Anticancer Therapeutics: From Drug Discovery to Clinical Applications 1st Edition

Anticancer Therapeutics: From Drug Discovery to Clinical Applications 1st Edition

An integrated presentation of the basic science and clinical applications of anticancer agents

Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications.

After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year.

Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers.

  • Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics
  • Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology
  • Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect
  • Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers.

Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

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Understanding Epilepsy: A Study Guide for the Boards 1st Edition

Understanding Epilepsy: A Study Guide for the Boards 1st Edition

Written by experts in the field, this book offers an up-to-date and systematic approach to understanding epilepsy. It focuses on advanced tools and therapies in diagnosis and management, and comprehensively yet simply covers the content of the American Board of Psychiatry and Neurology certification. Five sections comprise the main text: mechanisms, classification, EEG technical concepts, diagnostic tools, and management. Pathophysiology and pathology of epilepsies are covered, as well as classification of seizures and epilepsies, electro-clinical syndromes, non-epileptic spells, and status epilepticus. Contributors also discuss diagnostic tools such as scalp and intracranial EEG, neuroimaging, and neuropsychological tests, in addition to the management of epilepsy and associated concerns, including anti-seizure drugs, surgical and stimulation therapies, gender issues, comorbidities, and psychosocial aspects. Tables, high-quality pathology, radiology and clinical images, and EEG illustrations aid readers in understanding content. A valuable book for medical trainees, neurologists, neurosurgeons, nurses and EEG technologists, and essential certification preparation.

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Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease 1st Edition

Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease 1st Edition

While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies – bariatric surgery, liposuction, physical and dietary intervention – of which information is desired among health specialists and policy makers.

  • Brings together up-to-date research on imaging, genetics, and risk factors for chronic diseases such as diabetes, heart disease, cancer, and fatty liver disease
  • Takes a deep dive into the current state of knowledge regarding fat stores, ectopic fat, regulation of fat stores, clinical implications, interventions, and imagining techniques
  • Provides up-to-date information specifically focused on visceral and ectopic fat. In addition, both pathophysiological and preventive and treatment aspects of the problem will be considered
  • Covers a broad range of organs – different fat stores such as skeletal muscle, bone marrow, liver and kidney
  • Discusses potential interventions to reduce abdominal fat

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Transfusion Medicine 5th Edition

Transfusion Medicine 5th Edition

Explore this concise and clinically focused approach to the field of blood banking and transfusion therapy  

The Fifth Edition of Transfusion Medicine delivers a succinct, thorough, clinically focused, practical and authoritative treatment of a full range of topics in transfusion therapy. This ranges from issues with the blood supply, recruitment of both whole blood and apheresis donors, blood collection and storage, blood testing, blood safety, and transmissible diseases. This edition has been fully updated and revised to include exciting cellular therapies for cancer, transplantation of both hematopoietic cells and solid organs, infectious diseases and regenerative medicine.       

The Fifth Edition includes new authors with highly relevant content that provides a solid grounding for readers in the field. The book:  

  • Is an approachable comprehensive guide to the field of blood banking and transfusion medicine 
  • Provides complete and timely perspective on  crucial topics, including the HLA system in transfusion medicine and transplantation and quality programs in blood banking and transfusion medicine 
  • Is extensively referenced, making it simple for readers to conduct further research on the topics of interest to them  
  • Includes new chapters on pediatric transfusion medicine and pathogen reduction  
  • Has an expended chapter on patient blood management 
  • Provides extensive discussions of the clinical use of blood transfusion in a wide variety of clinical situations including recent development In the management of acute traumatic blood loss   
  • Provides updated information about blood groups and molecular testing making inroads into clinical practice along with discussions of laboratory detection of blood groups and provision of red cells  

Perfect for all those working in the field of blood banking, transfusion medicine and hematology or oncology and fellows in pathology, hematology, surgery and anesthesiology. Transfusion Medicine is a good introduction for technologists specializing in blood banking and non-medical personnel working in areas related to hematology and transfusion medicine. Transfusion Medicine will also earn a place in the libraries of practicing pathologists with responsibility for  blood banks. 

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Treatment of Skin Disease: Comprehensive Therapeutic Strategies 6th Edition

Treatment of Skin Disease: Comprehensive Therapeutic Strategies 6th Edition

Covering nearly 260 of the most common dermatologic conditions from A to Z, Treatment of Skin Disease, 6th Edition, by Drs. Mark G. Lebwohl, Warren R. Heymann, Ian Coulson, and Dedee Murrell, is your go-to resource for authoritative, evidence-based treatment strategies in your daily practice. This award-winning text provides guidance on the fast-moving dermatological therapy options for virtually any skin disease you’re likely to encounter, including third-line and unusual therapies when initial options have not been successful. Summaries of each treatment strategy are accompanied by detailed discussions of treatment choices, with ratings on a consistent scale ranging from clinical studies to anecdotal reports.

  • Puts every possible therapeutic option at your disposal – including management strategies, first- to third-line therapies, and off-label uses – for a truly complete guide to the vast array of dermatologic treatment options. 
  • Features 4 all-new chapters on COVID-19 dermatoses, including the associated pediatric multisystem inflammatory syndrome; DRESS syndrome; keratosis lichenoides chronica; and tinea corporis and tinea cruris. 
  • Presents information in a consistent, tabular format, with checklists of diagnostic and investigative pearls and color-coded boxes for quick reference. 
  • Provides more than 260 full-color clinical images of skin diseases, most of which are new to this edition. 
  • Offers the combined knowledge and expertise of the world’s leading authorities in dermatology. 
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

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The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children 2nd Edition

The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children 2nd Edition

The identification of the cause of an epileptic seizure is a key element in the clinical management of all patients. In recent decades, advances in theory, neuroimaging, molecular genetics and molecular chemistry have revolutionized our ability to investigate and identify the underlying cause. The definitive and unrivalled textbook on the causes of epilepsy, this second edition is extensively revised and expanded. It provides concise descriptions of all the major genetic and acquired conditions that cause epilepsy in adults and children, and the provoking factors for epileptic seizures and of the causes of status epilepticus. A new section consider clinical approaches to diagnosing causes, to guide and assist clinicians in investigations. With 128 chapters written by leading figures from around the world, this comprehensive and authoritative resource is indispensable to senior and junior clinicians and trainees working in the field of epilepsy, including specialists in neurology, paediatrics, neurophysiology, psychiatry and neurosurgery.

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The Liver: Biology and Pathobiology 6th Edition

The Liver: Biology and Pathobiology 6th Edition

Bridging the gap between basic scientific advances and the understanding of liver disease ― the extensively revised new edition of the premier text in the field.

The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more.

Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters ― including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology ― provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume:

  • Relates molecular physiology to understanding disease pathology and treatment
  • Links the science and pathology of the liver to practical clinical applications
  • Features 16 new “Horizons” chapters that explore new and emerging science and technology
  • Includes plentiful full-color illustrations and figures

The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

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Step-Up to Medicine (Step-Up Series) 5th Edition

Step-Up to Medicine (Step-Up Series) 5th Edition

Find what you need to know—fast This bestselling volume in the popular Step-Up series provides a high-yield review of medicine, ideal for preparing for clerkships or clinical rotations, shelf exams, and the USMLE Step 2. Clinical pearls, full-color illustrations, and “Quick Hits” provide essential information in an efficient, easy-to-remember manner to help you excel on your exams and succeed in the clinical setting. Also includes a 100-question practice exam to support preparation. 

  • Updated and revised content reflects extensive research with faculty and students.
  • Figures, charts, tables, graphs, and mnemonics aid visual learners and facilitate retention of essential material.
  • Enhanced high-yield outline format and Quick Hits save time and help students review more efficiently.
  • 100-question practice exam helps students prepare for shelf and board.
  • Succinct, outline approach keeps “extra” material to a minimum, focusing on the core content students need to know.
  • Clinical pearls help students “file away” clinical connections for handy retrieval at test time and aid in the transition from basic science to clinical medicine.
  • Easy-to-follow algorithms demonstrate examples of effective clinical reasoning, particularly for similar complaints.
  • Coverage includes every essential area of medicine, including body system diseases and disorders; fluids, electrolytes, and acid-base disorders; hematologic diseases and neoplasms; infectious diseases; diseases of the skin and hypersensitivity disorders; and ambulatory medicine.
  • Helpful appendices cover radiographic and electrocardiogram interpretation, physical examination pearls, workup and management of common problems on the wards, basic statistics and evidence-based medicine, and end-of-life issues and informed consent.

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Probiotics for Human Nutrition in Health and Disease

Probiotics for Human Nutrition in Health and Disease 

Probiotics for Human Nutrition in Health and Disease provides a comprehensive resource of information on traditional and emerging health concepts and the development and application evolution of probiotics and their role in prevention and treatment of human metabolic disorders and illnesses. Key issues related to the general aspects of probiotics, probiotics in human nutrition, and probiotics in human health promotion and disease treatment are described and discussed. Sections discuss general features of probiotics, such as relationships with prebiotics, probiotics in human nutrition, including pregnancy, lactation, in children, and in the elderly, and the role of probiotics in human health and disease treatment.

This book provides the most significant knowledge, mechanistic bases, uses, clinical perceptions, case studies and perspectives about probiotics for humans, considering possibilities and limitations in light of the appropriate available reference materials. Written by highly qualified researchers and edited by a team of experts, each chapter summarizes the latest available information on probiotics in human health and critically interprets the most significant evidence by applying the author’s own practical experience from investigations with probiotics.

  • Present traditional and emerging concepts, developments and the evolution of probiotics
  • Provides key insights that characterize probiotics as promising and innovative options for human nutrition
  • Discusses how probiotics can be used in a perspective of health promotion and prevention and treatment of human metabolic disorders and illnesses

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Principles and Practice of Sleep Medicine – 2 Volume Set 7th Edition

Principles and Practice of Sleep Medicine – 2 Volume Set 7th Edition

Offering today’s most authoritative, comprehensive coverage of sleep disorders, Kryger’s Principles and Practice of Sleep Medicine, 7th Edition, is a must-have resource for sleep medicine specialists, fellows, trainees, and technicians, as well as pulmonologists, neurologists, and other clinicians who see patients with sleep-related issues. It provides a solid understanding of underlying basic science as well as complete coverage of emerging advances in management and treatment for a widely diverse patient population. Evidence-based content, hundreds of full-color illustrations, and a wealth of additional resources online help you make well-informed clinical decisions and offer your patients the best possible care.

  • Contains new chapters on sleep in intersex and transgender individuals; sleep telemedicine and remote PAP adherence monitoring; and sleep and the menstrual cycle, as well as increased coverage of treatment and management of pediatric patients. 
  • Includes expanded sections on pharmacology, sleep in individuals with other medical disorders, and methodology. 
  • Discusses updated treatments for sleep apnea and advancements in CPAP therapy. 
  • Offers access to 95 video clips online, including expert interviews and sleep study footage of various sleep disorders. 
  • Meets the needs of practicing clinicians as well as those preparing for the sleep medicine fellowship examination or recertification exams, with more than 950 self-assessment questions, answers, and rationales online. 
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

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