and physical examination information, laboratory and diagnostic test results, diagnosis, and treatment. A series of related questions and accompanying answers follow each clinical scenario, probing your understanding of the clinical issues relevant to that body region.

  • Features more than 80 clinical scenarios that promote interactive learning and build a foundation of knowledge for clinical practice.
  • Presents information in seven sections to correspond with a regional approach to anatomy: head and neck, back, thorax, pelvis and perineum, upper extremity, and lower extremity.
  • Covers the subdisciplines of anatomy including anatomic pathology · cell biology · embryology · gross anatomy · histology · neuroanatomy · and radiologic anatomy.
  • Includes references to Gray’s Anatomy for Students, and follows a parallel organization, making it easy to use both books together.

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Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing 1st Edition

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing 1st Edition

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described.

The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests.

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions.

  • Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient
  • Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease
  • Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions
  • Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

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