Differential Diagnosis in Pediatric Dermatology 2013th Edition

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This book is devoted exclusively to differential diagnosis in pediatric dermatology. It covers the full range of relevant conditions: inherited skin disorders; nevi; viral, bacterial, fungal, and parasitic infections; acne; allergic diseases; autoimmune skin disorders; connective tissue diseases; tumors; and miscellaneous conditions. Each comparison addresses the differential diagnosis between two (or occasionally three or four) dermatological conditions, containing between two and six images and a short text emphasizing the clinical differences between the diseases in question. At the end of each chapter, a summary highlights one or two characteristics essential for the differential diagnosis. The author is an expert who, since 1982, has been responsible for a column devoted to the differential diagnosis of pediatric dermatology in the European Journal of Pediatric Dermatology. The volume will represent an ideal tool for pediatric dermatologists, pediatricians, and GPs, and will help them in the diagnostic process.​

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Metal Complex – DNA Interactions 1st Edition

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Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.

Metal Complex – DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:

  • Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models.
  • Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.
  • DNA-Recognition – Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.
  • Toxicological Aspects: deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.

This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.

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Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine 1st Edition

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There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species.

In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on ‘Metallotherapeutics’ throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered:

  • non-invasive radiopharmaceuticals
  • Magnetic Resonance Imaging (MRI)
  • mineral supplements

From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.

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Method Validation in Pharmaceutical Analysis: A Guide to Best Practice 2nd Edition

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This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing.

As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout.

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Nuclear Hepatology: A Textbook of Hepatobiliary Diseases

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Since the publication of the first edition of Nuclear Hepatology almost 10 years ago, new advances have taken place, both in our understanding of liver pathophysiology and various imaging modalities. A unique feature of imaging of physiology is that it enables quanti- cation. Since liver physiology is complex, quantification has been a challenge. Many p- lications in the past have often included quantification based on home-made software not available for others. Thus, the comparison of results from one center to another becomes difficult, if not impossible. The second edition of Nuclear Hepatology addresses these issues. Sophisticated software for liver and gallbladder function has been tested and va- dated through many of our previous publications. Now that software is FDA approved and available for others through a commercial company, it is hoped that future publications of imaging of liver and gallbladder physiology would routinely include quantification. Although the function of the hepatocyte is complex, it can be broadly divided into two main categories, substrate uptake at the basolateral border and intracellular transit prior to excretion into the canaliculi. The earliest manifestation of hepatocellular injury occurs in the form of prolongation of the intracellular transit time, which occurs long before the disruption of the basolateral border with subsequent rupture and death. The liver enzymes are released into circulation after the death of the hepatocyte.

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Viral Infections and Treatment (Infectious Disease & Therapy)

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Examining the pathology and transmission of the most common viral diseases, this reference compiles reviews by international specialists which detail breakthroughs in patient management, diagnostics and treatment of viral infections. The text also describes specific therapeutic agents according to their mode of action and clinical applications, as well as practical treatment recommendations and guidelines for improved patient care.

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Innovations in the Treatment of Substance Addiction

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Emerging approaches to treating addictions and minimizing relapse are spotlighted in this idea-packed volume, as alternatives or adjuncts to standard psychological and pharmacological therapies. Its biopsychosocial perspective delves into the causes and processes of chemical dependence, and the clinical characteristics it shares with other addictions (e.g., food, sex, gambling, online activities), to identify client needs that substance abuse may fulfill. Accordingly, the diverse modalities featured here address substance addiction on multiple levels, offering clients physical or mental stimulation and/or emotional relief as well as affording different degrees of autonomy. Methods can be mixed and matched to reinforce treatment goals, and clinicians can tailor treatment to individual issues and interests to assure clients nuanced and meaningful care.

 

Included in the coverage:

 

·         Use of herbal medicine to treat drug addiction.

·         EMDR therapy and the treatment of substance abuse and addiction.

·         Evaluating the change processes in drug users’ interventions.

·         Web-based interventions for substance abuse.

·         Physical exercise and treatment of addiction.

·         Mindfulness to reduce the anxiety during the abstinence

·         Neurofeedback to deal with craving and anxiety symptoms

Psychologists, psychiatrists, clinical social workers, and addiction counselors and educators will find Innovations in the Treatment of Substance Addiction a valuable sourcebook for understanding addiction―and intervention―in its wider context.

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Cognitive Neuroscience: A Very Short Introduction (Very Short Introductions)

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Up to the 1960s, psychology was deeply under the influence of behaviourism, which focused on stimuli and responses, and regarded consideration of what may happen in the mind as unapproachable scientifically. This began to change with the devising of methods to try to tap into what was going on in the ‘black box’ of the mind, and the development of ‘cognitive psychology’. With the study of patients who had suffered brain damage or injury to limited parts of the brain, outlines of brain components and processes began to take shape, and by the end of the 1970s, a new science, cognitive neuroscience, was born. But it was with the development of ways of accessing activation of the working brain using imaging techniques such as PET and fMRI that cognitive neuroscience came into its own, as a science cutting across psychology and neuroscience, with strong connections to philosophy of mind. Experiments involving subjects in scanners while doing various tasks, thinking, problem solving, and remembering are shedding light on the brain processes involved. The research is exciting and new, and often makes media headlines. But there is much misunderstanding about what brain imaging tells us, and the interpretation of studies on cognition.

In this Very Short Introduction Richard Passingham, a distinguished cognitive neuroscientist, gives a provocative and exciting account of the nature and scope of this relatively new field, and the techniques available to us, focusing on investigation of the human brain. He explains what brain imaging shows, pointing out common misconceptions, and gives a brief overview of the different aspects of human cognition: perceiving, attending, remembering, reasoning, deciding, and acting. Passingham concludes with a discussion of the exciting advances that may lie ahead.

ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

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The 15 Minute Heart Cure: The Natural Way to Release Stress and Heal Your Heart in Just Minutes a Day

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From a top cardiologist–simple stress–reduction techniques to prevent and reverse the four major kinds of heart disease The 15 Minute Heart Cure shows how stress can harm our cardiovascular system and offers practical, easy ways to dispel stress naturally, without spending a lot of time or money. It explains the stress–heart disease connection for the four major types of heart disease–heart attack, arrythmia, congestive heart failure, and cardiac valve disease–and equips you with the author′s proven BREATHE technique to help you stop stress in its tracks. Teaches the BREATHE (beginning, relaxation, envision, apply, treatment, heal, end) technique to help you heal and protect your heart Gives you specific stress–reducing breathing and guided imagery exercises you can do anywhere, anytime First book by a leading cardiologist on the stress–heart disease connection–Dr. Kennedy is the former director of Cardiac Catheterization Laboratory and director of Inpatient Cardiology, Kaiser Permanente Medical Center, San Rafael, CA and the current medical director of Preventive Cardiology and Wellness, Marina Del Rey Hospital, Marina Del Rey, California, and member of the Board of the American Heart Association Includes real–life case examples from the author′s extensive clinical experience. Don′t let stress hurt your heart. Unleash the healing benefits of The 15 Minute Heart Cure and discover the wonderful sense of focus and calm it will bring to your life.

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